Pathways to altered virulence of SARS-CoV-2 DOI Open Access
Laura F. White, Debra Van Egeren, Madison Stoddard

et al.

Published: Feb. 24, 2023

The recently emerged SARS-CoV-2 virus has led to a prolonged pandemic characterized by ongoing viral evolution. Vaccines have been an important piece in the strategy combat but insufficient contain it as continues evolve evade immunity developed vaccination and infection. A consistent argument is that or prior will lead less severe infections. In this review, we address question of whether can become more virulent, despite We describe intrinsic characteristics their relationship altered virulence. show likely evolution subject evolutionary drift, cannot be assumed necessarily offer durable protection against disease. This strong implications for public health strategies confront challenges presented implies there are significant risks based on assumption waning

Language: Английский

Vaccines alone cannot slow the evolution of SARS-CoV-2 DOI Creative Commons
Debra Van Egeren, Madison Stoddard, Laura F. White

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 6, 2022

Abstract The rapid emergence of immune-evading viral variants SARS-CoV-2 calls into question the practicality a vaccine-only public health strategy for managing ongoing COVID-19 pandemic. It has been suggested that widespread vaccination is necessary to prevent future mutants. Here we examine proposition using stochastic computational models transmission and mutation. Specifically, look at likelihood immune escape requiring multiple mutations, impact on this process. Our results suggest rate intermediate mutants will which novel appear. While can lower new appear, other interventions reduce also have same effect. Crucially, relying solely repeated (vaccinating entire population times year) not sufficient strains if rates remain high within population. Thus, vaccines alone are incapable slowing pace evolution evasion, vaccinal protection against severe fatal outcomes patients therefore assured.

Language: Английский

Citations

4
Pathways to altered virulence of SARS-CoV-2 DOI Open Access
Laura F. White, Debra Van Egeren, Madison Stoddard

et al.

Published: Feb. 24, 2023

The recently emerged SARS-CoV-2 virus has led to a prolonged pandemic characterized by ongoing viral evolution. Vaccines have been an important piece in the strategy combat but insufficient contain it as continues evolve evade immunity developed vaccination and infection. A consistent argument is that or prior will lead less severe infections. In this review, we address question of whether can become more virulent, despite We describe intrinsic characteristics their relationship altered virulence. show likely evolution subject evolutionary drift, cannot be assumed necessarily offer durable protection against disease. This strong implications for public health strategies confront challenges presented implies there are significant risks based on assumption waning

Language: Английский

Citations

1