Parallels and contrasts between the cnidarian and bilaterian maternal-to-zygotic transition are revealed in Hydractinia embryos

PLoS Genetics, Journal Year: 2023, Volume and Issue: 19(7), P. e1010845 - e1010845

Published: July 13, 2023

Embryogenesis requires coordinated gene regulatory activities early on that establish the trajectory of subsequent development, during a period called maternal-to-zygotic transition (MZT). The MZT comprises transcriptional activation embryonic genome and post-transcriptional regulation egg-inherited maternal mRNA. Investigation into in animals has focused almost exclusively bilaterians, which include all classical models such as flies, worms, sea urchin, vertebrates, thus limiting our capacity to understand paradigms uniting across animals. Here, we elucidate non-bilaterian, cnidarian Hydractinia symbiolongicarpus. Using parallel poly(A)-selected non poly(A)-dependent RNA-seq approaches, find is composed similar many including cytoplasmic readenylation maternally contributed mRNA, delayed activation, separate phases mRNA deadenylation degradation likely depend both zygotically encoded clearance factors, microRNAs. But also observe massive upregulation histone genes an expanded repertoire predicted H4K20 methyltransferases, aspects far particular potentially underlying novel mode chromatin regulation. Thus, strategies with taxon-specific elaboration underlie bilaterian non-bilaterian embryos, providing insight how essential developmental may have arisen ancestral

Language: Английский

Parallels and contrasts between the cnidarian and bilaterian maternal-to-zygotic transition are revealed inHydractiniaembryos

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 10, 2023

Embryogenesis requires coordinated gene regulatory activities early on that establish the trajectory of subsequent development, during a period called maternal-to-zygotic transition (MZT). The MZT comprises transcriptional activation embryonic genome and post-transcriptional regulation egg-inherited maternal mRNA. Investigation into in animals has focused almost exclusively bilaterians, which include all classical models such as flies, worms, sea urchin, vertebrates, thus limiting our capacity to understand paradigms uniting across animals. Here, we elucidate non-bilaterian, cnidarian

Language: Английский