Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword

Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217451 - 217451

Published: Jan. 8, 2025

Language: Английский

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Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 31, 2024

Abstract Cancer neuroscience is an emerging field that investigates the intricate relationship between nervous system and cancer, gaining increasing recognition for its importance. The central governs development of directly affects brain tumors, peripheral (PNS) shapes tumor microenvironment (TME) tumors. Both systems are crucial in cancer initiation progression, with recent studies revealing a more role PNS within TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating bidirectional interaction cancers. Notably, immune cells contribute this communication, forming triangular influences protumor inflammation effectiveness immunotherapy. This review delves into mechanisms connecting focusing on how various cell types influence nerve‒tumor interactions, emphasizing clinical relevance nerve‒immune dynamics. By deepening our understanding interplay nerves, cells, has potential reshape biology insights, inspire innovative therapies, improve outcomes patients.

Language: Английский

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A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 884 - 901

Published: Oct. 1, 2024

Language: Английский

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Perceived association of mood and symptom severity in adults with mitochondrial diseases

Mitochondrion, Journal Year: 2025, Volume and Issue: unknown, P. 102033 - 102033

Published: March 1, 2025

Language: Английский

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Effect of glucocorticoid blockade on inflammatory responses to acute sleep fragmentation in male mice

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17539 - e17539

Published: June 28, 2024

The association between sleep and the immune-endocrine system is well recognized, but nature of that relationship not understood. Sleep fragmentation induces a pro-inflammatory response in peripheral tissues brain, it also activates hypothalamic-pituitary-adrenal (HPA) axis, releasing glucocorticoids (GCs) (cortisol humans corticosterone mice). It unclear whether this rapid release acts to potentiate or dampen inflammatory short term. purpose study was determine blocking suppressing glucocorticoid activity will affect from acute (ASF). Male C57BL/6J mice were injected i.p. with either 0.9% NaCl (vehicle 1), metyrapone (a synthesis inhibitor, dissolved vehicle 2% ethanol polyethylene glycol 2), mifepristone receptor antagonist, 2) 10 min before start ASF no (NSF). After 24 h, samples collected brain (prefrontal cortex, hypothalamus, hippocampus) periphery (liver, spleen, heart, epididymal white adipose tissue (EWAT)). Proinflammatory gene expression (TNF- α IL-1 β ) measured, followed by analysis. Metyrapone treatment affected cytokine during some tissues, brain. More specifically, suppressed EWAT ASF, which implies effect GCs. However, cardiac tissue, increased TNF- mice, suggesting an anti-inflammatory Mifepristone yielded more significant results than metyrapone, reducing liver (only NSF mice) indicating role. Conversely, spleen ASF-mice, cytokines ), demonstrating Furthermore, irrespective fragmentation, heart (IL-1 pre-frontal cortex hypothalamus ). provide mixed evidence for pro- functions regulate responses loss.

Language: Английский

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Stress increases sperm respiration and motility in mice and men

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 11, 2024

Language: Английский

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Perceived association of mood and symptom severity in adults with mitochondrial diseases

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Abstract Individuals with genetic mitochondrial diseases suffer from multisystemic symptoms that vary in severity day-to-day and week-to-week, but the underlying causes of symptomatic fluctuations are not understood. Based upon observations that: i) patients their families frequently report stressful life events either trigger exacerbations existing or onset new symptoms, ii) psychological states stress hormones influence energy production capacity, iii) epidemiological reports document a robust connection between traumatic/stressful various neurologic disorders, we hypothesized disease symptom may according to participant’s mood. To investigate this administered Stress, Health Emotion Survey (SHES) 70 adults (majority white (84%) cisgender women (83%), ages 18-74) self-reported (MELAS, 18%; CPEO, 17%; Complex I deficiency, 13%). Participants rated each symptom(s) over past year on good bad days. On days marked by more stress, sadness other negative emotions, some all were reported be worse, including fatigue, exercise intolerance, brain fog, fine motor coordination. By contrast, happiness calmness, participants these better, less severe. Other diminished sweating, hearing problems, dystonia general unrelated Thus, individuals living diseases, at times perceive mood severity. These preliminary associative results constitute an initial step towards developing comprehensive models factors clinical course diseases.

Language: Английский

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Profiling mRNA encoding glucocorticoid receptor α in saliva: Relationship to hair cortisol levels in individuals aged 15-25 years

Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 171, P. 106158 - 106158

Published: Dec. 4, 2024

Language: Английский

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