Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame DOI Open Access
Xiaoxiao Zheng, Jiayuan Wang, Xi Yang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 26, 2023

Abstract Prosocial and moral behaviors have overlapping neural systems but whether they involve similar neurochemical is unclear. In the current pre-registered randomized placebo controlled trial on 180 adult male female subjects we investigated effects of intranasal administration two prosocial neuropeptides, oxytocin or vasopressin, emotion ratings for situations involving accidental intentional harm to others in judgments dilemmas where inflicted a greater good. Oxytocin, not enhanced feelings guilt shame only reduced endorsement choices direct could achieve Effects were partially mediated by trait empathy. Overall, findings demonstrate first time that oxytocin, promotes unwillingness deliberately irrespective consequences. This may reflect stronger associations between empathy vasopressin with aggression.

Language: Английский

Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame DOI Creative Commons
Xiaoxiao Zheng, Jiayuan Wang, Xi Yang

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(11), P. 3475 - 3482

Published: May 20, 2024

Abstract Prosocial and moral behaviors have overlapping neural systems can both be affected in a number of psychiatric disorders, although whether they involve similar neurochemical is unclear. In the current registered randomized placebo-controlled trial on 180 adult male female subjects, we investigated effects intranasal administration oxytocin vasopressin, which play key roles influencing social behavior, emotion ratings for situations involving harming others judgments dilemmas where are harmed greater good. Oxytocin, but not enhanced feelings guilt shame intentional accidental harm reduced endorsement intentionally to achieve Neither peptide influenced arousal scenarios. Effects were strongest individuals scoring lower personal distress subscale trait empathy. Overall, findings demonstrate first time that oxytocin, promotes unwillingness irrespective consequences. This may reflect associations between empathy vasopressin with aggression suggests therapeutic potential disorders atypical behavior.

Language: Английский

Citations

5
The interplay of oxytocin and sex hormones DOI Creative Commons
Daniel Quintana, Bernt Damian Glaser,

Heemin Kang

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105765 - 105765

Published: June 15, 2024

The neuropeptide oxytocin has historically been associated with reproduction and maternal behavior. However, more recent research uncovered that a much wider range of roles in physiology Despite the excitement surrounding potential therapeutical applications intranasally administered oxytocin, results these intervention studies have inconsistent. Various reasons for mixed proposed, which tend to focus on methodological issues, such as study design. While issues are certainly important, emerging evidence suggests interaction between sex hormones may also account varied findings. To better understand purpose function hormones, estrogens, progesterone, testosterone, we conducted comprehensive thematic review via four perspectives: evolutionary, developmental, mechanistic, survival. Altogether, this synergistic approach highlights critical hormone activity accomplishing diverse modulation release receptor activity, is likely contribute heterogeneity outcomes after administration.

Language: Английский

Citations

5
Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes DOI Open Access
Sarah Amato, Monica Averna, Diego Guidolin

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4677 - 4677

Published: Feb. 28, 2023

The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-OT receptor (OTR) receptor-receptor interaction in limbic is increasingly considered play roles social or emotional behavior, and suggested serve as a potential therapeutic target. Although astrocytes modulatory effects OT dopamine central nervous are well recognized, possibility D2-OTR has been neglected. In purified astrocyte processes from adult rat striatum, we assessed OTR D2 expression by confocal analysis. activation these receptors were evaluated neurochemical study glutamate release evoked 4-aminopyridine; heteromerization was co-immunoprecipitation proximity ligation assay (PLA). structure possible heterodimer estimated bioinformatic approach. We found that both expressed on same controlled glutamate, showing heteromers. Biochemical biophysical evidence confirmed heterodimers striatal astrocytes. residues transmembrane domains four five predicted be mainly involved heteromerization. conclusion, for astrocytic control glutamatergic synapse functioning modulation should taken into consideration when considering interactions between oxytocinergic systems striatum.

Language: Английский

Citations

12
Re‐wiring of the bonded brain: Gene expression among pair bonded female prairie voles changes as they transition to motherhood DOI Creative Commons
Santiago A. Forero,

Sydney Liu,

Netra Shetty

et al.

Genes Brain & Behavior, Journal Year: 2024, Volume and Issue: 23(3)

Published: June 1, 2024

Abstract Motherhood is a costly life‐history transition accompanied by behavioral and neural plasticity necessary for offspring care. in the monogamous prairie vole associated with decreased pair bond strength, suggesting trade‐off between parental investment maintenance. Neural mechanisms governing bonds maternal overlap, creating possible competition two. We measured mRNA expression of genes encoding receptors oxytocin ( oxtr ), dopamine d1r d2r mu‐opioids oprm1a kappa‐opioids oprk1a ) within three brain areas processing salience sociosensory cues (anterior cingulate cortex; ACC), bonding (nucleus accumbens; NAc), care (medial preoptic area; MPOA). compared gene differences bonded voles that were never pregnant, pregnant (~day 16 pregnancy), recent mothers (day 3 lactation). found greater NAc , MPOA following to motherhood. Expression all five ACC was greatest females had been longer. Gene each region highly correlated, indicating oxytocin, dopamine, opioids comprise complimentary network social signaling. ACC‐NAc correlations indicated being mother or maintaining long‐term relies on coordination different signaling systems same circuit. Our study suggests undergoes changes prepare face increased emotional offspring, while also bond.

