The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(8), P. 487 - 500

Published: June 27, 2016

Language: Английский

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The diverse roles of DNA methylation in mammalian development and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(10), P. 590 - 607

Published: Aug. 9, 2019

Language: Английский

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TET-mediated active DNA demethylation: mechanism, function and beyond

Nature Reviews Genetics, Journal Year: 2017, Volume and Issue: 18(9), P. 517 - 534

Published: May 30, 2017

Language: Английский

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Epigenetic Determinants of Cancer

Cold Spring Harbor Perspectives in Biology, Journal Year: 2016, Volume and Issue: 8(9), P. a019505 - a019505

Published: May 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Language: Английский

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Genomic Imprinting in Mammals

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(2), P. a018382 - a018382

Published: Feb. 1, 2014

Denise P. Barlow1 and Marisa S. Bartolomei2 1CeMM Research Center for Molecular Medicine of the Austrian Academy Sciences, CeMM, 1090 Vienna, Austria 2Department Cell Developmental Biology, University Pennsylvania Perelman School Medicine, Philadelphia, 19104-6148 Correspondence: dbarlow{at}cemm.oeaw.ac.at bartolom{at}mail.med.upenn.edu

Language: Английский

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Dynamics of epigenetic regulation at the single-cell level

Science, Journal Year: 2016, Volume and Issue: 351(6274), P. 720 - 724

Published: Feb. 12, 2016

Quantitative analysis of epigenetic memory To explore quantitative and dynamic properties transcriptional regulation by modifications, Bintu et al. monitored a reporter gene carried on human artificial chromosome in Chinese hamster ovary cells (see the Perspective Keung Khalil). They measured effects DNA methylation histone modifications or deacetylation single using time-lapse microscopy. Silencing was an all-or-none, stochastic event, so graded adjustments to transcription occurred from changes proportion that responded. Furthermore, duration recruitment chromatin regulators determined fraction were silenced. Thus, distinct modifiers can produce different characteristics memory. Science , this issue p. 720 ; see also 661

Language: Английский

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The ageing epigenome and its rejuvenation

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(3), P. 137 - 150

Published: Feb. 4, 2020

Language: Английский

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Epigenetic Regulation in Plants

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(12), P. a019315 - a019315

Published: Dec. 1, 2014

Craig S. Pikaard1 and Ortrun Mittelsten Scheid2 1Department of Biology, Department Molecular Cellular Biochemistry, Howard Hughes Medical Institute, Indiana University, Bloomington, 47405 2Gregor Mendel-Institute Plant Austrian Academy Sciences, 1030 Vienna, Austria Correspondence: ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at

Language: Английский

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Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution

Nature Biotechnology, Journal Year: 2019, Volume and Issue: 37(4), P. 424 - 429

Published: Feb. 25, 2019

Language: Английский

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A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

Genome biology, Journal Year: 2018, Volume and Issue: 19(1)

Published: Dec. 1, 2018

Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as oncogenic driver in hematological malignancies and promotes tumor growth solid tumors. However, little is known about the mechanisms underlying activation of this proto-oncogene Immunohistochemical staining showed that FLI1 aberrantly overexpressed advanced stage metastatic breast cancers. Using a CRISPR Cas9-guided immunoprecipitation assay, we identify circular RNA promoter chromatin complex, consisting exons 4-2-3, referred to FECR1.Overexpression FECR1 enhances invasiveness MDA-MB231 cancer cells. Notably, utilizes positive feedback mechanism activate by inducing DNA hypomethylation CpG islands promoter. binds cis recruits TET1, demethylase actively involved demethylation. also downregulates trans DNMT1, methyltransferase essential for maintenance methylation. These data suggest upstream regulator control coordinating regulation methylating demethylating enzymes. Thus, drives metastasis not only through canonical oncoprotein pathway, but using epigenetic mediated its exonic RNA.

Language: Английский

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