Immune system, Journal Year: 2024, Volume and Issue: unknown, P. 99 - 129
Published: Nov. 8, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4857 - 4857
Published: Aug. 17, 2024
The prevalence of nonalcoholic fatty liver disease (NAFLD) is likely to be approaching 38% the world's population. It predicted become worse and main cause morbidity mortality due hepatic pathologies. particularly worrying that NAFLD increasingly diagnosed in children closely related, among other conditions, insulin resistance metabolic syndrome. Against this background concern awareness patients with low; one study, almost 96% adult USA were not aware their disease. Thus, studies on therapeutic tools used treat are extremely important. One promising treatment a well-formulated ketogenic diet (KD). aim paper present review available publications current state knowledge effect KD NAFLD. This includes characteristics key factors (from point view regression), which exerts its effects, i.e., reduction body weight, elimination fructose monosaccharides, limitation total carbohydrate intake, anti-inflammatory ketosis state, or modulation gut microbiome metabolome. In context evidence for effectiveness regression NAFLD, also suggests important role taking responsibility one's own health through increasing self-monitoring self-education.
Language: Английский
Citations
6
Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2394 - 2394
Published: March 7, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial disorder characterized by excessive lipid accumulation in the which dysregulates organ’s function. The key contributor to MASLD development insulin resistance (IR) affects many organs (including adipose tissue, skeletal muscles, and liver), whereas molecular background associated with oxidative, nitrosative, carbonyl stress. Among molecules responsible for stress effects, methylglyoxal (MGO) seems play major pathological MGO—a by-product of glycolysis, fructolysis, lipolysis (from glycerol fatty acids-derived ketone bodies)—is implicated hyperglycemia, hyperlipidemia, obesity, type 2 diabetes, hypertension, cardiovascular diseases. Its causative effect stimulation prooxidative proinflammatory pathways has been well documented. Since metabolic dysregulation leading these pathologies promotes MASLD, role MGO addressed this review. Potential participation mechanism discussed regard its different signaling routes events accelerating disorder. Moreover, treatment strategies including approved potential therapies are overviewed them, medications aimed at attenuating MGO-induced processes addressed.
Language: Английский
Citations
0
Applied Microbiology, Journal Year: 2025, Volume and Issue: 5(1), P. 31 - 31
Published: March 19, 2025
Background/Objectives: Uric acid (UA) levels vary based on gender, but elevated UA are linked to various health conditions in both sexes. Methods: This study examined the impact of a high-pectin smoothie (11.6 g fiber/day) consumption for 3 weeks and gut microbiota 28 healthy women. Food diaries, stool, blood samples were collected at baseline after consumption. Results: The participants with similar showed divergent responses: increased 15th participant (UAI group) decreased 13th (UAD post-intervention. Smoothie Bacteroides UAD Prevotella 9 UAI, contrasting abundances, where was higher UAI group. Furthermore, proportion Faecalibacterium group consumption, equalizing difference Conclusions: research highlights role personalized dietary strategies, noting that pectin managing women may rely their fiber intake.
Language: Английский
Citations
0
mBio, Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
ABSTRACT Fructose catabolism by Streptococcus mutans is initiated three phosphotransferase (PTS) transporters yielding fructose-1-phosphate (F-1-P) or fructose-6-phosphate. Deletion of one such F-1-P-generating PTS, fruI , was shown to reduce the cariogenicity S. in rats fed a high-sucrose diet. Moreover, recent study linked fructose metabolism reactive electrophile species methylglyoxal. Here, we conducted comparative transcriptomic analysis treated briefly with 50 mM fructose, glucose, 5 methylglyoxal, 0.5 hydrogen peroxide (H 2 O ). The results revealed striking overlap between and methylglyoxal transcriptomes, totaling 176 genes, 61 which were also shared H transcriptome. This core genes encompassed many same pathways affected exposure low pH zinc intoxication. Consistent these findings, negatively impacted metal homeostasis mutant deficient expulsion growth major oxidative stress regulator SpxA1. Importantly, lowered culture at faster pace, allowed better survival under acidic nutrient-depleted conditions, enhanced competitiveness against sanguinis although moderated level F-1-P might further boost some benefits. Conversely, several commensal streptococcal displayed greater sensitivity that may affect their persistence dental biofilm. In conclusion, integrated into regulates critical functions required for its ability induce dysbiosis oral cavity. IMPORTANCE common monosaccharide biosphere, yet overconsumption has been various health problems humans including insulin resistance, obesity, diabetes, non-alcoholic liver diseases, even cancer. These effects are large part attributable unique biochemical characteristics metabolic responses associated degradation fructose. Yet, an understanding on physiology bacteria implications human microbiome severely lacking. performed series analyses gene regulation pathogen exposing it other important agents. Further supported growth, persistence, competition assays, our findings activate set stress-related prove bacterium persist cause diseases both within without
Language: Английский
Citations
0
Published: April 20, 2025
Aim: Fructose is a highly lipogenic compound related to the onset of steatosis, its progression steatohepatitis, and eventual initiation hepatocellular carcinoma (HCC). One cancer hallmarks metabolic adaptation environmental sources; however, this characteristic could be exploited manipulate HCC tumor’s response therapies. Due high prevalence in consumption diets enriched with fructose unclear results literature, it pertinent characterize effects on biology as possible beneficial player aggressiveness cancer. We focused investigating effect liver cells chemotherapy response. Methods: treated Huh-7 HepG2 cell lines 1 mM address reprogramming fructose-induced effects. Results: Cancer use an alternative fuel source glucose-starved conditions, ensuring tumorigenic properties survival both lines. The differed depending line origin aggressiveness. Conclusions: showed under treatment, enhancing pentose phosphate pathway anabolism. Metabolic rewiring also improves chemoresistance vitro vivo, contributing failure cells.
Language: Английский
Citations
0
Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)
Published: April 20, 2025
Language: Английский
Citations
0
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: June 27, 2024
Background The study aimed to examine the association between systemic immune-inflammation index (SII), a contemporary metric of inflammatory response, and biological aging, which are closely interconnected processes. Methods This cross-sectional utilized 10 cycles data from NHANES database spanning 1990 2018. examined relationship SII index, calculated as P * N/L, where represents preoperative peripheral platelet count, N neutrophil L lymphocyte aging. Biological aging was assessed through various methods, such phenotypic age, age acceleration (PhenoAgeAccel), (BioAgeAccel). Correlations were analyzed using weighted linear regression subgroup analysis. Results Among 7,491 participants analyzed, average 45.26 ± 0.34 years, with 52.16% being female. ages 40.06 0.36 45.89 0.32 respectively. Following adjustment for potential confounders, elevated scores linked increased Phenotypic acceleration, acceleration. Positive correlations observed health behavior factor stronger associations seen factors. In factor-specific analyses, β coefficient notably higher high BMI. robust positive both in stratified analyses consistently across all strata. Conclusion evidence indicate that may serve valuable marker assessing different facets outcomes, mortality process. Additional research is warranted comprehensively elucidate implications process its utility clinical instrument evaluating addressing age-related ailments.
Language: Английский
Citations
3
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Aug. 19, 2024
Fructose consumption in pediatric subjects is rising, as the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). Despite increasing evidence supporting detrimental effects fructose development Metabolic Syndrome (MetS) its related comorbidities, association between intake remains unclear, mainly youths. The current narrative review aims to illustrate correlation metabolism functions besides impact on obesity MASLD pediatrics. involved through classical lipogenic pathway
Language: Английский
Citations
3