Extracellular vesicles as the next‐generation modulators of pharmacokinetics and pharmacodynamics of medications and their potential as adjuvant therapeutics DOI Creative Commons
J. Liu, Joel Z. Nordin, Andrew J. McLachlan

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(8)

Published: Aug. 1, 2024

Pharmacokinetics (PK) and pharmacodynamics (PD) are central concepts to guide the dosage administration of drug therapies essential consider for both healthcare professionals researchers in therapeutic planning discovery. PK/PD properties a significantly influence variability response treatment, including failure or excessive medication-related harm. Furthermore, suboptimal PK constitute significant barrier further development some candidate treatments This article describes how extracellular vesicles (EVs) affect different aspects PD medications their potential modulate address problematic profiles drugs. We reviewed EVs' intrinsic effects on cell behaviours medication responses. also described surface cargo modifications can enhance EV functionalities enable them as adjuvants optimise profile conventional medications. we demonstrated that various bioengineering strategies be used modify EVs, hence enhancing

Language: Английский

Extracellular vesicles as the next‐generation modulators of pharmacokinetics and pharmacodynamics of medications and their potential as adjuvant therapeutics DOI Creative Commons
J. Liu, Joel Z. Nordin, Andrew J. McLachlan

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(8)

Published: Aug. 1, 2024

Pharmacokinetics (PK) and pharmacodynamics (PD) are central concepts to guide the dosage administration of drug therapies essential consider for both healthcare professionals researchers in therapeutic planning discovery. PK/PD properties a significantly influence variability response treatment, including failure or excessive medication-related harm. Furthermore, suboptimal PK constitute significant barrier further development some candidate treatments This article describes how extracellular vesicles (EVs) affect different aspects PD medications their potential modulate address problematic profiles drugs. We reviewed EVs' intrinsic effects on cell behaviours medication responses. also described surface cargo modifications can enhance EV functionalities enable them as adjuvants optimise profile conventional medications. we demonstrated that various bioengineering strategies be used modify EVs, hence enhancing

Language: Английский

Citations

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