Zero- to ultralow-field nuclear magnetic resonance

Progress in Nuclear Magnetic Resonance Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 101558 - 101558

Published: Feb. 1, 2025

Language: Английский

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Live magnetic observation of parahydrogen hyperpolarization dynamics

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 15, 2024

Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable by classical polarization techniques, making them widely used as sensors physics, chemistry, and medicine. The state of a hyperpolarized material, however, typically only studied indirectly with partial destruction magnetization, due to the nature conventional detection resonant-pickup NMR spectroscopy or imaging. Here, we establish atomic magnetometers sub-pT sensitivity an alternative modality detect real time complex dynamics materials without disturbing interrupting magnetogenesis process. As example are impossible means, examine parahydrogen-induced 1 H 13 C during adiabatic eigenbasis transformations at μ T-field avoided crossings. Continuous but nondestructive magnetometry reveals previously unseen spin dynamics, fidelity limits, backaction effects. second example, apply observe chemical-exchange-driven hyperpolarization [1– C]-pyruvate—the most important tracer for clinical metabolic approach can be readily combined other high-sensitivity applicable broader range general observation scenarios involving production, transport, systems interaction compounds.

Language: Английский

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Characterization of Nuclear Magnetism At Ultralow and Zero Field Using SQUIDs

IEEE Transactions on Applied Superconductivity, Journal Year: 2025, Volume and Issue: 35(5), P. 1 - 5

Published: Jan. 9, 2025

Nuclear magnetism underpins areas such as medicine in magnetic resonance imaging (MRI). Hyperpolarization of nuclei enhances the quantity and quality information that can be determined from these techniques by increasing their signal to noise ratios orders magnitude. However, some hyperpolarization rely on use low ultralow fields (ULF) (nTs-mTs). The broadband character ultrasensitive field sensitivity superconducting quantum interference devices (SQUID) allow for probing nuclear at fields, where other magnetometers, Faraday coils flux gates do not. To this end, we designed a reactor hyperpolarize [1- ¹³ C]pyruvate with technique, amplification reversible exchange shield enables alignment transfer heteronuclei (SABRE-SHEATH). Hyperpolarized pyruvate has been shown very powerful diagnosis tumours MRI its metabolism is associated various pathologies. We were able characterize our setup simulating filled relation placement noise, ULF setup. Using simulations, results C polarization 0.4%, enhancement $\sim$ 100 000 versus predicted thermal equilibrium earth ( 50 notation="LaTeX">$\mu$ T). This 6.20 notation="LaTeX">$\pm$ 0.34 pT, which setup, opens possibility direct observation subsequent spin-lattice relaxation without system perturbation.

Language: Английский

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Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 6386 - 6409

Published: April 4, 2025

Nuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine. This review examines recent chemical biochemical insights gained using parahydrogen-induced polarization (PHIP). We begin with photoinduced PHIP, which allows investigation of short-lived photoactivated catalysis. Next, we partially negative line effect, distinctive shape helps to reveal information about rapid exchange role catalytic species. The NMR signal enhancement a single proton oneH-PHIP is discussed, challenging underpinning concept necessity pairwise hydrogenation. Furthermore, examine metal-free PHIP facilitated by frustrated Lewis pair molecular tweezers radicaloids, demonstrating alternative routes Although symmetric molecules incorporating are silent, showcase methods that hyperpolarized states through post-hydrogenation reactions. discuss processes mediate transfer between target, expanding reach without synthesizing specialized precursors. conclude this highlighting uncovering H2 activation mechanisms hydrogenases. By providing detailed these diverse phenomena, aim familiarize reader versatility its mechanistic studies analysis.

Language: Английский

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Fluxonium-based superconducting qubit magnetometer: Optimization of phase estimation algorithms

Physical review. B./Physical review. B, Journal Year: 2024, Volume and Issue: 110(21)

Published: Dec. 16, 2024

High-precision magnetometers have found wide applications in medicine, geological exploration, material property studies, and other fields of human activity. Recently, there has been significant development based on the evolution quantum system states under influence an external magnetic field. A notable example such a is fluxonium superconducting qubit. In this paper, we evaluate performance low-frequency field sensor The analysis utilizes parameters from qubits implemented by various experimental groups. We compare fluxonium-based magnetometer with that interference devices. Our calculations show are capable high-precision measurements high intrinsic inductance loop allows efficient coupling auxiliary antennas. Moreover, propose algorithm upgrade for using qubits, which could enhance measurement accuracy approximately factor two compared to existing qubit-based algorithms.

Language: Английский

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