Marine natural products

Natural Product Reports, Journal Year: 2019, Volume and Issue: 36(1), P. 122 - 173

Published: Jan. 1, 2019

A comprehensive review of 1490 new MNPs including the first naturally occurring blue zwitterionic quinoids dactylocyanines A–H is presented.

Language: Английский

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Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

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Evolution of neuropeptide signalling systems

Journal of Experimental Biology, Journal Year: 2018, Volume and Issue: 221(3)

Published: Feb. 1, 2018

ABSTRACT Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships evolutionary origins heterogeneous assemblage neuropeptides identified range phyla has presented huge challenge for comparative physiologists. Here, we review revolutionary insights into evolution neuropeptide have been obtained recently through analysis genome/transcriptome sequence data by ‘deorphanisation’ receptors. The at least 30 systems traced to common ancestor protostomes deuterostomes. Furthermore, two rounds genome duplication gave rise an expanded repertoire vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss additional or duplications generating complex patterns phylogenetic distribution paralogous systems. We entering new era research where it become feasible compare roles orthologous wide phyla. Moreover, ambitious mission reconstruct function animal kingdom now represents tangible future.

Language: Английский

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Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates

Frontiers in Endocrinology, Journal Year: 2019, Volume and Issue: 10

Published: Feb. 19, 2019

Numerous neuropeptide systems have been implicated to coordinately control energy homeostasis, both centrally and peripherally. However, the vertebrate Y (NPY) system has emerged as best described one regarding this biological process. The protostomian ortholog of NPY is F, characterized by an RXRF(Y)amide carboxyterminal motif. A second short NPF, M/T/L/FRF(W)amide Although long NPF display sequence similarities, they are evolutionary distant likely already arose separate signalling in common ancestor deuterostomes protostomes, indicating functional importance both. Both short-NPF seem roles coordination feeding across bilaterian species, but during chordate evolution, appears lost or evolved into prolactin releasing peptide system, which regulates suggested be orthologous sNPF. Here we review sNPF regulation metabolism invertebrates.

Language: Английский

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Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Nov. 20, 2019

Tachykinins (TKs) are ancient neuropeptides present throughout the bilaterians and are, with some exceptions, characterized by a conserved FX1GX2Ramide carboxy terminus among protostomes FXGLMamide in deuterostomes. The best-known TK is vertebrate substance P, which mammals, together other TKs, has been implicated health disease important roles pain, inflammation, cancer, depressive disorder, immune system, gut function, hematopoiesis, sensory processing, hormone regulation. invertebrate TKs also known to have multiple functions central nervous system intestine these investigated more detail fly Drosophila arthropods. Here, we review protostome deuterostome organization evolution of precursors, peptides their receptors, as well functions, appear be partly across Bilateria. We outline distribution brains representative organisms. In Drosophila, recent studies revealed early olfactory neuromodulation circuits controlling locomotion food search, nociception, aggression, metabolic stress, release. signaling regulates lipid metabolism intestine. crustaceans, an neuromodulator rhythm-generating motor stomatogastric presynaptic modulator photoreceptor cells. Several additional functional can inferred from various brain circuits. addition, there few interesting cases where injected into prey animals vasodilators salivary glands or paralyzing agents venom glands. cases, produced predator sequences mimicking TKs. Lastly, TK-signaling appears duplicated Panarthropoda (comprising arthropods, onychophores, tardigrades) give rise novel type peptides, natalisins, distinct receptor. natalisins general, it that widely distributed act at short range neuromodulators cotransmitters.

