SARS-CoV-2 Infection Is Associated with an Accelerated eGFR Decline in Kidney Transplant Recipients up to Four Years Post Infection

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1091 - 1091

Published: April 25, 2025

Background/Objectives: Although kidney transplant recipients (KTRs) who are immune-compromised have been shown to be at high risk of adverse acute COVID-19 outcomes (i.e., mortality and critical illness), the long-term KTRs with a history SARS-CoV-2 infection unknown. We aimed compare without exposure SARS-CoV-2. Methods: This study retrospectively evaluated 1815 in Montefiore Health System from 4 January 2001 31 2024. The final cohorts consisted survived (n = 510) matched 510, controls). Outcomes were defined as all-cause changes estimated glomerular filtration rate (eGFR) urine protein creatinine ratio (UPCR) 30 days up four years post index date. Kaplan–Meier survival analysis Cox proportional modeling performed for mortality. Generalized estimating equations used analyze eGFR UPCR across time. Results: There was no significant group difference (adjusted hazard 0.66, [0.43, 1.01] p 0.057). controls patients before similarly decreased −0.98 units/year [−1.50, −0.46]. By contrast, declined significantly greater (−1.80 [−2.45, −1.15]) after compared COVID-19. association only seen among male not female KTRs. status associated change or rejection rate. Conclusions: an accelerated decline infection, suggesting potential implications graft health. These findings underscore importance vigilant monitoring management function this vulnerable population.

Language: Английский

---

A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1168 - 1168

Published: May 31, 2024

Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses;

Language: Английский

---

Mortality and COVID Infection: Predictors of Mortality 10 Months after Discharge

Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 123 - 123

Published: June 5, 2024

Background: The long-term survival of patients hospitalized with COVID-19 and the factors associated poorer months after infection are not well understood. aims present study were to analyze overall mortality 10 admission. Methods: 762 disease included. Patients underwent a complete clinical evaluation, routine laboratory analysis chest X-ray. Data collected included demographic data, such as vascular risk factors, tobacco or alcohol use, comorbidity, institutionalization. Results: Ten-month was 25.6%: 108 deaths occurred in-hospital, while 87 died discharge. In-hospital independently related NT-proBNP values > 503.5 pg/mL [OR = 4.67 (2.38–9.20)], urea 37 mg/dL [3.21 (1.86–7.31)] age older than 71 years 1.93 (1.05–3.54)]. 5.00 (3.06–8.19)], [3.51 (1.97–6.27)], cognitive impairment 1.96 (1.30–2.95), cancer 2.23 (1.36–3.68), leukocytes 6330/mm3 1.64 (1.08–2.50)], mortality. Conclusions: death remains high even infection. Overall during hospital discharge is nearly that observed Comorbidities impairment, organ dysfunction inflammatory reaction independent prognostic markers

Language: Английский

---

Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2774 - 2774

Published: Dec. 10, 2024

Although COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those essential tremor (ET) remains unclear. To investigate clinical of ET and without three a half years post-pandemic. 1074 were evaluated this retrospective study the Montefiore Health System from January 2016 July 2023. Comparisons between positive SARS-CoV-2 polymerase chain reaction test made. Outcomes included post-index date major adverse cardiovascular events (MACEs), new-onset sleep disturbances, fatigue, dyspnea, first-time fall, anxiety, depression, headache, imbalance, mild cognitive impairment, all-cause mortality, adjusted hazard ratios (aHR) adjusting for covariates calculated. had higher prevalence pre-existing type-2 diabetes, anxiety compared COVID-19. was significantly associated risk MACEs, (aHR = 2.39 [1.49, 3.82]), disturbance, 2.12 [1.44, 3.13]), 1.83 [1.27, 2.65]), 1.98 [1.40, 2.80]), 4.76 [2.24, 10.14]), 3.66 [2.02, 6.64]), 2.38 [1.20, 4.70]). not mortality. In ET, increases several long-term health outcomes, but

Language: Английский

---