Hallmarks of Cancer: New Dimensions

Cancer Discovery, Journal Year: 2022, Volume and Issue: 12(1), P. 31 - 46

Published: Jan. 1, 2022

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity phenotypes and genotypes into provisional set underlying principles. As knowledge mechanisms has progressed, other facets disease have emerged as potential refinements. Herein, prospect raised that phenotypic plasticity disrupted differentiation discrete hallmark capability, nonmutational epigenetic reprogramming polymorphic microbiomes both constitute distinctive enabling characteristics facilitate acquisition capabilities. Additionally, senescent cells, varying origins, may be added to roster functionally important cell types in tumor microenvironment. SIGNIFICANCE: Cancer daunting breadth scope its diversity, spanning genetics, tissue biology, pathology, response therapy. Ever more powerful experimental computational tools technologies are providing an avalanche "big data" about myriad manifestations diseases encompasses. integrative concept embodied helping distill this increasingly logical science, new dimensions presented perspective add value endeavor, fully understand development malignant progression, apply medicine.

Language: Английский

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The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(8), P. 487 - 500

Published: June 27, 2016

Language: Английский

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Epigenetic Determinants of Cancer

Cold Spring Harbor Perspectives in Biology, Journal Year: 2016, Volume and Issue: 8(9), P. a019505 - a019505

Published: May 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Language: Английский

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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Dec. 17, 2019

Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. dysregulation is often linked to human disease, notably cancer. With development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied treatment hematological malignancies and exhibited viable therapeutic potential for solid tumors preclinical clinical trials. In this review, we summarize aberrant functions enzymes methylation, acetylation methylation during tumor progression highlight inhibitors targeted at enzymes.

Language: Английский

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Genetics and biology of prostate cancer

Genes & Development, Journal Year: 2018, Volume and Issue: 32(17-18), P. 1105 - 1140

Published: Sept. 1, 2018

Despite the high long-term survival in localized prostate cancer, metastatic cancer remains largely incurable even after intensive multimodal therapy. The lethality of advanced disease is driven by lack therapeutic regimens capable generating durable responses setting extreme tumor heterogeneity on genetic and cell biological levels. Here, we review available model systems, genome atlas, cellular functional microenvironment, tumor-intrinsic tumor-extrinsic mechanisms underlying resistance, technological advances focused detection management. These advances, along with an improved understanding adaptive to conventional therapies, anti-androgen therapy, immunotherapy, are catalyzing development more effective strategies for disease. In particular, knowledge heterotypic interactions between coevolution host cells microenvironment has illuminated novel combinations a strong potential eventual cures Improved management will also benefit from artificial intelligence-based expert decision support systems proper standard care, prognostic determinant biomarkers minimize overtreatment disease, new standards care accelerated next-generation clinical trials.

Language: Английский

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Epigenetics of colorectal cancer: biomarker and therapeutic potential

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 17(2), P. 111 - 130

Published: Jan. 3, 2020

Language: Английский

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Epigenetic modifications of histones in cancer

Genome biology, Journal Year: 2019, Volume and Issue: 20(1)

Published: Nov. 20, 2019

Abstract The epigenetic modifications of histones are versatile marks that intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types histone biological processes with which they involved. Specifically, review enzymatic machineries involved in cancer progression, how apply currently available small molecule inhibitors for modifiers as tool compounds study functional significance their clinical implications.

Language: Английский

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Evolving therapeutic landscape of advanced hepatocellular carcinoma

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(4), P. 203 - 222

Published: Nov. 11, 2022

Language: Английский

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Metabolic reprogramming and epigenetic modifications on the path to cancer

Protein & Cell, Journal Year: 2021, Volume and Issue: 13(12), P. 877 - 919

Published: May 29, 2021

Abstract Metabolic rewiring and epigenetic remodeling, which are closely linked reciprocally regulate each other, among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes a consequence translocation spatial regionalization metabolites. Various metabolic alterations modifications also reportedly drive immune escape impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how reprogramming cells reshapes alterations, particular acetylation methylation histone proteins DNA. We discuss other eminent such as, succinylation, hydroxybutyrylation, lactylation, update current advances metabolism- modification-based therapeutic prospects cancer.

Language: Английский

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The Need for Multi-Omics Biomarker Signatures in Precision Medicine

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4781 - 4781

Published: Sept. 26, 2019

Recent advances in omics technologies have led to unprecedented efforts characterizing the molecular changes that underlie development and progression of a wide array complex human diseases, including cancer. As result, multi-omics analyses—which take advantage these genomics, transcriptomics, epigenomics, proteomics, metabolomics, other areas—have been proposed heralded as key advancing precision medicine clinic. In field oncology, genomics approaches, and, more recently, analyses helped reveal several mechanisms cancer development, treatment resistance, recurrence risk, findings implemented clinical oncology help guide decisions. However, truly integrated not applied widely, preventing further medicine. Additional are needed develop analytical infrastructure necessary generate, analyze, annotate data effectively inform medicine-based decision-making.

Language: Английский

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