Subthreshold intracortical microstimulation of human somatosensory cortex enhances tactile sensitivity DOI Open Access
Luke E. Osborn, Breanne Christie, David P. McMullen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

ABSTRACT Intracortical microstimulation (ICMS) of the somatosensory cortex activates neurons around stimulating electrodes and can elicit tactile sensations. However, it is not clear how direct activation cortical influences their ability to process additional inputs originating from skin. In a human implanted with chronic microelectrode arrays in both left right cortices, we presented mechanical vibration skin while simultaneously delivering ICMS quantified effects combined electrical stimulation on perception. We found that subthreshold enhanced sensitivity touch skin, as evidenced by reduction vibrotactile detection thresholds (median: −1.5 dB), but did systematically impact detectability ICMS. Suprathreshold led an increase 2.4 dB) suprathreshold had little thresholds. The ICMS-induced enhancement was location dependent effect size decreasing projected field electrode locus vibratory became farther apart. These results demonstrate targeted alone focally enhance sensitivity, potentially enabling restoration or strengthening retained sensations after injury.

Language: Английский

Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation DOI Creative Commons
Giacomo Valle, Natalija Katic,

Dominic Eggemann

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 20, 2024

Abstract Artificial communication with the brain through peripheral nerve stimulation shows promising results in individuals sensorimotor deficits. However, these efforts lack an intuitive and natural sensory experience. In this study, we design test a biomimetic neurostimulation framework inspired by nature, capable of “writing” physiologically plausible information back into nervous system. Starting from in-silico model mechanoreceptors, develop policies. We then experimentally assess them alongside mechanical touch common linear neuromodulations. Neural responses resulting neuromodulation are consistently transmitted towards dorsal root ganglion spinal cord cats, their spatio-temporal neural dynamics resemble those naturally induced. implement paradigms within bionic device it patients (ClinicalTrials.gov identifier NCT03350061). He report that improves mobility (primary outcome) reduces mental effort (secondary compared to traditional approaches. The outcomes neuroscience-driven technology, human body, may serve as for advancing assistive neurotechnologies.

Language: Английский

Citations

32
Tactile edges and motion via patterned microstimulation of the human somatosensory cortex DOI
Giacomo Valle, Ali H. Alamri, John E. Downey

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6731), P. 315 - 322

Published: Jan. 16, 2025

Intracortical microstimulation (ICMS) of somatosensory cortex evokes tactile sensations whose properties can be systematically manipulated by varying stimulation parameters. However, ICMS currently provides an imperfect sense touch, limiting manual dexterity and experience. Leveraging our understanding how features are encoded in the primary (S1), we sought to inform individuals with paralysis about local geometry apparent motion objects on their skin. We simultaneously delivered through electrodes spatially patterned projected fields (PFs), evoking edges. then created complex PFs that encode arbitrary shapes skin indentation patterns. By delivering spatiotemporally ICMS, evoked sensation across skin, speed direction which could controlled. Thus, improved individuals’ experience use brain-controlled bionic hands.

Language: Английский

Citations

6
Biomimetic multi-channel microstimulation of somatosensory cortex conveys high resolution force feedback for bionic hands DOI Creative Commons
Charles M. Greenspon, Giacomo Valle, Taylor E. Hobbs

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 18, 2023

Manual interactions with objects are supported by tactile signals from the hand. This feedback can be restored in brain-controlled bionic hands via intracortical microstimulation (ICMS) of somatosensory cortex (S1). In ICMS-based feedback, contact force signaled modulating stimulation intensity based on output sensors hand, which turn modulates perceived magnitude sensation. present study, we gauged dynamic range and precision three human participants implanted arrays microelectrodes S1. To this end, measured increases sensation resulting ICMS amplitude participant's ability to distinguish between different levels. We then assessed whether could improve fidelity implementing "biomimetic" ICMS-trains, designed evoke patterns neuronal activity that more closely mimic those natural touch, delivering through multiple channels at once. found multi-channel biomimetic gives rise stronger distinguishable sensations than does its single-channel counterpart. Finally, implemented a hand had participant perform compliance discrimination task. yielded improved over linear conclude conveys finely graded approximates sensitivity conferred touch.

