Biophysical Aspect of Assembly and Regulation of Nuclear Bodies Scaffolded by Architectural Rna DOI
Tetsuya Yamamoto, Tomohiro Yamazaki,

Kensuke Ninomiya

et al.

Published: Jan. 1, 2024

Language: Английский

Biophysical aspect of assembly and regulation of nuclear bodies scaffolded by architectural RNA DOI
Tetsuya Yamamoto, Tomohiro Yamazaki,

Kensuke Ninomiya

et al.

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: 437(9), P. 169016 - 169016

Published: Feb. 18, 2025

Language: Английский

Citations

1
RNA gradients can guide condensates toward promoters: implications for enhancer-promoter contacts and condensate-promoter kissing DOI Creative Commons

David Goh,

Deepti Kannan, Pradeep Natarajan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

We study how protein condensates respond to a site of active RNA transcription (i.e., gene promoter) due electrostatic protein-RNA interactions. Our results indicate that can show directed motion towards the promoter, driven by gradients in concentration. Analytical theory, consistent with simulations, predicts droplet velocity has non-monotonic dependence on distance promoter. explore consequences this gradient-sensing mechanism for enhancer-promoter (E-P) communication using polymer simulations intervening chromatin chain. Directed enhancer-bound can, together loop extrusion cohesin, collaboratively increase contact probability. Finally, we investigate under which conditions exhibit oscillations their morphology and Oscillatory dynamics are caused delayed response condensate-promoter negative feedback from accumulation at charge repulsion.

Language: Английский

Citations

0
Biophysical Aspect of Assembly and Regulation of Nuclear Bodies Scaffolded by Architectural Rna DOI
Tetsuya Yamamoto, Tomohiro Yamazaki,

Kensuke Ninomiya

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0