Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(10), P. 679 - 689

Published: May 17, 2021

Language: Английский

---

The evolutionary ecology of circadian rhythms in infection

Nature Ecology & Evolution, Journal Year: 2019, Volume and Issue: 3(4), P. 552 - 560

Published: March 18, 2019

Language: Английский

---

Timing avian long-distance migration: from internal clock mechanisms to global flights

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2017, Volume and Issue: 372(1734), P. 20160252 - 20160252

Published: Oct. 9, 2017

Migratory birds regularly perform impressive long-distance flights, which are timed relative to the anticipated environmental resources at destination areas that can be several thousand kilometres away. Timely migration requires diverse strategies and adaptations involve an intricate interplay between internal clock mechanisms conditions across annual cycle. Here we review what challenges face during long migrations keep track of time as they exploit geographically distant may vary in availability predictability, summarize enable them succeed. We examine following challenges: departing for spring autumn migration, anticipation future conditions; using clocks on move, example orientation, navigation stopover; adhering to, or adjusting, programme while fitting their activities into cycle; keeping pace with a world rapidly changing environments. then elaborate these themes by case studies representing migrating different movement patterns associated circannual programmes. discuss current knowledge how endogenous programmes interact external information cycle, components cycle encode topography range expansions, fitness affected when mismatches timing occur. Lastly, outline open questions propose research directions. This article is part themed issue ‘Wild clocks: integrating chronobiology ecology understand timekeeping free-living animals’.

