Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111535 - 111535
Published: April 1, 2025
Language: Английский
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 13, 2024
Magnesium (Mg), an essential mineral abundantly present within the human body, is intricately involved in a multitude of biochemical processes vital for maintaining health and overall well-being. This review aims to delve into multifaceted impact Mg on health, exploring its physiological functions, dietary sources, potential implications deficiency or insufficiency. plays pivotal role various processes, including energy metabolism, muscle contraction, protein synthesis, DNA synthesis. It acts as cofactor more than 300 enzymatic reactions, facilitating conversion adenosine triphosphate (ATP) diphosphate (ADP) production. Moreover, proper functioning ion channels, particularly calcium influencing nerve transmission relaxation. naturally found wide array foods, with green leafy vegetables, whole grains, nuts, seeds, legumes being rich sources. Additionally, certain fortified foods supplements provide supplemental intake. Deficiency insufficiency mg can have profound health. Inadequate levels been associated increased risks chronic diseases, hypertension, type 2 diabetes, osteoporosis, cardiovascular diseases. Furthermore, may manifest symptoms such weakness, fatigue, tremors, irregular heartbeat. Numerous studies elucidated relationship between intake risk developing For instance, epidemiological evidence suggests that higher reduced possibly due vasodilatory effects influence blood pressure regulation mechanisms. Similarly, has implicated pathophysiology contributing insulin resistance impaired glucose metabolism. adequate crucial bone density reducing mineralization Understanding importance physiology underscores significance ensuring through diet supplementation. Healthcare professionals play critical educating individuals about incorporating mg-rich their diets considering supplementation when necessary, at those indispensable far-reaching Its involvement Ensuring preventing deficiency-related complications Further research warranted elucidate optimal strategies therapeutic applications disease prevention management.
Language: Английский
Citations
9
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: Feb. 7, 2025
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 22, 2025
Neutrophils play a critical role in the cancer-immunity cycle and are associated with poor clinical outcomes. Recent research has primarily focused on targeted delivery, phenotypic reversal, reprogramming of tumor-associated neutrophils, while impact disease-associated neutrophils (DANs) antitumor therapy remains understudied. Since liposomes, as drug delivery carriers, possess excellent biocompatibility stability, making them particularly suitable for combination therapy, we optimized formulation asymmetrically branched polyethylene glycol-modified mitomycin C lipid prodrug liposomes (PEG2,5 K@MLP-L) prepared hyaluronic acid sialic ester stearate-co-modified dexamethasone palmitate (HA*SAS@DXP-L) to study DANs normal, obese, aged, septic mice. An increase mitochondria lysosomes Ly-6G+CXCR2high accelerated clearance, reduced CD3+CD8+ T cell activity tumor-draining lymph nodes, decreased CD8+ infiltration tumors. As proportion increased, efficacy PEG2,5 K@MLP-L decreased. Combination HA*SAS@DXP-L can reshape DANs, promote cycle, enhance treatment efficacy. This identifies key characteristics functions presents promising strategy improving
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141625 - 141625
Published: March 1, 2025
Language: Английский
Citations
1
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 701 - 701
Published: March 12, 2025
Background/Objectives: Intestinal dysbiosis and systemic inflammation are involved in the pathophysiology of obesity its complications. Presepsin is a recently discovered marker, being soluble form bacterial lipopolysaccharide (LPS) receptor. Due to imbalance gut flora subsequent disruption intestinal barrier, circulating LPS levels have been found be elevated patients with metabolic diseases, even absence infection. However, date, no studies evaluated whether associated presepsin levels. Methods: The present study included 81 participants (61.7% women, 27 obesity, 34 overweight, 20 controls normal body mass index), all free infection diabetes mellitus. was measured serum by ELISA, concentrations were compared between groups. Results: group had higher (8.09 vs. 4.45 ng/mL, p = 0.06). When history cardiovascular disease excluded from analysis adjusting for multiple confounders through regression model, values than overweight control groups (5.84 3.32 0.016). In contrast, lower both (p 0.005) 0.031). We did not find an association 25-hydroxy vitamin D 0.368). Conclusions: Although cross-sectional character cannot demonstrate causal relationships, results could potentially suggest that implicated pathogenesis barrier. findings should only seen as hypothesis-generating. reduction state interesting finding deserves further investigation.
