Homeostasis of cytoplasmic crowding by cell wall fluidization and ribosomal counterions DOI Creative Commons
Markus Basan, Avik Mukherjee, Yanqing Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

In bacteria, algae, fungi, and plant cells, the wall must expand in concert with cytoplasmic biomass production, otherwise cells would experience toxic molecular crowding

Language: Английский

Effects of induced electric field on the sensitivity of a two-compartment neuron model DOI Creative Commons

Yuan Chunhua,

R.B. Chen,

Xiangyu Li

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0324523 - e0324523

Published: May 20, 2025

Sensitivity is one of the key characteristics neurons in response to external stimuli. This study based on a two-compartment Pinsky-Rinzel neuron model, which has been modified under influence direct current induced electric field(DC-IEF). The research explores how this model encodes stimuli from DC-IEF, aiming assess its sensitivity firing field. Based structural PR neuron, parameters are altered specific stimulation identify state bifurcation points at different parameters. At these points, DC-IEF applied, and planar graph constructed illustrate relationship among rate, parameters, field intensity. Through analysis obtained data, it was found that exhibit DC-IEF. Furthermore, significantly affect their state.

Language: Английский

Citations

0
Mechanochemical control systems regulating animal cell size DOI
Heather E. Rizzo, Andy L Zhang, Margaret L. Gardel

et al.

Current Opinion in Cell Biology, Journal Year: 2024, Volume and Issue: 91, P. 102443 - 102443

Published: Nov. 6, 2024

Language: Английский

Citations

1
A universal mechanism of biomass density homeostasis via ribosomal counterions DOI Creative Commons
Avik Mukherjee, Yanqing Huang, Seungeun Oh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

In bacteria, algae, fungi, and plant cells, the wall must expand in concert with cytoplasmic biomass production, otherwise cells would experience toxic molecular crowding 1 , 2 or lyse. But how achieve expansion of this complex biomaterial coordination biosynthesis macromolecules cytoplasm remains unexplained 3 although recent works have revealed that these processes are indeed coupled 4,5 . Here, we report a striking increase turgor pressure growth rate E. coli suggesting speed cell is controlled via turgor. Remarkably, despite pressure, cellular density constant across wide range rates. By contrast, perturbations deviate from scaling directly alter density. A mathematical model based on fluidization by endopeptidases not only explains apparently confounding observations but makes surprising quantitative predictions validated experimentally. The picture emerges counterions ribosomal RNA. Elegantly, coupling between rRNA simultaneously coordinates rates exerts homeostatic feedback control This mechanism may regulate microbes to plants has important implications for action antibiotics 6

Language: Английский

Citations

2
Homeostasis of cytoplasmic crowding by cell wall fluidization and ribosomal counterions DOI Creative Commons
Markus Basan, Avik Mukherjee, Yanqing Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

In bacteria, algae, fungi, and plant cells, the wall must expand in concert with cytoplasmic biomass production, otherwise cells would experience toxic molecular crowding

Language: Английский

Citations

0