Language: Английский

Citations

3
The interplay of oxytocin and sex hormones DOI Open Access
Daniel Quintana, Bernt Damian Glaser, Heemin Kang

et al.

Published: Jan. 23, 2024

The neuropeptide oxytocin has historically been associated with reproduction and maternal behavior. However, more recent research uncovered that a much wider range of roles in physiology Despite the excitement surrounding potential therapeutical applications intranasally administered oxytocin, results these intervention studies have inconsistent. Various reasons for mixed proposed, which tend to focus on methodological issues, such as study design. While issues are certainly important, emerging evidence suggests interaction between sex hormones may also account varied findings. To better understand purpose function hormones, estrogens, progesterone, testosterone, we conducted comprehensive thematic review via four perspectives: evolutionary, developmental, mechanistic, survival. Altogether, this synergistic approach highlights critical hormone activity accomplishing diverse modulation release receptor activity, is likely contribute heterogeneity outcomes after administration.

Language: Английский

Citations

2
Preliminary evidence of an increased susceptibility to face pareidolia in postpartum women DOI Creative Commons
Jessica Taubert,

Samantha Wally,

Barnaby Dixson

et al.

Biology Letters, Journal Year: 2023, Volume and Issue: 19(9)

Published: Sept. 1, 2023

As primates, we are hypersensitive to faces and face-like patterns in the visual environment, hence often perceive illusory otherwise inanimate objects, such as burnt pieces of toast surface moon. Although this phenomenon, known face pareidolia, is a common experience, it unknown whether our susceptibility pareidolia static across lifespan or what factors would cause change. Given evidence that behaviour towards stimuli modulated by neuropeptide oxytocin (OT), reasoned participants stages life associated with high levels endogenous OT might be more susceptible than other life. We tested hypothesis assessing two groups women; pregnant women (low OT) postpartum (high OT). found report seeing easily who currently pregnant. These data, collected online, suggest sensitivity not fixed may change throughout adulthood, providing crucial proof concept requires further research.

Language: Английский

Citations

4
Intranasal oxytocin interacts with testosterone reactivity to modulate parochial altruism DOI Creative Commons
Boaz R. Cherki, Eyal Winter,

David Mankuta

et al.

Communications Psychology, Journal Year: 2024, Volume and Issue: 2(1)

Published: March 9, 2024

The neuropeptide hormone oxytocin and the steroid testosterone have received attention as modulators of behavior in context intergroup conflict. However, to date, their interactive effect has yet be tested. Here, a double-blind placebo-control design, 204 participants (102 female participants) self-administrated or placebo completed an experimental economic game modeling Salivary (n = 192) was measured throughout task assess endogenous reactivity. As caveat, even at this sample size, our derived power detect small effects for 2- 3-way interactions relatively low. For male participants, changes predicted willingness sacrifice investments betterment group. Intranasal administration strongly diminished effect. In we found no credible evidence association between investments, rather, were independent testosterone. This interaction medium large size (Odds Ratio 5.11). Behavior also affected by social cues such signaling ingroup outgroup members. Our findings provide insights biological processes underpinning parochial altruism suggest additional path dual influence on human behavior.

Language: Английский

Citations

1
Oxytocin in Human Social Network Cooperation DOI
Xiaochun Han, Yina Ma

The Neuroscientist, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Human society is organized in structured social networks upon which large-scale cooperation among genetically unrelated individuals favored and persists. Such crucial for the success of human species but also one most puzzling challenges. Recent work behavioral neuroscience has linked to oxytocin, an evolutionarily ancient structurally preserved hypothalamic neuropeptide. This review aims elucidate how oxytocin promotes nonkin by reviewing its effects at three distinct levels: individual cooperation, formation interpersonal relationships, establishment heterogeneous network structures. We propose as a proximate mechanism fostering societies. Specifically, plays important role facilitating network-wide societies 1) increasing mitigating noncooperation motives, enforcement cooperative norms; 2) bonding synchronization; 3)

Language: Английский

Citations

1
Dissecting social decision-making: A spotlight on oxytocinergic transmission DOI Creative Commons
Giulia Coccia, Filippo La Greca, Mónica Di Luca

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: Dec. 22, 2022

Social decision-making requires the ability to balance both interests of self and others survive in social environments. Empathy is essential regulation this type interaction, it often sustains relevant prosocial behaviors such as altruism helping behavior. In last decade, our capacity assess affective empathy-like rodents has expanded understanding neurobiological substrates that underly processes behaviors. Within context, oxytocinergic transmission profoundly implicated modulating some major components decision-making. Thus, review will present evidence association between oxytocin nonhuman animals. Then, we dissect involvement transmission-across different brain regions pathways-in key elements emotional discrimination, recognition, contagion, dominance, memory. Evidence modulatory role on raised considerable interest its clinical relevance, therefore also discuss controversial findings intranasal administration.

Language: Английский

Citations

3
Social Behavior: Rituals and Social Bonding DOI
Sarah Jane Charles, Valerie van Mulukom

Published: Jan. 1, 2024

Language: Английский

Citations

0