Language: Английский
Citations
1
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 8, 2025
The relationship between sugar-sweetened beverage (SSB) intake and phenotypic age acceleration (PhenoAgeAccel) is unclear. aim of this study was to explore the associations energy timing SSB PhenoAgeAccel in adults. A cross-sectional analysis conducted using data from National Health Nutrition Examination Survey (NHANES) 2007–2010, which involved U.S. adults aged 20 79 years. assessment estimation were through 24-hour dietary recall interviews, categorizing participants into three groups: non-intake, low moderate-intake, moderate–high-intake. Furthermore, consumers divided time intervals based on timing: dawn-to-forenoon (5:00 a.m. 11:59 a.m.), noon-to-afternoon (12:00 p.m. 17:59 p.m.), dusk-to-night (18:00 4:59 a.m.). Multivariable linear regression models employed evaluate (energy timing) PhenoAgeAccel. Additionally, stratified analyses interaction conducted. obesity assessed via two distinct metrics: body roundness index (BRI) mass (BMI). Mediation investigate mediating effect After controlling for covariates, (per 100 kcal/day) positively correlated with (β = 0.179, 95% confidence interval [CI]: 0.086–0.271). moderate–high-intake group presented a significantly greater than non-intake 1.023, CI: 0.414–1.632). This remained stable across analyses. Compared those who abstained SSB, consumed during period exhibited notably elevated 0.915, 0.316–1.514). significant interactive smoking timing–PhenoAgeAccel association observed (P 0.002). revealed that both BRI BMI mediated PhenoAgeAccel, mediation proportions 16.29% 16.21%, respectively. Our positive correlation may be partially by obesity. Moreover, consuming increase
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 161 - 161
Published: Jan. 10, 2025
The functionality of redox metabolism is frequently named as an important contributor to the processes aging and anti-aging. Excessive activation free radical reactions accompanied by inability antioxidant defense (AOD) mechanisms control flow reactive oxygen species (ROS) leads persistence oxidative stress, hypoxia, impaired mitochondrial energy function reduced ATP potential. From a long-term perspective, such changes contribute development chronic diseases facilitate aging. In turn, preconditioning biosystem with small doses stressful stimuli might cause mobilization AOD excessive ROS, which supports optimal functioning reactions. Those are crucial importance for anti-aging also known eustress or hormetic response. To ensure continuous support mild pro-oxidant activity in metabolic system, close monitoring timely corrections preventing ROS production required. paper introduces potential heart rate variability (HRV) biomarker functional reserves tool measure stress resilience during practical approaches interpretation HRV provided based on total power, power response orthostatic test activities all spectral components. It suggested that complex those parameters can reflect depth may be used guide lifestyle interventions promote active longevity.
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 16, 2025
Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing global health burden. Systemic inflammation phenotypic ageing have been respectively reported to associate with certain CRD. However, little known about the co-exposures mutual associations Here, we aim systematically elucidate joint mediating systemic immune-inflammation index (SII) age acceleration (PhenoAgeAccel) CRD based on data from National Health Nutrition Examination Survey (NHANES). Data for this study was obtained NHANES 2007-2010 2015-2018. The single combined SII PhenoAgeAccel were analyzed using multivariable logistic regression models. dose-response relationship between exposures outcomes determined by restricted cubic splines (RCS) regression. Subgroup mediation analyses further conducted. Totally, 15,075 participants enrolled in including 3,587 patients. Compare controls, patients tended be older, females present higher values. Single-index analysis indicated that either or demonstrated significantly positive association via regressions RCS curves. Furthermore, joint-indexes revealed compared individuals lower PhenoAgeAccel, those exhibited remarkably stronger (adjusted OR [aOR], 1.56; 95% CI, 1.31-1.85; P < 0.001), chronic obstructive pulmonary disease (aOR, 1.22-2.00; = 0.001) asthma 1.40; 1.16-1.70; which predominant among aged above 40 years, smokers. Eventually, suggested effects mediated resulting more significantly. This confirmed coexposure effect We recommend assessment may conduce accurate identification populations susceptible early prevention diseases.
Language: Английский
Citations
0
Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 20, 2025
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 92 - 92
Published: Jan. 18, 2025
This proposed review aims to shed light on the major genetic and epigenetic contributions ageing process longevity of individuals. In this context, we summarize state knowledge most important variants, their interactions with environment, in achieving a healthy lifespan. We also explore contribution lifestyle influence non-heritable environmental factors (i.e., epigenetics). Accordingly, discuss role inflammageing as one targets overcome morbidity mortality older people for maintenance ageing. more integrated view will display not only underlying mechanisms at play but invites reader rethink both our attitudes toward age.
Language: Английский
Citations
0