Drosophila as a model for ageing

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2017, Volume and Issue: 1864(9), P. 2707 - 2717

Published: Sept. 29, 2017

Language: Английский

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The complex role of adipokines in obesity, inflammation, and autoimmunity

Clinical Science, Journal Year: 2021, Volume and Issue: 135(6), P. 731 - 752

Published: March 1, 2021

Abstract The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since discovery of leptin 1994, multitude studies have characterized pathological changes that occur within adipose tissue obese state. One significant change dysregulation adipokine production. Adipokines are an indispensable link between metabolism optimal immune system function; however, their contributes low-grade inflammation pathology. Herein, I will highlight current knowledge on structure physiological function, focus known roles these factors modulation response. also discuss adipokines rheumatic autoimmune diseases.

Language: Английский

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Regulation of Body Size and Growth Control

Genetics, Journal Year: 2020, Volume and Issue: 216(2), P. 269 - 313

Published: Oct. 1, 2020

Abstract The control of body and organ growth is essential for the development adults with proper size proportions, which important survival reproduction. In animals, adult determined by rate duration juvenile growth, are influenced environment. nutrient-scarce environments in more time needed period can be extended delaying maturation, whereas rapidly completed nutrient-rich conditions. This flexibility requires integration environmental cues developmental signals that govern internal checkpoints to ensure maturation does not begin until sufficient tissue has occurred reach a size. Target Rapamycin (TOR) pathway primary cell-autonomous nutrient sensor, while circulating hormones such as steroids insulin-like factors main systemic regulators animals. We discuss recent findings Drosophila melanogaster showing environment growth-sensing mechanisms, involving TOR other growth-regulatory pathways, converge on insulin steroid relay centers responsible adjusting development, response external addition this, also monitored coordinated whole-body timing through modulation signaling. coordination involves interorgan communication mediated peptide 8 status. Together, these multiple nutritional feed into neuroendocrine hubs controlling signaling, serving at progression toward delayed. review focuses mechanisms conditions modulate size, highlights conserved architecture this system, made prime model understanding

Language: Английский

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Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(3), P. 522 - 534

Published: March 1, 2017

Language: Английский

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Metabolism and growth adaptation to environmental conditions in Drosophila

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 77(22), P. 4523 - 4551

Published: May 24, 2020

Organisms adapt to changing environments by adjusting their development, metabolism, and behavior improve chances of survival reproduction. To achieve such flexibility, organisms must be able sense respond changes in external environmental conditions internal state. Metabolic adaptation response altered nutrient availability is key maintaining energy homeostasis sustaining developmental growth. Furthermore, variables exert major influences on growth final adult body size animals. This plasticity depends adaptive responses state cues that are essential for processes. Genetic studies have shown the fruit fly Drosophila, similarly mammals, regulates its growth, environment through several hormones including insulin, peptides with glucagon-like function, steroid hormones. Here we review emerging evidence showing various sensed different organs that, via inter-organ communication, relay information neuroendocrine centers control insulin signaling. focuses endocrine regulation highlighting recent advances role system as a signaling hub integrates inputs drives responses.

Language: Английский

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Roles of the insulin signaling pathway in insect development and organ growth

Peptides, Journal Year: 2018, Volume and Issue: 122, P. 169923 - 169923

Published: Feb. 16, 2018

Language: Английский

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A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition

Developmental Cell, Journal Year: 2018, Volume and Issue: 46(4), P. 456 - 469.e4

Published: Aug. 1, 2018

Language: Английский

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The Lysosome at the Intersection of Cellular Growth and Destruction

Developmental Cell, Journal Year: 2020, Volume and Issue: 54(2), P. 226 - 238

Published: June 30, 2020

Language: Английский

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Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms

Science China Life Sciences, Journal Year: 2021, Volume and Issue: 64(8), P. 1236 - 1280

Published: April 22, 2021

Language: Английский

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Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti

Proceedings of the National Academy of Sciences, Journal Year: 2018, Volume and Issue: 115(42)

Published: Oct. 1, 2018

Significance Mosquitoes pose an enormous threat to humans by transmitting numerous dangerous diseases. To become reproductively competent and effective disease vectors, it is crucial for them achieve optimal body size nutritional status. Elucidation of these processes in mosquitoes has been hampered the lack classic genetics tools. CRISPR-Cas9 disruption fat-body–specific serotonin receptor Aa5HT2B impairs growth lipid accumulation Aedes aegypti mosquitoes, vectors dengue fever, yellow Zika virus. controls insulin-like peptides. Using approach, we have uncovered differential roles peptides control metabolism, provided a link between blood feeding signaling.

Language: Английский

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