The connectome of the adult Drosophila mushroom body provides insights into function

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Dec. 14, 2020

Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with direct connections descending neurons. We find unexpected structure sensory inputs, transfer information different modalities MBONs, modulation that dopaminergic (DANs). provide insights into circuitry used integrate outputs, between central complex inputs DANs, feedback MBONs. Our results a foundation further theoretical work.

Language: Английский

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A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

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Sexual arousal gates visual processing during Drosophila courtship

Nature, Journal Year: 2021, Volume and Issue: 595(7868), P. 549 - 553

Published: July 7, 2021

Language: Английский

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Transforming representations of movement from body- to world-centric space

Nature, Journal Year: 2021, Volume and Issue: 601(7891), P. 98 - 104

Published: Dec. 15, 2021

Language: Английский

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Brainstem Circuits for Locomotion

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 63 - 85

Published: Jan. 5, 2022

Locomotion is a universal motor behavior that expressed as the output of many integrated brain functions. organized at several levels nervous system, with brainstem circuits acting gate between areas regulating innate, emotional, or motivational locomotion and executive spinal circuits. Here we review recent advances on involved in controlling locomotion. We describe how delineated command govern start, speed, stop, steering also discuss these pathways interface cord diverse important for context-specific selection A recurrent theme need to establish functional connectome from Finally, point unresolved issues concerning function locomotor control.

Language: Английский

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A neural circuit for wind-guided olfactory navigation

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 8, 2022

Abstract To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction location. Where and how these two are integrated to support navigation is unclear. Here we describe pathway the Drosophila fan-shaped body that encodes attractive promotes upwind navigation. We show neurons throughout this encode odor, but not direction. Using connectomics, identify local called h∆C receive input from previously described pathway. exhibit odor-gated, direction-tuned activity, sparse activation of in reproducible direction, activity required for persistent orientation during odor. Based on connectome data, develop computational model showing can promote goal such as an source. Our results suggest processed by separate pathways within goal-directed

Language: Английский

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Ascending neurons convey behavioral state to integrative sensory and action selection brain regions

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(4), P. 682 - 695

Published: March 23, 2023

Knowing one's own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to brain are well positioned provide such signals. However, what ANs encode where they convey these signals remains largely unknown. Here, through large-scale functional imaging behaving animals morphological quantification, we report encoding targeting of hundreds genetically identifiable adult fly, Drosophila melanogaster. We reveal states, specifically conveying self-motion anterior ventrolateral protocerebrum, an integrative hub, discrete actions gnathal ganglia, a locus action selection. Additionally, AN projection patterns within predictive their encoding. Thus, ascending populations poised inform distinct hubs ongoing behaviors may important substrate computations required adaptive behavior.

Language: Английский

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Converting an allocentric goal into an egocentric steering signal

Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 808 - 818

Published: Feb. 7, 2024

Neuronal signals that are relevant for spatial navigation have been described in many species

Language: Английский

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Transforming a head direction signal into a goal-oriented steering command

Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 819 - 826

Published: Feb. 7, 2024

To navigate, we must continuously estimate the direction are headed in, and correct deviations from our goal

Language: Английский

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Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

Published: March 18, 2024

In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type developmental lineage annotation (Marin which provides complete VNC connectivity at synaptic resolution. Here, present first look organization networks connecting DNs based on this new information. We proofread curated all ensure accuracy reliability, then systematically matched DN axon terminals MN dendrites with light microscopy data link their morphology inputs or muscle targets. report both broad organizational patterns entire network fine-scale analysis selected interest. discover direct DN-MN connections infrequent identify communities intrinsic linked control different systems, putative for walking, dorsal flight steering power generation, intermediate lower tectulum coordinated action wings legs. Our generates hypotheses future functional experiments and, together MANC connectome, empowers others investigate richer mechanistic detail.

Language: Английский

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