Language: Английский

Citations

28
The state of clinical trials of implantable brain–computer interfaces DOI
K. Michelle Patrick-Krueger, Ian Burkhart, José L. Contreras-Vidal

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Language: Английский

Citations

11
A roadmap for implanting microelectrode arrays to evoke tactile sensations through intracortical microstimulation DOI
John E. Downey, Hunter R. Schone, Stephen T. Foldes

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 28, 2024

Abstract Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of bidirectional brain-computer interface restore upper limb function. Evoking tactile sensations the hand through ICMS requires precise targeting implanted electrodes. Here we describe presurgical imaging procedures used generate functional maps area somatosensory cortex and subsequent planning that guided implantation intracortical microelectrode arrays. In five participants cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked localized at least first four digits hand. The developed clinical trial provide roadmap other studies ensure successful placement stimulation

Language: Английский

Citations

6
Multi-Electrode ICMS Enables Dexterous Use of Bionic Hands DOI
Natalya Shelchkova, Giacomo Valle, Taylor E. Hobbs

et al.

Springer briefs in electrical and computer engineering, Journal Year: 2025, Volume and Issue: unknown, P. 29 - 37

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biomimetic BCI Conveys Naturalistic Touch Sensations Via Peripheral Nerve Stimulation for Bionic Legs DOI
Giacomo Valle, Natalija Katic,

T. Stielglitz

et al.

Springer briefs in electrical and computer engineering, Journal Year: 2025, Volume and Issue: unknown, P. 81 - 92

Published: Jan. 1, 2025

Language: Английский

Citations

0
Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes DOI Creative Commons
Brandon M. Ruszala, Marc H. Schieber

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115664 - 115664

Published: May 1, 2025

Language: Английский

Citations

0
Optimization frameworks for bespoke sensory encoding in neuroprosthetics DOI Creative Commons
F. Joel W.-M. Leong, Silvestro Micera, Solaiman Shokur

et al.

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(2)

Published: May 20, 2025

Restoring natural sensation via neuroprosthetics relies on the possibility of encoding complex and nuanced information. For example, an ideal brain–machine interface with sensory feedback would provide user about movement, pressure, curvature, texture, etc. Despite advances in neural interfaces that allow for stimulation patterns (e.g., multisite or targeting a precise ensemble), key question remains: How can we best exploit potential these technologies? The increasing number electrodes coupled more parameters being explored leads to exponential increase possible combinations, making brute-force approach, such as systematic search, impractical. This Perspective outlines three different optimization frameworks—namely, explicit, physiological, self-optimized methods—allowing one potentially converge faster toward effective parameters. Although our focus will be somatosensory system, frameworks are flexible applicable various systems vision) stimulator types.

Language: Английский

Citations

0
TACTILE EDGES AND MOTION VIA PATTERNED MICROSTIMULATION OF THE HUMAN CORTEX DOI Creative Commons
Giacomo Valle, Ali H. Alamari, Robin Lienkämper

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Intracortical microstimulation (ICMS) of somatosensory cortex evokes tactile sensations whose location and properties can be systematically manipulated by varying the electrode stimulation parameters 1–3 . This phenomenon used to convey feedback from a brain-controlled bionic hand about object interactions. However, ICMS currently provides an impoverished sense touch, limiting dexterous manipulation conscious experience neuroprosthetic systems. Leveraging our understanding how these sensory features are encoded in S1 4,5 , we sought expand repertoire ICMS-based artificial touch provide information local geometry motion objects individuals with paralysis. First, simultaneously delivered through multiple, spatially patterned electrodes, adopting specific arrangements aligned projected fields (PFs). Unprompted, participants reported sensation edge. Next, created more complex PFs found that could intuitively perceive arbitrary shapes skin indentation patterns. By delivering sequentially electrodes discontinuous PFs, even evoke across skin, direction speed which were able manipulate. We conclude appropriate spatiotemporal patterning inspired coding sensations. Our findings serve push boundaries thereby enriching participants’ simple percepts highly informative mimic natural touch.

Language: Английский

Citations

3