Language: Английский

---

Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets

Trends in Immunology, Journal Year: 2019, Volume and Issue: 40(6), P. 524 - 537

Published: May 17, 2019

Leukocytes infiltrate tissues in a time-of-day-dependent manner, depending on subset- and tissue-specific rhythms promigratory factors. Murine neutrophils rhythmically many organs thereby change the phenotype of respective tissue. Adaptive immune responses, which take weeks to develop, are under circadian control mice, strongly depend time day when an initial stimulus is given. can cell-autonomously regulate their oscillations murine host by responding reactive oxygen species altering binding HIF-1α clock protein BMAL1, thus governing chemokine CXCR4 expression. Glucocorticoids transcriptionally expression IL-7 receptor manner driving rhythmic CD4+ CD8+ T cell redistribution across body. The number leukocytes circulating blood mammals (i.e., ∼24 h). We summarize here latest findings mechanisms leukocyte migration from into various organs, focusing distinct subtype- molecules involved. highlight oscillatory patterns adhesion molecules, chemokines, receptors that expressed endothelial cells leukocytes, crucial regulators recruitment. also discuss relevance genes for function migration. Finally, we compare steady-state conditions as well during inflammation disease, postulate how these provide potential new avenues therapeutic intervention. Organisms exposed recurring environmental daily light–dark cycle have adapted changes with finely tuned internal mechanism. This mechanism entrains (see Glossary) cues such light anticipate food availability threats [1Helm B. et al.Two sides coin: ecological chronobiological perspectives timing wild.Philos. Trans. R. Soc. Lond. B Biol. Sci. 2017; 37220160246Crossref PubMed Scopus (76) Google Scholar]. With respect mammalian system, most obvious oscillation found changing numbers blood. Preserved species, including humans [2Born J. al.Effects sleep rhythm human cells.J. Immunol. 1997; 158: 4454-4464PubMed Scholar], mice [3He W. al.Circadian migratory factors establishes lineage-specific signatures guide homing subsets tissues.Immunity. 2018; 49: 1175-1190Abstract Full Text PDF (104) rats [4Pelegri C. surface rat lymphocytes.Am. Physiol. Cell 2003; 284: C67-76Crossref (40) hamsters [5Prendergast B.J. al.Impaired trafficking skin inflammatory responses lacking functional system.Brain Behav. Immun. 2013; 32: 94-104Crossref (32) counts all display peak behavioral rest phase. becomes apparent owing phase delay between egress hematopoietic bone marrow (BM) subsequent immigration peripheral organs. Egress primarily occurs at onset phase, increases [6Lucas D. al.Mobilized stem yield depends species-specific timing.Cell Stem Cell. 2008; 3: 364-366Abstract (179) Scholar, 7Mendez-Ferrer S. al.Haematopoietic release regulated oscillations.Nature. 452: 442-447Crossref (945) whereas predominantly active turn leads decreased relative 8Scheiermann al.Adrenergic nerves govern recruitment 2012; 37: 290-301Abstract (335) In mammals, lighting captured eye then converted physiology region within anterior hypothalamus situated immediately above optic chiasm, called suprachiasmatic nucleus (SCN). SCN master organism. It intrinsically structure h period – even explanted cultured vitro [9Yamazaki al.Resetting central oscillators transgenic rats.Science. 2000; 288: 682-685Crossref (1488) Scholar] tight intercellular coupling among its neurons [10Brown T.M. Piggins H.D. Electrophysiology clock.Prog. Neurobiol. 2007; 82: 229-255Crossref (118) synchronizes autonomously oscillating clocks periphery relying humoral neural signals via hypothalamic–pituitary–adrenal (HPA) axis, potentially adrenergic sympathetic nervous system (SNS) [11Scheiermann system.Nat. Rev. 13: 190-198Crossref (611) These lack therefore need synchronization match organismal molecular cell-intrinsic present both innate adaptive [12Arjona A. Sarkar D.K. Circadian genes, cytolytic factors, cytokines NK 2005; 174: 7618-7624Crossref (170) 13Baumann al.The eosinophils mast cells.Immunology. 140: 465-474Crossref (56) 14Ella K. regulation neutrophils.Brain 2016; 57: 209-221Crossref (71) 15Keller M. al.A macrophages controls responses.Proc. Natl. Acad. U. 2009; 106: 21407-21412Crossref (560) 16Nguyen K.D. gene Bmal1 regulates diurnal Ly6Chi monocytes.Science. 341: 1483-1488Crossref (416) 17Silver A.C. mouse macrophages, dendritic cells, cells.Brain 26: 407-413Crossref (114) 18Wang X. marrow-derived modulates IgE-dependent activation vitro.Brain 2011; 25: 127-134Crossref consists multiple interlocking loops transcription BMAL1 [brain muscle aryl hydrocarbon nuclear translocator (ARNT)-like 1, encoded ARNTL], CLOCK (circadian locomotor output cycles kaput), PER1/2/3 (period homologs), REV-ERB α/β (encoded NR1D1/2) CRY1/2 (cryptochromes 1/2) [19Scheiermann al.Clocking immunity.Nat. 18: 423-437Crossref (249) 20Curtis A.M. proteins immunity.Immunity. 2014; 40: 178-186Abstract (367) Although studies used floxed models (Arntlflox) ablate machinery, it important note (in mice) paralog BMAL2, making difficult attribute observed effects specifically BMAL1. use radicals, produced cyclical additional means [21Zhao Y. al.Uncovering mystery opposite humanized mice.Blood. 130: 1995-2005Crossref (46) Mechanistically, this dependent mitogen-activated kinase (MAPK) hypoxia-inducible factor 1α (HIF-1α) ultimately regulating appears be more fundamental than transcription–translation feedback loop because radicals entrain devoid nuclei red cells) [22O'Neill J.S. Reddy A.B. cells.Nature. 