Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants DOI Creative Commons
Laura Thümmler, Nadine Beckmann,

Carolin Sehl

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 545 - 545

Published: March 30, 2024

The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent challenge for the global system. In particular, individuals in developing countries with insufficient care need easily accessible, affordable effective treatments of COVID-19. Previous studies have demonstrated efficacy functional inhibitors acid sphingomyelinase against infections various viruses, including early SARS-CoV-2. This work investigated whether fluoxetine sertraline, usually used as antidepressant molecules clinical practice, can inhibit replication former recently emerged vitro. Fluoxetine sertraline potently inhibited infection pseudotyped virus-like particles D614G, alpha, delta, omicron BA.1 BA.5. These results highlight priority candidates large-scale phase 3 trials at different stages infections, either alone or combination other medications.

Language: Английский

Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV) DOI Creative Commons
Phrutsamon Wongnak, William HK Schilling, Podjanee Jittamala

et al.

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(9), P. 953 - 963

Published: April 24, 2024

Effective antiviral drugs prevent hospitalisation and death from COVID-19. Antiviral efficacy can be efficiently assessed in vivo by measuring rates of SARS-CoV-2 clearance estimated serial viral genome densities quantitated nasopharyngeal or oropharyngeal swab eluates. We conducted an individual patient data meta-analysis unblinded arms the PLATCOV platform trial to characterise changes kinetics infer optimal design interpretation pharmacometric evaluations.

Language: Английский

Citations

6
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants DOI Open Access
Laura Thümmler, Nadine Beckmann,

Caroline Sehl

et al.

Published: March 4, 2024

The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent challenge for the global system. In particular, individuals in developing countries with insufficient care need easily accessible, affordable effective treatments of COVID-19. Previous studies have demonstrated efficacy functional inhibitors acid sphingomyelinase (FIASMA) against infections various viruses, including early SARS-CoV-2. This work investigated whether fluoxetine sertraline, usually used as antidepressant molecules clinical practice, can inhibit replication former recently emerged vitro. Fluoxetine sertraline potently inhibited infection pseudotyped virus like particles D614G, alpha, delta, omicron BA.1 BA.5. These results highlight priority candidates large-scale phase 3 trials at different stages infections, either alone or combination other medications.

Language: Английский

Citations

1
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants DOI Creative Commons
Laura Thümmler, Nadine Beckmann,

Carolin Sehl

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 545 - 545

Published: March 30, 2024

The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent challenge for the global system. In particular, individuals in developing countries with insufficient care need easily accessible, affordable effective treatments of COVID-19. Previous studies have demonstrated efficacy functional inhibitors acid sphingomyelinase against infections various viruses, including early SARS-CoV-2. This work investigated whether fluoxetine sertraline, usually used as antidepressant molecules clinical practice, can inhibit replication former recently emerged vitro. Fluoxetine sertraline potently inhibited infection pseudotyped virus-like particles D614G, alpha, delta, omicron BA.1 BA.5. These results highlight priority candidates large-scale phase 3 trials at different stages infections, either alone or combination other medications.

Language: Английский

Citations

1