Centralized brain networks underlie body part coordination during grooming DOI Creative Commons
Pembe Gizem Özdil, Jonathan Arreguit,

Camille Scherrer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Animals must coordinate multiple body parts to perform important tasks such as grooming, or locomotion. How this movement synchronization is achieved by the nervous system remains largely unknown. Here, we uncover neural basis of part coordination during goal-directed antennal grooming in fly, Drosophila melanogaster . We find that unilateral bilateral one both antenna, respectively, arises from synchronized movements head, antennae, and forelegs. Simulated replay these kinematics a biomechanical model shows makes more efficient permitting unobstructed, forceful collisions between foreleg tibiae antennae. Movements do not require proprioceptive sensory feedback others: neither amputation forelegs nor immobilization head prevented other unperturbed parts. By constructing comprehensive network fly brain connectome, centralized interneurons shared premotor neurons interconnect thus likely synchronize neck, antennal, motor networks. A simulated activation screen reveals cell classes required for grooming. These cells form two coupled circuit motifs enable robust synchronization: recurrent excitatory subnetwork promotes contralateral pitch broadcast inhibition suppresses ipsilateral pitch. Similarly controllers may flexible co-recruitment subserve variety behaviors.

Language: Английский

Neural circuit mechanisms for steering control in walkingDrosophila DOI Creative Commons

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: April 5, 2020

Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

72
Fine-grained descending control of steering in walking Drosophila DOI Creative Commons
Helen H. Yang,

Bella E. Brezovec,

Laia Serratosa Capdevila

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

13
Neural circuit mechanisms for steering control in walking Drosophila DOI Open Access

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

Published: Nov. 27, 2024

Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

13
Inhibitory control explains locomotor statistics in walking Drosophila DOI Creative Commons
Hannah Gattuso,

Karin A. van Hassel,

Jacob D. Freed

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(16)

Published: April 17, 2025

In order to forage for food, many animals regulate not only specific limb movements but the statistics of locomotor behavior, switching between long-range dispersal and local search depending on resource availability. How premotor circuits is clear. Here, we analyze model their modulation by attractive food odor in walking Drosophila . Food evokes three motor regimes flies: baseline walking, upwind running during odor, behavior following loss. During search, find that flies adopt higher angular velocities slower ground speeds turn longer periods same direction. We further different mean speed these state changes influence length odor-evoked runs. next developed a simple neural control suggests contralateral inhibition plays key role regulating statistical features locomotion. As fly connectome predicts decussating inhibitory neurons lateral accessory lobe (LAL), gained genetic access subset tested effects behavior. identified one population whose activation induces all signature regulates velocity at offset. second population, including single LAL neuron pair, bidirectionally speed. Together, our work develops biologically plausible computational architecture captures locomotion across behavioral states identifies substrates computations.

Language: Английский

Citations

0
Inhibitory control of locomotor statistics in walkingDrosophila DOI Creative Commons
Hannah Gattuso,

Karin A. van Hassel,

Jacob D. Freed

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

In order to forage for food, many animals regulate not only specific limb movements but the statistics of locomotor behavior over time, example switching between long-range dispersal behaviors and more localized search depending on availability resources. How pre-motor circuits such is clear. Here we took advantage robust changes in evoked by attractive odors walking

Language: Английский

Citations

3
Neural circuit mechanisms for steering control in walking Drosophila DOI Open Access

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

Published: Nov. 27, 2024

Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

0
Centralized brain networks underlie body part coordination during grooming DOI Creative Commons
Pembe Gizem Özdil, Jonathan Arreguit,

Camille Scherrer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Animals must coordinate multiple body parts to perform important tasks such as grooming, or locomotion. How this movement synchronization is achieved by the nervous system remains largely unknown. Here, we uncover neural basis of part coordination during goal-directed antennal grooming in fly, Drosophila melanogaster . We find that unilateral bilateral one both antenna, respectively, arises from synchronized movements head, antennae, and forelegs. Simulated replay these kinematics a biomechanical model shows makes more efficient permitting unobstructed, forceful collisions between foreleg tibiae antennae. Movements do not require proprioceptive sensory feedback others: neither amputation forelegs nor immobilization head prevented other unperturbed parts. By constructing comprehensive network fly brain connectome, centralized interneurons shared premotor neurons interconnect thus likely synchronize neck, antennal, motor networks. A simulated activation screen reveals cell classes required for grooming. These cells form two coupled circuit motifs enable robust synchronization: recurrent excitatory subnetwork promotes contralateral pitch broadcast inhibition suppresses ipsilateral pitch. Similarly controllers may flexible co-recruitment subserve variety behaviors.

Language: Английский

Citations

0