469: 498-503Crossref (591) physiological day-to-day immature progenitor (HSPCs) [7Mendez-Ferrer mature BM, blood, was demonstrated complete BMAL1-deficient (Arntl−/−) [8Scheiermann Deletion core resulted abolition time-of-day HSPCs A similar after surgical denervation or absence β2- β3-adrenoreceptors scenarios diminished homing, highlighting importance local innervation However, whether SNS generally involved underlying entrainment [23Buijs R.M. al.Anatomical demonstration multisynaptic adrenal (cortex) pathway.Eur. Neurosci. 1999; 11: 1535-1544Crossref (394) 24Terazono H. liver.Proc. 100: 6795-6800Crossref (235) debated given rhythmicity retained deficient dopamine β-hydroxylase (Dbh−/−), signaling [25Reilly D.F. al.Peripheral signaling.Arterioscler. Thromb. Vasc. 28: 121-126Crossref (45) addition, GDNF family α2 (GFRα2) functions development/survival cholinergic neurons, recent observations GFRα2-deficient (Gfra2−/−) further implicated parasympathetic (PNS) migration, counterbalancing [26Garcia-Garcia al.Dual leukocytes.Blood. 2019; 133: 224-236Crossref (54) On one hand, morning acutely activates induce mobilization BM but, other reduce facilitating By contrast, night, dampen noradrenergic tone decrease leukocytes. Owing increased plasma adrenaline concentrations HPA axis activity, higher β2-adrenoreceptors mediate Thus, serve but cooperative roles orchestrate homing. report delineated darkness peaks norepinephrine, TNF-α, hormone melatonin, essential synchronized production repopulation HSPC pool [27Golan al.Daily differentially differentiation maintenance.Cell 23: 572-585Abstract (69) suggested there interplay processes mediated conjunction rely components clock. recruited series consecutive steps, beginning capture rolling along wall, followed induction firm adhesion, intraluminal crawling, transmigration bloodstream through barrier tissue [28Ley al.Getting site inflammation: cascade updated.Nat. 7: 678-689Crossref (3088) (Box 1). Leukocyte includes extravasation margination (Figure Key Figure). Endothelial cell-specific deletion (Cdh5–creERT2:Arntlflox) results abolished differences VCAM-1 ICAM-1, abrogates emphasizes significant impact endothelial-specific capacity. link directly promoter regions indirect, currently unknown. review organ-specific homeostasis rapidly growing field. Furthermore, delineate role diseases, intervention process.Box 1Leukocyte RecruitmentLeukocytes adhere endothelium PSGL-1 (P-selectin glycoprotein ligand 1) binds glycoproteins termed selectins (L-/P-/E-selectin). roll CXCL1 (chemokine CXC motif trigger G protein-coupled (e.g., CXCR2, 2). integrins LFA-1 (lymphocyte function-associated antigen 1 CD11a/CD18), Mac-1 (macrophage-1 CD11b/CD18) myeloid VLA-4 (very late 4 CD49d/CD29), interaction ICAM-1 ICAM-2 (intercellular 1/2), (vascular molecule mediating arrest vessels. Some first effector immunity neutrophils, make up predominant subset Under conditions, neutrophil oscillate [14Ella 29Casanova-Acebes al.Rhythmic modulation niche clearance.Cell. 153: 1025-1035Abstract (441) Human exhibit fluctuations CD11a, L-selectin, [30Niehaus G.D. variation cell-adhesion normal leukocytes.Can. Pharmacol. 2002; 80: 935-940Crossref (31) PSGL-1, CD29, CXCR2 has been (Figures 2 ). Neutrophils migrate lung, liver, spleen, mouse, evening 31Casanova-Acebes al.Neutrophils instruct homeostatic pathological states naive tissues.J. Exp. Med. 215: 2778-2795Crossref (150) elegant using parabiotic (with experimentally conjoined circulation) observation not previously associated infiltration lymph nodes (LNs) [31Casanova-Acebes phenomenon alter whole transcriptional profile affected suggesting modest amounts organ phenotypes. Rhythmic involves different combination specific organs: spleen requires CD49d liver relatively short lifespan, age over course single day, they upregulate addition CD11b while same losing L-selectin shedding [32Zhang al.Neutrophil ageing microbiome.Nature. 2015; 525: 528-532Crossref (483) marks clearance [29Casanova-Acebes Functional blockade antagonist AMD3100 marked reduction compared vehicle-treated controls. behavior established key types inflammation, investigations now identified routes conditions; consequently, known tropism expanded beyond accepted routes. total monocyte populations [33Cuesta al.Simulated night shift disrupts humans.J. 196: 2466-2475Crossref (80) (CD115+Ly6Chi) [16Nguyen non-inflammatory monocytes (CD115+Ly6Clo) numbers. Similarly resting reach minimum variations overall [34Chong S.Z. al.CXCR4 identifies transitional premonocytes replenish responses.J. 213: 2293-2314Crossref (72) although affecting parallel, express CCL2 manner. deficiency oscillation, leading impaired wild-type (WT) animals loss Lyz2–cre:Arntlflox proinflammatory phenotype, IL-6 cytokine controls; likely due acting brake type [35Gibbs J.E. REV-ERBalpha mediates selective cytokines.Proc. 109: 582-587Crossref (432) resulting predisposes low-grade chronic obesity data collectively demonstrate chemokines common subsets, eosinophil 36Acland J.D. Gould A.H. Normal count man.J. 1956; 456-466Crossref (17) 37Halberg F. al.Eosinophil mice: range occurrence; illumination, feeding, adrenalectomy.Am. 1953; 109-122Crossref (61) were described [36Acland targeting disrupting lung accumulation furthermore serum IL-5 [38Dent L.A. al.Eosinophilia expressing interleuki