Language: Английский

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Premetazoan Origin of Neuropeptide Signaling

Molecular Biology and Evolution, Journal Year: 2022, Volume and Issue: 39(4)

Published: March 7, 2022

Abstract Neuropeptides are a diverse class of signaling molecules in metazoans. They occur all animals with nervous system and also neuron-less placozoans. However, their origin has remained unclear because no neuropeptide shows deep homology across lineages, none have been found sponges. Here, we identify two precursors, phoenixin (PNX) nesfatin, broad evolutionary conservation. By database searches, sequence alignments, gene-structure comparisons, show that both precursors present bilaterians, cnidarians, ctenophores, We PNX secreted nesfatin precursor homolog the choanoflagellate Salpingoeca rosetta. PNX, particular, is highly conserved, including its cleavage sites, suggesting prohormone processing occurs choanoflagellates. In addition, based on phyletic patterns negative pharmacological assays, question originally proposed GPR-173 (SREB3) as receptor. Our findings revealed homologs derived from longer premetazoan origins thus evolved before neurons.

Language: Английский

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Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 584, P. 112162 - 112162

Published: Jan. 28, 2024

Peptides and protein hormones form the largest group of secreted signals that mediate intercellular communication are central regulators physiology behavior in all animals. Phylogenetic analyses biochemical identifications peptide-receptor systems reveal a broad evolutionary conservation these signaling at molecular level. Substantial progress has been made recent years on characterizing physiological putative ancestral roles many peptide through comparative studies invertebrate models. Several peptides not only molecularly conserved but also have across animal phyla. Here, we focus functional insights gained nematode Caenorhabditis elegans that, with its compact well-described nervous system, provides powerful model to dissect neuroendocrine networks involved control behavior. We summarize discoveries knowledge functions hormone C. elegans.

Language: Английский

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Transcriptomic discovery and comparative analysis of neuropeptide precursors in sea cucumbers (Holothuroidea)

Peptides, Journal Year: 2017, Volume and Issue: 99, P. 231 - 240

Published: Oct. 18, 2017

Language: Английский

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A G protein–coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia

PLoS Biology, Journal Year: 2020, Volume and Issue: 18(3), P. e3000614 - e3000614

Published: March 3, 2020

The reproductive hormones that trigger oocyte meiotic maturation and release from the ovary vary greatly between animal species. Identification of receptors for these maturation-inducing (MIHs) understanding how they initiate largely conserved process remain important challenges. In hydrozoan cnidarians including jellyfish Clytia hemisphaerica, MIH comprises neuropeptides released somatic cells gonad. We identified receptor (MIHR) in using cell culture–based "deorphanization" candidate oocyte-expressed G protein–coupled (GPCRs). MIHR mutant generated CRISPR-Cas9 editing had severe defects gamete development or spawning both males females. Female gonads, oocytes isolated mutants, failed to respond synthetic MIH. Treatment with cAMP analogue Br-cAMP mimic rise at onset rescued spawning. Injection inhibitory antibodies alpha subunit Gs heterodimeric protein (GαS) into wild-type phenocopied mutants. These results provide molecular links stimulation initiation oocytes. Molecular phylogeny grouped a subset bilaterian neuropeptide receptors, Y, gonadotropin hormone (GnIH), pyroglutamylated RFamide, luqin, all upstream regulators sexual reproduction. This identification functional characterization cnidarian peptide GPCR advances our sheds light on evolution neuropeptide-hormone systems.

Language: Английский

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Ancient origins of arthropod moulting pathway components

eLife, Journal Year: 2019, Volume and Issue: 8

Published: July 3, 2019

Ecdysis (moulting) is the defining character of Ecdysoza (arthropods, nematodes and related phyla). Despite superficial similarities, signalling cascade underlying moulting differs between Panarthropoda remaining ecdysozoans. Here, we reconstruct evolution major components ecdysis pathway. Its key elements evolved much earlier than previously thought are present in non-moulting lophotrochozoans deuterostomes. Eclosion hormone (EH) bursicon originated prior to cnidarian-bilaterian split, whereas ecdysis-triggering (ETH) crustacean cardioactive peptide (CCAP) bilaterian last common ancestor (LCA). Identification EH, CCAP Onychophora ETH Tardigrada suggests that pathway was panarthropod LCA. Trunk, an ancient extracellular molecule a well-established paralog insect prothoracicotropic (PTTH), non-bilaterian ctenophore Mnemiopsis leidyi. This constitutes first case with homology neuropeptide.

Language: Английский

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