Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion DOI
Martin Gierse, Laurynas Dagys,

Michael Keim

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(34)

Published: May 28, 2024

Abstract Parahydrogen‐induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with levels of >10 % in the solution‐state, but strongly limited generality since it requires chemical reactions/ interactions H 2 . Here we report a new method widen scope PHIP hyperpolarization: source molecule produced via high 13 C polarization, and precipitated out solution together target species. Spin diffusion within solid carries onto spins target, which can then be dissolved for solution‐state applications. We name this PHIP‐SSD (PHIP solid‐state spin diffusion) demonstrate using PHIP‐polarized [1‐ C]‐fumarate as molecule, polarize different C‐labelled molecules. polarizations between 0.01 3 were measured on C]‐benzoic acid, depending molar ratio fumarate:benzoate state. also show that does not require specific co‐crystallization conditions by grinding dry powders fumarate crystals, obtain signal enhancements 100 200 [ C, 15 N ]‐urea, C]‐pyruvate, acid. This approach appears promising strategy facile hyperpolarization based PHIP.

Language: Английский

Zero- to ultralow-field nuclear magnetic resonance DOI Creative Commons
Danila A. Barskiy, John W. Blanchard, Dmitry Budker

et al.

Progress in Nuclear Magnetic Resonance Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 101558 - 101558

Published: Feb. 1, 2025

Language: Английский

Citations

2
NMRduino: A modular, open-source, low-field magnetic resonance platform DOI Creative Commons
Michael C. D. Tayler, Sven Bodenstedt

Journal of Magnetic Resonance, Journal Year: 2024, Volume and Issue: 362, P. 107665 - 107665

Published: March 24, 2024

The NMRduino is a compact, cost-effective, sub-MHz NMR spectrometer that utilizes readily available open-source hardware and software components. One of its aims to simplify the processes instrument setup data acquisition control make experimental spectroscopy accessible broader audience. In this introductory paper, key features potential applications are described highlight versatility both for research education.

Language: Английский

Citations

7
Live magnetic observation of parahydrogen hyperpolarization dynamics DOI Creative Commons
James Eills, Morgan W. Mitchell,

Irene Marco Rius

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 15, 2024

Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable by classical polarization techniques, making them widely used as sensors physics, chemistry, and medicine. The state of a hyperpolarized material, however, typically only studied indirectly with partial destruction magnetization, due to the nature conventional detection resonant-pickup NMR spectroscopy or imaging. Here, we establish atomic magnetometers sub-pT sensitivity an alternative modality detect real time complex dynamics materials without disturbing interrupting magnetogenesis process. As example are impossible means, examine parahydrogen-induced 1 H 13 C during adiabatic eigenbasis transformations at μ T-field avoided crossings. Continuous but nondestructive magnetometry reveals previously unseen spin dynamics, fidelity limits, backaction effects. second example, apply observe chemical-exchange-driven hyperpolarization [1– C]-pyruvate—the most important tracer for clinical metabolic approach can be readily combined other high-sensitivity applicable broader range general observation scenarios involving production, transport, systems interaction compounds.

Language: Английский

Citations

6
Characterization of Nuclear Magnetism At Ultralow and Zero Field Using SQUIDs DOI
John Z. Myers, Kai Buckenmaier, Andrey N. Pravdivtsev

et al.

IEEE Transactions on Applied Superconductivity, Journal Year: 2025, Volume and Issue: 35(5), P. 1 - 5

Published: Jan. 9, 2025

Nuclear magnetism underpins areas such as medicine in magnetic resonance imaging (MRI). Hyperpolarization of nuclei enhances the quantity and quality information that can be determined from these techniques by increasing their signal to noise ratios orders magnitude. However, some hyperpolarization rely on use low ultralow fields (ULF) (nTs-mTs). The broadband character ultrasensitive field sensitivity superconducting quantum interference devices (SQUID) allow for probing nuclear at fields, where other magnetometers, Faraday coils flux gates do not. To this end, we designed a reactor hyperpolarize [1- 13 C]pyruvate with technique, amplification reversible exchange shield enables alignment transfer heteronuclei (SABRE-SHEATH). Hyperpolarized pyruvate has been shown very powerful diagnosis tumours MRI its metabolism is associated various pathologies. We were able characterize our setup simulating filled relation placement noise, ULF setup. Using simulations, results C polarization 0.4%, enhancement $\sim$ 100 000 versus predicted thermal equilibrium earth ( 50 notation="LaTeX">$\mu$ T). This 6.20 notation="LaTeX">$\pm$ 0.34 pT, which setup, opens possibility direct observation subsequent spin-lattice relaxation without system perturbation.

Language: Английский

Citations

0
Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion DOI
Martin Gierse, Laurynas Dagys,

Michael Keim

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: May 28, 2024

Parahydrogen-induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with levels of >10 % in the solution-state, but strongly limited generality since it requires chemical reactions/ interactions H

Language: Английский

Citations

1
Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion DOI
Martin Gierse, Laurynas Dagys,

Michael Keim

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(34)

Published: May 28, 2024

Abstract Parahydrogen‐induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with levels of >10 % in the solution‐state, but strongly limited generality since it requires chemical reactions/ interactions H 2 . Here we report a new method widen scope PHIP hyperpolarization: source molecule produced via high 13 C polarization, and precipitated out solution together target species. Spin diffusion within solid carries onto spins target, which can then be dissolved for solution‐state applications. We name this PHIP‐SSD (PHIP solid‐state spin diffusion) demonstrate using PHIP‐polarized [1‐ C]‐fumarate as molecule, polarize different C‐labelled molecules. polarizations between 0.01 3 were measured on C]‐benzoic acid, depending molar ratio fumarate:benzoate state. also show that does not require specific co‐crystallization conditions by grinding dry powders fumarate crystals, obtain signal enhancements 100 200 [ C, 15 N ]‐urea, C]‐pyruvate, acid. This approach appears promising strategy facile hyperpolarization based PHIP.

Language: Английский

Citations

1