Invade or die: behaviours and biochemical mechanisms that drive skin penetration in Strongyloides and other skin-penetrating nematodes

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 379(1894)

Published: Nov. 27, 2023

Skin-penetrating nematodes, including the human threadworm Strongyloides stercoralis and hookworms in genera Necator Ancylostoma , are gastrointestinal parasites that a major cause of neglected tropical disease low-resource settings worldwide. These infect hosts as soil-dwelling infective larvae navigate towards using host-emitted sensory cues such odorants body heat. Upon host contact, they invade by penetrating through skin. The process skin penetration is critical for successful parasitism but remains poorly understood understudied. Here, we review current knowledge skin-penetration behaviour its underlying mechanisms parasite S. closely related rat ratti, other skin-penetrating nematodes hookworms. We also highlight important directions future investigations into this underexplored discuss how recent advances molecular genetic genomic tools species will enable mechanistic essential parasitic behaviours studies. This article part Theo Murphy meeting issue ‘ : omics to worm-free populations’.

Language: Английский

A standard workflow for community-driven manual curation ofStrongyloidesgenome annotations

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 379(1894)

Published: Nov. 27, 2023

Advances in the functional genomics and bioinformatics toolkits for Strongyloides species have positioned these as genetically tractable model systems gastrointestinal parasitic nematodes. As community interest mechanistic studies of continues to grow, publicly accessible reference genomes associated genome annotations are critical resources researchers. Genome multiple broadly available via WormBase ParaSite online repositories. However, a recent phylogenetic analysis receptor-type guanylate cyclase (rGC) gene family two highlights potential errors large percentage current models. Here, we present three examples annotation updates within rGC family; each example illustrates type error that may occur frequently data genomes. We also extend our 405 previously curated genes confirm found at high rates across families. Finally, introduce standard manual curation workflow assessing quality generating corrections, discuss how it be used facilitate community-driven nematode biodata. This article is part Theo Murphy meeting issue 'Strongyloides: omics worm-free populations'.

Language: Английский

Strongyloides: omics to worm-free populations

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 379(1894)

Published: Nov. 27, 2023

This article is part of the Theo Murphy meeting issue ‘ Strongyloides : omics to worm-free populations’.

Language: Английский