In Parkinson's disease, affective and chronic fatigue syndrome symptoms are associated with neuronal damage markers. DOI Creative Commons
Hussein Kadhem Al‐Hakeim,

Hayder Naji Khudhair,

Sayed-Omid Ranaei-Siadat

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Background Parkinson’s disease (PD) is frequently accompanied by mood and chronic fatigue syndrome (CFS) symptoms. It unknown whether immune activation insulin resistance (IR) or brain injuries impacts the severity of affective CFS symptoms due to PD. Aims To examine immune, IR, and/or injury biomarkers determine Methods Using a case (70 PD patients) control (60 healthy controls) study design, we assessed symptoms, measured peripheral immune-inflammatory response system (IRS) using interleukin-6 (IL-6), IL-10, zinc, calcium levels, Homeostasis Model Assessment 2 (HOMA2IR) index, serum markers including S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), phosphorylated tau217 (pTau217), glial fibrillary acidic (GFAP). Results patients showed increased scores, IRS activation, HOMA2IR, NSE, GFAP, pTau217, S100B levels as compared controls. A large part (52.5%) variance in mood+CFS score was explained regression on S100B, HOMA2IR interleukin-10 (IL-10) (all positively) (inversely). The indices were significantly associated with all 4 biomarkers. latter (37.0%) cumulative effects indices. Discussion RS IR contribute damage cell projections type III intermediate filament, which turn

Language: Английский

Anxiety due to Long COVID is partially driven by activation of the tryptophan catabolite (TRYCAT) pathway DOI
Hussein Kadhem Al‐Hakeim,

Anwar Khairi Abed,

Abbas F. Almulla

et al.

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 88, P. 103723 - 103723

Published: Aug. 7, 2023

Language: Английский

Citations

12
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α+β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA / IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r=0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Citations

12
What Long COVID investigators can learn from four decades of ME/CFS research DOI Creative Commons
Leonard A. Jason, Benjamin H. Natelson, Hector Bonilla

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2023, Volume and Issue: 4, P. 100022 - 100022

Published: Sept. 7, 2023

Four decades of research in the field Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have yielded lessons that may be instructive for those devising criteria to better comprehend Post-Acute Sequelae SARS CoV-2 Infection (PASC) and Long COVID. For instance, substantial effort has been devoted defining classification systems, operationalizing methods, developing instruments with adequate reliability validity ME/CFS field. The current article provides guidelines a case definition COVID discusses significance psychometric issues criterion variance, including how specify symptoms, develop thresholds, subtypes, exclusionary conditions. could enhance our knowledge pathophysiology, early diagnosis, prognosis, identification effective treatments.

Language: Английский

Citations

7
Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 82 studies comprising 58 cytokines/chemokines/growth factors DOI Creative Commons
Abbas F. Almulla,

Yanin Thipakorn,

Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 8, 2024

Abstract Background Multiple studies have shown that Long COVID (LC) disease is associated with heightened immune activation, as evidenced by elevated levels of inflammatory mediators. However, there no comprehensive meta-analysis focusing on activation the response system (IRS) and compensatory immunoregulatory (CIRS) along other phenotypes in LC patients. Objectives This designed to explore IRS CIRS profiles patients, individual cytokines, chemokines, growth factors, C-reactive protein (CRP) immune-associated neurotoxicity. Methods To gather relevant for our research, we conducted a thorough search using databases such PubMed, Google Scholar, SciFinder, covering all available literature up December 20th, 2023. Results The current encompassed 82 examined multiple profiles, protein, 58 cytokines/chemokines/growth factors 3836 patients versus 4537 normal controls (NC). showed significant increases IRS/CIRS ratio (standardized mean difference (SMD:0.156, confidence interval (CI): 0.051;0.261), (SMD: 0.345, CI: 0.222;0.468), M1 macrophage 0.421, 0.290;0.551), T helper (Th)1 0.353, 0.189;0.517), Th17 0.492, 0.332;0.651) neurotoxicity 0.327 0.205;0.448). In addition, CRP 19 different cytokines displayed significantly compared NC. Conclusion characterized increased

Language: Английский

Citations

1
Editorial: Neuropsychiatric and neurodegenerative aspects of acute and long COVID DOI Creative Commons
Abbas F. Almulla, Hussein Kadhem Al‐Hakeim

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Dec. 12, 2023

EDITORIAL article Front. Mol. Neurosci., 12 December 2023Sec. Brain Disease Mechanisms Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1343930

Language: Английский

Citations

2
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α + β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA/IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r = 0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Citations

0
In Parkinson's disease, affective and chronic fatigue syndrome symptoms are associated with neuronal damage markers. DOI Creative Commons
Hussein Kadhem Al‐Hakeim,

Hayder Naji Khudhair,

Sayed-Omid Ranaei-Siadat

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Background Parkinson’s disease (PD) is frequently accompanied by mood and chronic fatigue syndrome (CFS) symptoms. It unknown whether immune activation insulin resistance (IR) or brain injuries impacts the severity of affective CFS symptoms due to PD. Aims To examine immune, IR, and/or injury biomarkers determine Methods Using a case (70 PD patients) control (60 healthy controls) study design, we assessed symptoms, measured peripheral immune-inflammatory response system (IRS) using interleukin-6 (IL-6), IL-10, zinc, calcium levels, Homeostasis Model Assessment 2 (HOMA2IR) index, serum markers including S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), phosphorylated tau217 (pTau217), glial fibrillary acidic (GFAP). Results patients showed increased scores, IRS activation, HOMA2IR, NSE, GFAP, pTau217, S100B levels as compared controls. A large part (52.5%) variance in mood+CFS score was explained regression on S100B, HOMA2IR interleukin-10 (IL-10) (all positively) (inversely). The indices were significantly associated with all 4 biomarkers. latter (37.0%) cumulative effects indices. Discussion RS IR contribute damage cell projections type III intermediate filament, which turn

Language: Английский

Citations

0