Oligodendrocytes, the Forgotten Target of Gene Therapy DOI Creative Commons
Yasemin Güneş, Catherine Le Stunff, Pierre Bougnères

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1973 - 1973

Published: Nov. 28, 2024

If the billions of oligodendrocytes (OLs) populating central nervous system (CNS) patients could express their feelings, they would undoubtedly tell gene therapists about frustration with other neural cell populations, neurons, microglia, or astrocytes, which have been favorite targets transfer experiments. This review questions why OLs left out most therapy attempts. The first explanation is that pathogenic role still discussed in CNS diseases. Another reason so-called ubiquitous CAG, CBA, CBh, CMV promoters—widely used studies—are unable poorly able to activate transcription episomal transgene copies brought by adeno-associated virus (AAV) vectors OLs. Accordingly, expression has either not found evaluated studies rodents non-human primates. aims current are give rightful place among cells future target and encourage researchers test effect OL transduction various

Language: Английский

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes DOI Creative Commons
Jenea M. Bin, Katie Emberley, Tobias J. Buscham

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

SUMMARY Myelination facilitates the rapid conduction of action potentials along axons. In central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with speed scaling linearly increasing diameter. Axon diameter and myelination are closely interlinked, axon exerting a strong influence on myelination. Conversely, myelinating Schwann cells peripheral can both positively negatively affect However, whether is regulated by CNS oligodendrocytes less clear. Here, we investigated growth absence myelin using mouse ( Mbp shi/shi M yrf conditional knockout) zebrafish olig2 morpholino) models. We find that neither ensheathment axons, nor formation compact required for to achieve appropriate diverse diameters. This indicates developmental independent myelination, shows PNS differentially axonal morphology.

Language: Английский

Citations

1
Oligodendrocytes and myelin in aging and disease DOI Creative Commons
Ana Fernández–Sainz, Rocío Rojas, Asier Ruiz

et al.

Ageing & Longevity, Journal Year: 2025, Volume and Issue: 1.2025, P. 46 - 53

Published: Feb. 11, 2025

Oligodendrocytes, the myelinating cells of central nervous system, insulate axons with myelin, enabling rapid signal transmission, supporting neuronal metabolism, and contributing to brain plasticity. However, aging neurodegenerative diseases can significantly impair oligodendrocyte function myelin integrity. During aging, progenitor (OPCs) exhibit a reduced regenerative capacity, leading progressive deterioration cognitive decline. In Alzheimer’s disease, these age-related deficits are exacerbated by neuroinflammation, oxidative stress, amyloid-beta (Aβ) tau pathology, which collectively survival remyelination capacity. Similarly, in Parkinson’s α-synuclein aggregation contributes decline through both shared disease-specific mechanisms. Here, we highlight key features aged diseased oligodendrocytes emphasizing their roles energy plasticity, resilience. Understanding aspects is essential for developing strategies counteract promote neuroprotection diseases.

Language: Английский

Citations

1
Regulators of Oligodendrocyte Differentiation DOI
Ben Emery, Teresa L. Wood

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(6), P. a041358 - a041358

Published: March 19, 2024

Ben Emery1 and Teresa L. Wood2 1Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, 97239, USA 2Department Pharmacology, Physiology Neuroscience, New Jersey Medical School, Rutgers Newark, 07103, Correspondence: terri.wood{at}rutgers.edu

Language: Английский

Citations

7
White matter aging and its impact on brain function DOI Creative Commons
Janos Groh, Mikael Simons

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase matter hyperintensities. These changes are closely linked to cognitive decline neurological disabilities. The deterioration myelin its diminished ability regenerate as we age further contribute the progression neurodegenerative disorders. Understanding these is crucial for devising effective disease prevention strategies. Here, will discuss alterations that occur with aging examine cellular molecular mechanisms driving aging-related transformations. We highlight how progressive disruption may initiate self-perpetuating cycle inflammation neural damage.

Language: Английский

Citations

7
The gut microbiota–oligodendrocyte axis: A promising pathway for modulating oligodendrocyte homeostasis and demyelination-associated disorders DOI Creative Commons
Wen Tang, Qi Wang,

Mingguang Sun

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122952 - 122952

Published: Aug. 9, 2024

The bidirectional regulation between the gut microbiota and brain, known as gut-brain axis, has received significant attention. myelin sheath, produced by oligodendrocytes or Schwann cells, is essential for efficient nervous signal transmission maintenance of brain function. Growing evidence shows that both oligodendrogenesis myelination are modulated its metabolites, when dysbiosis occurs, changes in composition and/or associated metabolites may impact developmental occurrence neurodevelopmental disabilities. Although link demyelinating disease such multiple sclerosis been extensively studied, our knowledge about role other myelin-related disorders, neurodegenerative diseases, limited. Mechanistically, microbiota-oligodendrocyte axis primarily mediated factors inflammation, vagus nerve, endocrine hormones, evidenced metagenomics, metabolomics, vagotomy, morphological molecular approaches. Treatments targeting this include probiotics, prebiotics, microbial herbal bioactive compounds, specific dietary management. In addition to commonly used approaches, viral vector-mediated tracing gene manipulation, integrated multiomics multicenter clinical trials will greatly promote mechanistic interventional studies ultimately, development new preventive therapeutic strategies against gut-oligodendrocyte axis-mediated impairments. Interestingly, recent findings showed can be induced hippocampal damage reversible myelin-targeted drugs, which provides insights into understanding how hippocampus-based functional impairment (such Alzheimer's disease) regulates peripheral homeostasis systemic disorders.

Language: Английский

Citations

4
The Pericellular Function of Fibulin-7 in the Adhesion of Oligodendrocyte Lineage Cells to Neuronal Axons during CNS Myelination DOI

Momona Yamada,

Binri Sasaki,

Nanako Yamada

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 748, P. 151271 - 151271

Published: Jan. 2, 2025

Language: Английский

Citations

0
Electroacupuncture promotes oligodendrocyte differentiation and myelin repair in a rat model of vascular dementia: Investigation of the mechanism from NF-κB-mediated inflammation DOI
Chang Liu, Huayi Yin, Xiaoyu Chen

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The Exciting Frontier of Neuroplasticity: Innovations in Brain Health and Recovery DOI Open Access
Ramendra N. Saha

Journal of Behavioral and Brain Science, Journal Year: 2025, Volume and Issue: 15(03), P. 47 - 80

Published: Jan. 1, 2025

Language: Английский

Citations

0
Paroxetine ameliorates corticosterone-induced myelin damage by promoting the proliferation and differentiation of oligodendrocyte precursor cells DOI

Jingjing Bu,

Yuan Liu, Yufang Zhao

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks DOI Creative Commons
Ivana Kawiková, Václav Špička,

James C. K. Lai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Language: Английский

Citations

0