Circulating tumor cell-derived preclinical models: current status and future perspectives DOI Creative Commons
Zuzana Kahounová,

Markéta Pícková,

Stanislav Drápela

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(8)

Published: Aug. 17, 2023

Abstract Despite the advancements made in diagnosis and treatment of cancer, stages associated with metastasis remain largely incurable represent primary cause cancer-related deaths. The dissemination cancer is facilitated by circulating tumor cells (CTCs), which originate from or metastatic sites enter bloodstream, subsequently spreading to distant parts body. CTCs have garnered significant attention research due their accessibility peripheral blood, despite low abundance. They are being extensively studied gain a deeper understanding mechanisms underlying identify effective therapeutic strategies for advanced disease. Therefore, substantial efforts been directed towards establishing characterizing relevant experimental models derived CTCs, aiming provide tools research. In this review, we an overview recent progress establishment preclinical CTC-derived models, such as xenografts (CDX) cell cultures, show promise study CTCs. We discuss advantages limitations these conclude summarizing potential future use decisions utility precision medicine tools.

Language: Английский

TGFβ biology in cancer progression and immunotherapy DOI
Rik Derynck, Shannon J. Turley, Rosemary J. Akhurst

et al.

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 18(1), P. 9 - 34

Published: July 24, 2020

Language: Английский

Citations

649
Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers DOI Open Access
Hà Thị Thu, Chang Hoon Lee,

Jungsook Cho

et al.

Cancers, Journal Year: 2020, Volume and Issue: 12(2), P. 287 - 287

Published: Jan. 24, 2020

Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid tissue development. Recent advances have indicated chemokines their cognate receptors play critical roles in cancer-related inflammation cancer progression. On the basis of these findings, chemokine system has become a new potential drug target for immunotherapy. In this review, we summarize essential complex network Furthermore, discuss value as prognostic marker. The regulates infiltration cells into tumor microenvironment, which induces both pro- anti-immunity promotes or suppresses growth proliferation, angiogenesis, metastasis. Increasing evidence indicates promising patients. While CCL2, CXCL10, CX3CL1/CX3CR1 can serve favorable unfavorable factors depending on types, CCL14 XCL1 possess good value. Other such CXCL1, CXCL8, CXCL12 poor markers. Despite vast our understanding nature biology, knowledge about multifaceted different types cancers is still limited. Further studies necessary to decipher distinct within terms progression validate prognosis.

Language: Английский

Citations

189
Cancer Stem Cell Plasticity – A Deadly Deal DOI Creative Commons

Archana P. Thankamony,

Kritika Saxena,

Reshma Murali

et al.

Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7

Published: April 30, 2020

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting of cancer. Accumulating evidence suggests that fraction cells within tumor termed Cancer Stem Cells (CSCs) are primarily responsible for this diversity resulting resistance and metastasis. Adding to complexity, recent studies have shown there can be different subpopulations CSCs with varying biochemical biophysical traits varied dissemination drug-resistance potential. Moreover, cancer exhibit high level plasticity or ability dynamically switch between CSC non-CSC statesoramong subsets CSCs. The molecular mechanisms underlying such has been under extensive investigation trans-differentiation process Epithelial Mesenchymal transition (EMT) identified as contributing factor. Besides genetic epigenetic factors, also shaped by non-cell-autonomous effects microenvironment. In review, we discuss developments understanding progression at levels,and latest silico approaches being taken characterizing cell implications improving existing approaches.

Language: Английский

Citations

139
Tumor-associated macrophages: an effective player of the tumor microenvironment DOI Creative Commons
Udit Basak, Tania Sarkar, Sumon Mukherjee

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 16, 2023

Cancer progression is primarily caused by interactions between transformed cells and the components of tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up majority invading immune components, which are further categorized as anti-tumor M1 pro-tumor M2 subtypes. While known to have anti-cancer properties, recognized extend a protective role tumor. As result, manipulates TME in such way that it induces macrophage infiltration switching bias secure its survival. This M2-TAM promotes cancer cell proliferation, neoangiogenesis, lymphangiogenesis, epithelial-to-mesenchymal transition, matrix remodeling for metastatic support, manipulation an immunosuppressive state. additionally promote emergence stem (CSCs), their ability originate, metastasize, relapse into tumors. CSCs also help revealing escape survival strategies during initiation phases. review describes reasons immunotherapy failure and, thereby, devises better impair tumor-TAM crosstalk. study will shed light on understudied TAM-mediated address much-needed holistic approach therapy, encompasses targeting cells, CSCs, all at same time.

Language: Английский

Citations

95
Tumor-associated macrophages promote epithelial–mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling DOI Creative Commons

Xiangzhou Chen,

Mingqiang Yang,

Jiang Yin

et al.

Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)

Published: June 17, 2022

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of with poor prognosis and limited treatment. As major component the tumor microenvironment, tumor-associated macrophages (TAMs) play an important role in facilitating behavior TNBC. This study aimed to explore novel mechanism TAMs regulation epithelial-mesenchymal transition (EMT) stem cell (CSC) properties TNBC.Expression M2-like macrophage marker CD163 was evaluated by immunohistochemistry human tissues. The phenotype M2 polarized from Tohoku-Hospital-Pediatrics-1 (THP1) cells verified flow cytometry. Transwell assays, wound healing western blotting, cytometry, ELISA, quantitative polymerase chain reaction (qPCR), luciferase reporter gene immunofluorescence assays were conducted investigate which regulate EMT CSC BT549 HCC1937 cells.Clinically, we observed high infiltration TNBC tissues confirmed that associated unfavorable patients. Moreover, found conditioned medium (M2-CM) markedly promoted cells. Mechanistically, demonstrated chemokine (C-C motif) ligand 2 (CCL2) secretion activated Akt signaling, turn increased expression nuclear localization β-catenin. Furthermore, β-catenin knockdown reversed TAM-induced properties.This provides promote enhance via activation CCL2/AKT/β-catenin may offer new strategies for diagnosis treatment Video Abstract.

Language: Английский

Citations

85
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance DOI Creative Commons
Gh. Rasool Bhat,

Itty Sethi,

Hana Q. Sadida

et al.

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 197 - 228

Published: Feb. 8, 2024

Abstract Cancer is a complex disease displaying variety of cell states and phenotypes. This diversity, known as cancer plasticity, confers cells the ability to change in response their environment, leading increased tumor diversity drug resistance. review explores intricate landscape offering deep dive into cellular, molecular, genetic mechanisms that underlie this phenomenon. plasticity intertwined with processes such epithelial-mesenchymal transition acquisition stem cell–like features. These are pivotal development progression tumors, contributing multifaceted nature challenges associated its treatment. Despite significant advancements targeted therapies, adaptability subsequent therapy-induced resistance remain persistent obstacles achieving consistent, successful treatment outcomes. Our delves array exploit maintain including epigenetic modifications, alterations signaling pathways, environmental interactions. We discuss strategies counteract targeting specific cellular pathways employing combination therapies. promise enhance efficacy treatments mitigate therapy In conclusion, offers holistic, detailed exploration aiming bolster understanding approach toward tackling posed by heterogeneity As articulated review, delineation underlying seeks contribute substantially progress therapeutics advancement precision medicine, ultimately enhancing prospects for effective patient

Language: Английский

Citations

58
Cancer Stem Cells as a Potential Target to Overcome Multidrug Resistance DOI Creative Commons

Yena Cho,

Yong Kee Kim

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: June 2, 2020

Multidrug resistance (MDR), which is a significant impediment to the success of cancer chemotherapy, attributable various defensive mechanisms in cancer. Initially, overexpression ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp) was considered most important mechanism for drug resistance; hence, many investigators long time focused on development specific ABC transporter inhibitors. However, date their efforts have failed develop clinically applicable drug, leaving only number problems. The concept stem cells (CSCs) has provided new directions both and MDR research. known be one features CSCs thus plays crucial role recurrence exacerbation. Therefore, recent years, research targeting been increasing rapidly search an effective treatment. Here, we review drugs that studied developed overcome CSCs, discuss limitations future perspectives.

Language: Английский

Citations

93
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response DOI Open Access
Michelle von Locquenghien,

Catalina Rozalén,

Toni Celià-Terrassa

et al.

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(1)

Published: Jan. 3, 2021

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions and immune system regulation. In cancer, IFNs contribute to tumor-intrinsic -extrinsic mechanisms that determine the quality antitumor immunity response immunotherapy. this Review, we focus on different types tumor IFN sensitivity dynamic tumor-immune interactions their coevolution during cancer progression metastasis. We extend discussion new evidence supporting immunotherapy-mediated immunoediting dual opposing roles lead checkpoint blockade or resistance. Understanding intricate responses will novel immunotherapeutic strategies circumvent protumorigenic effects while exploiting IFN-mediated immunity.

Language: Английский

Citations

92
Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma DOI
Rama Krishna Nimmakayala,

Frank Leon,

Satyanarayana Rachagani

et al.

Oncogene, Journal Year: 2020, Volume and Issue: 40(1), P. 215 - 231

Published: Oct. 27, 2020

Language: Английский

Citations

88
Emerging Role of E2F Family in Cancer Stem Cells DOI Creative Commons
Dan Xie, Pei Qin, Jingyuan Li

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Aug. 12, 2021

The E2F family of transcription factors (E2Fs) consist eight genes in mammals. These encode ten proteins that are usually classified as transcriptional activators or repressors. E2Fs important for many cellular processes, from their canonical role cell cycle regulation to other roles angiogenesis, the DNA damage response and apoptosis. A growing body evidence demonstrates cancer stem cells (CSCs) key players tumor development, metastasis, drug resistance recurrence. This review focuses on CSCs notes signals can regulate activities E2Fs, which turn transcriptionally different targets contribute various biological characteristics CSCs, such proliferation, self-renewal, resistance. Therefore, may be promising biomarkers therapeutic associated with pathologies. Finally, exploring strategies result disruption prevent growth,

Language: Английский

Citations

71