Language: Английский

---

Endogenous Programs and Flexibility in Bird Migration

Frontiers in Ecology and Evolution, Journal Year: 2020, Volume and Issue: 8

Published: March 26, 2020

Endogenous programs that regulate annual cycles have been shown for many taxa, including protists, arthropods, fish, mammals and birds. In migration biology, these are best known in songbirds. The majority of songbirds rely on a genetic program inherited from their parents will guide them during first solo-migration. phenotypic components the crucial individual fitness survival, include time components, direction, distance. This is constructed to both behavior flexible responses environment at different stages cycle. driven by circannual rhythm, allowing for, resetting, carry-over effects. With experience, decisions migrants may be based information learnt breeding sites, wintering en route. At population level, substantial variation route choice timing explained interactions with environmental social factors, learning. this review we explore endogenous discuss what ways they can lead flexibility behavior.

Language: Английский

---

Chronobiology of interspecific interactions in a changing world

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2017, Volume and Issue: 372(1734), P. 20160248 - 20160248

Published: Oct. 9, 2017

Animals should time activities, such as foraging, migration and reproduction, well seasonal physiological adaptation, in a way that maximizes fitness. The fitness outcome of activities depends largely on their interspecific interactions; the temporal overlap with other species determines when they be active order to maximize encounters food minimize predators, competitors parasites. To cope constantly changing, but predictable structure environment, organisms have evolved internal biological clocks, which are synchronized mainly by light, most reliable environmental cue (but can masked variables), enable them anticipate prepare for predicted changes timing interact with, top responding directly. Here, we review examples where system is used predict interactions, how these interactions affect activity patterns. We then ask plastic mechanisms are, this plasticity differs between within variability affects changing world, major synchronizer clock, no longer owing rapidly climate, use artificial light urbanization. This article part themed issue ‘Wild clocks: integrating chronobiology ecology understand timekeeping free-living animals’.

Language: Английский

---

Circadian rhythmicity of body temperature and metabolism

Temperature, Journal Year: 2020, Volume and Issue: 7(4), P. 321 - 362

Published: March 16, 2020

This article reviews the literature on circadian rhythms of body temperature and whole-organism metabolism. The two are first described separately, each description preceded by a review research methods. Both generated endogenously but can be affected exogenous factors. relationship between is discussed next. In endothermic animals, modulation metabolic activity affect temperature, rhythm not mere side effect thermogenesis associated with general activity. system modulates heat production to generate rhythm, which challenges homeothermy does abolish it. Individual cells do regulate their own metabolism at cellular level also discussed. Metabolism both an output input clock, meaning that rhythmicity intertwined in cell.

Language: Английский

---

Migratory strategy drives species-level variation in bird sensitivity to vegetation green-up

Nature Ecology & Evolution, Journal Year: 2021, Volume and Issue: 5(7), P. 987 - 994

Published: April 29, 2021

Language: Английский

---

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(8), P. 3239 - 3256

Published: June 13, 2022

Abstract The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental autoimmune life quality change. Following this, some therapies have developed correct misalignments, such as light therapy chronobiotics. In this manuscript, we describe circadian‐related diseases so far investigated, studies reporting relevant data on topic, evidencing relationship, are included. Despite actual limitations in published work, there clear evidence correlation between disease origin/development, and, way, clock‐related emerge great progress clinical field. Future improvements interventions can lead development successful chronotherapy strategies, deeply contributing enhanced therapeutic outcomes.

Language: Английский

---

Daily activity timing in the Anthropocene

Trends in Ecology & Evolution, Journal Year: 2022, Volume and Issue: 38(4), P. 324 - 336

Published: Nov. 16, 2022

Language: Английский

---