Genomic imprinting: employing and avoiding epigenetic processes DOI Open Access
Marisa S. Bartolomei

Genes & Development, Journal Year: 2009, Volume and Issue: 23(18), P. 2124 - 2133

Published: Sept. 15, 2009

Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and results in a monoallelic, parental-specific expression pattern mammals. Few phenomena nature depend more on mechanisms while at the same time evading them. The of imprinted genes are marked epigenetically discrete elements termed control regions (ICRs) with their origin gametes through use DNA methylation, very least. Imprinted gene is subsequently maintained using noncoding RNAs, histone modifications, insulators, higher-order chromatin structure. Avoidance manifest when evade genome-wide reprogramming occurs after fertilization remain origin. This review summarizes what known about establishment maintenance marks discusses clusters. Additionally, evolution clusters described. While considerable information regarding has been obtained recently, much remains be learned.

Language: Английский

Unique features of long non-coding RNA biogenesis and function DOI
Jeffrey J. Quinn, Howard Y. Chang

Nature Reviews Genetics, Journal Year: 2015, Volume and Issue: 17(1), P. 47 - 62

Published: Dec. 15, 2015

Language: Английский

Citations

3272

Epigenetic Determinants of Cancer DOI Open Access
Stephen B. Baylin, Peter A. Jones

Cold Spring Harbor Perspectives in Biology, Journal Year: 2016, Volume and Issue: 8(9), P. a019505 - a019505

Published: May 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Language: Английский

Citations

1093

DNA Methylation in Mammals DOI Open Access

E. Li,

Yi Zhang

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(5), P. a019133 - a019133

Published: May 1, 2014

En Li1 and Yi Zhang2 1China Novartis Institutes for BioMedical Research, Pudong New Area, Shanghai 201203, China 2Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115 Correspondence: en.li{at}novartis.com

Language: Английский

Citations

843

Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator DOI Creative Commons
Roberto Bonasio, Qiye Li, Jinmin Lian

et al.

Current Biology, Journal Year: 2012, Volume and Issue: 22(19), P. 1755 - 1764

Published: Aug. 9, 2012

Language: Английский

Citations

393

Epigenetics across the human lifespan DOI Creative Commons

Riya R. Kanherkar,

Naina Bhatia‐Dey,

Antonei B. Csòka

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2014, Volume and Issue: 2

Published: Sept. 9, 2014

Epigenetics has the potential to explain various biological phenomena that have heretofore defied complete explication. This review describes types of endogenous human developmental milestones such as birth, puberty, and menopause, well diverse exogenous environmental factors influence health, in a chronological epigenetic context. We describe entire course life from periconception death chronologically note all internal timepoints external epigenome. Ultimately, environment presents these individual epigenome, unique genetic profile each also modulates specific response factors. During life, we are exposed an abounds with potent dynamic milieu capable triggering chemical changes activate or silence genes. There is constant interaction between environments required for normal development health maintenance influencing disease load resistance. For example, exposure pharmaceutical toxic chemicals, diet, stress, exercise, other eliciting positive negative modifications lasting effects on development, metabolism health. These can impact body so profoundly permanently alter individual. present comprehensive new hypothesis how cause both direct indirect this knowledge ultimately be used improve personalized medicine.

Language: Английский

Citations

380

Genomic imprinting disorders: lessons on how genome, epigenome and environment interact DOI
David Monk, Deborah Mackay, Thomas Eggermann

et al.

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(4), P. 235 - 248

Published: Jan. 15, 2019

Language: Английский

Citations

361

Epigenetics and Human Disease DOI Open Access
Huda Y. Zoghbi, Arthur L. Beaudet

Cold Spring Harbor Perspectives in Biology, Journal Year: 2016, Volume and Issue: 8(2), P. a019497 - a019497

Published: Feb. 1, 2016

Huda Y. Zoghbi1,2 and Arthur L. Beaudet2 1Howard Hughes Medical Institute, Baylor College of Medicine, Jan Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, 77030 2Department Molecular Human Genetics, Correspondence: hzoghbi{at}bcm.edu

Language: Английский

Citations

335

RNAi and Heterochromatin Assembly DOI Open Access
Robert A. Martienssen, Danesh Moazed

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(8), P. a019323 - a019323

Published: Aug. 1, 2015

Robert Martienssen1 and Danesh Moazed2 1Cold Spring Harbor Laboratory, Cold Harbor, New York 11724 2Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-5730 Correspondence: danesh{at}hms.harvard.edu

Language: Английский

Citations

280

Long-Range Chromatin Interactions DOI Open Access
Job Dekker, Tom Misteli

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(10), P. a019356 - a019356

Published: Oct. 1, 2015

Job Dekker1 and Tom Misteli2 1University of Massachusetts Medical School, Worcester, 01605 2National Cancer Institute, National Institutes Health, Bethesda, Maryland 20892 Correspondence: mistelit{at}mail.nih.gov

Language: Английский

Citations

261

Genomic Imprinting: A Mammalian Epigenetic Discovery Model DOI

Denise P. Barlow

Annual Review of Genetics, Journal Year: 2011, Volume and Issue: 45(1), P. 379 - 403

Published: March 2, 2011

Genomic imprinting is an epigenetic process leading to parental-specific expression of one two percent mammalian genes that offers the best model systems for a molecular analysis regulation in development and disease. In twenty years since first imprinted gene was identified, this has had significant impact on decoding information mammals. So far it led discovery long-range cis-acting control elements whose state regulates small clusters unusual macro noncoding RNAs (ncRNAs) directly repress cis, critically, demonstrated biological role DNA methylation allow normally repressed by default. This review describes progress understanding how protein-coding are silenced; particular, focuses ncRNAs have broad relevance as potential new layer regulatory genome.

Language: Английский

Citations

258