Synaptic, transcriptional and chromatin genes disrupted in autism

Nature, Journal Year: 2014, Volume and Issue: 515(7526), P. 209 - 215

Published: Oct. 29, 2014

Language: Английский

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Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

Cell, Journal Year: 2013, Volume and Issue: 155(5), P. 1008 - 1021

Published: Nov. 1, 2013

Language: Английский

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Metabolic regulation of gene expression through histone acylations

Nature Reviews Molecular Cell Biology, Journal Year: 2016, Volume and Issue: 18(2), P. 90 - 101

Published: Dec. 7, 2016

Language: Английский

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Advancing the understanding of autism disease mechanisms through genetics

Nature Medicine, Journal Year: 2016, Volume and Issue: 22(4), P. 345 - 361

Published: April 1, 2016

Language: Английский

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REST and stress resistance in ageing and Alzheimer’s disease

Nature, Journal Year: 2014, Volume and Issue: 507(7493), P. 448 - 454

Published: March 19, 2014

Language: Английский

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The genetic architecture of the human cerebral cortex

Science, Journal Year: 2020, Volume and Issue: 367(6484)

Published: March 19, 2020

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify variants affect structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed surface area and average thickness whole 34 regions with functional specializations. identified 199 significant found enrichment for influencing total within regulatory elements are active during prenatal development, supporting radial unit hypothesis. Loci regional cluster near genes in Wnt signaling pathways, which progenitor expansion areal identity. Variation structure genetically correlated function, Parkinson's disease, insomnia, depression, neuroticism, attention deficit hyperactivity disorder.

Language: Английский

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Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 330 - 348

Published: Oct. 1, 2018

Language: Английский

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Evidence for 28 genetic disorders discovered by combining healthcare and research data

Nature, Journal Year: 2020, Volume and Issue: 586(7831), P. 757 - 762

Published: Oct. 14, 2020

Language: Английский

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Looping Back to Leap Forward: Transcription Enters a New Era

Cell, Journal Year: 2014, Volume and Issue: 157(1), P. 13 - 25

Published: March 1, 2014

Language: Английский

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Genetics and Genomics of Congenital Heart Disease

Circulation Research, Journal Year: 2017, Volume and Issue: 120(6), P. 923 - 940

Published: March 16, 2017

Congenital heart disease is the most common birth defect, and because of major advances in medical surgical management, there are now more adults living with congenital (CHD) than children. Until recently, cause majority CHD was unknown. Advances genomic technologies have discovered genetic causes a significant fraction CHD, while at same time pointing to remarkable complexity genetics. This review will focus on evidence for underlying discuss data supporting both monogenic complex mechanisms CHD. The discoveries from studies draw attention biological pathways that simultaneously open door better understanding cardiac development affect clinical care patients Finally, we address evaluation families affected by

Language: Английский

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