Lichen planus following Covid-19 vaccination: a narrative review DOI

Michela D’Agostino,

Fabrizio Martora, Matteo Megna

et al.

Clinical and Experimental Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 25, 2024

Lichen planus (LP) is an inflammatory disease that afflicts skin, mucous membranes, cutaneous appendages. Moreover, LP represents a prototype of lichenoid dermatosis, being characterized by the presence dense dermal cell infiltrate. Although most cases are idiopathic, infectious and drug-related factors must also be considered in etiology. In this context, occurrence drug eruption following different types vaccination possible event. Therefore, aim our review to provide broad perspective clinicians analyzing current literature eruptions COVID-19 vaccination, investigating pathogenetic mechanisms underlying phenomenon. A total 61 have been collected. However, number extremely low if compared vaccines administered overall, suggesting risk low. Certainly, further studies desirable identify population at possibility taking preventive measures.

Language: Английский

The mRNA-LNP vaccines – the good, the bad and the ugly? DOI Creative Commons
Botond Z. Igyártó, Zhen Qin

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as basis of most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these were deemed safe and effective for all demographics. However, latest data raise serious concerns about safety effectiveness vaccines. Here, we review some efficacy identified to date. We also discuss potential mechanism observed adverse events related use whether they can be mitigated by alterations this approach.

Language: Английский

Citations

15
Plaque Psoriasis Exacerbation and COVID-19 Vaccination: Assessing the Characteristics of the Flare and the Exposome Parameters DOI Creative Commons
Emmanouil Karampinis, Myrto-Maria Papadopoulou,

Kleoniki Chaidaki

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 178 - 178

Published: Feb. 9, 2024

The diverse patient population and widespread vaccination in the COVD-19 era make vaccine-triggered episodes of psoriasis an ideal model exposome research. This scenario explores fine balance between protective exacerbating factors, providing insights into complex relationship environmental exposure immunopathogenesis when a trigger appears, such as that hyperinflammatory state induced by COVID-19 vaccine. Analyzing interactions vaccine-induced phenomena parameters may provide clinically relevant information important for personalized medicine decision-making. We performed literature review seeking patients with plaque flares or new onset change another subtype, pustular erythrodermic flare, focusing on inner external traits patients. identified 71 flares, 12 new-onset psoriasis, 17 subtype change, assessed terms clinical presentation, post-vaccination flare period treatment status, well (genomics, oxidative stress, hormonal impact due to gender, aging, skin color) (UV, infectomics). Novel data following are primarily obtained combining episode features characteristics comparing them similar unrelated vaccination.

Language: Английский

Citations

13
Dermatological Manifestations of COVID-19: A Comprehensive Review DOI

Violet Munarov,

Jonathan Munarov,

Naeem Ahmad

et al.

Physician s Journal of Medicine, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 4, 2025

Background:COVID-19, caused by SARS-CoV-2, manifests in multiple organ systems, including the skin, presenting a range of dermatologic symptoms. Recognizing these cutaneous signs is essential, as they often appear early or alongside respiratory symptoms, aiding diagnosis and management. Key skin manifestations include pernio-like lesions (COVID toes), maculopapular rashes, urticarial eruptions, vesicular lesions, vascular-related signs, each potentially valuable for prognostic assessment. Methods:A systematic review major databases, PubMed, Google Scholar, Scopus, Web Science, was conducted. Studies published between 2015 2024 were included, focusing on prevalence, pathophysiology, clinical significance COVID-19-related lesions. Selection criteria prioritized case reports, series, cohort studies, reviews reporting quantitative data presentations. Main Findings:COVID-19-associated symptoms vary prevalence severity, with rashes COVID toes being among most common. Notably, vascular are linked to severe cases may serve indicators coagulopathy cytokine storms. Cutaneous can precede absence offering clinicians window detection. Histopathological findings reveal immune-mediated mechanisms, suggesting could signal systemic inflammation COVID-19. Conclusion:The diverse COVID-19 underscore need assessment patient care. These support integration dermatology into care teams, especially cases, where correlate complications. Further research pathophysiology long-term effects essential advancing diagnostic approaches, reinforcing role comprehensive

Language: Английский

Citations

0
Infectious exanthemas in clinical practice DOI
В. А. Боднар, N. O. Pryimenko, Olena Marchenko

et al.

Wiadomości Lekarskie, Journal Year: 2025, Volume and Issue: 1, P. 168 - 176

Published: Jan. 31, 2025

The aim: Analyze the causes and mechanisms of development exanthems, provide a classification morphological elements characterize clinical manifestations rash in patients with infectious diseases based on review available literature data. Materials methods: authors analyzed current sources, including description exanthema syndrome discussion features rashes various diseases. Conclusions: As result analysis existing data, it was established that is associated diseases, disorders pathological conditions, characterized by variety manifestations, which requires differential diagnosis subsequent laboratory confirmation. Comprehensive knowledge causes, development, as well skin will contribute to an improved algorithm for treatment accompanied syndrome, optimization therapeutic tactics.

Language: Английский

Citations

0
Cutaneous Manifestations of COVID‐19: A Descriptive Analysis of a Southeastern USA Purposive Sample DOI Creative Commons

Shannon S. Layton,

Shea Polancich, Julie Schexnayder

et al.

International Wound Journal, Journal Year: 2025, Volume and Issue: 22(4)

Published: March 30, 2025

ABSTRACT This study describes characteristics and factors associated with cutaneous manifestations of COVID‐19 encountered across acute inpatient, critical care units in a large Southeastern USA public hospital from March 1, 2020, through November 01, 2021. A retrospective descriptive analysis was conducted on purposive sample patients consulted for non‐pressure injury related wounds while positive COVID‐19. Patients were predominantly male (64.3%, n = 27), White (66.7%, 28) Black (33.3%). No observed Hispanic patients. Patient mortality 71.4% ( 30). Gender distribution proportionate by gender (67% male) race (65.5% White) deceased Body mass index (BMI) ranged 15.8 to 61.2 mean 31.9 (SD 10.76) median BMI 28.7. Identification understanding the retiform purpura pathophysiology could prove useful guiding treatment regimens. Investigation into preventing complement cascading those ethnicity may be prevention CMC‐19 progression severity illness.

Language: Английский

Citations

0
Right Biceps Pseudo-Tumor from COVID-19 Vaccination DOI Creative Commons
Anas M. Abbas, Martha Caicedo, Timothy A. Damron

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 160 - 160

Published: Feb. 3, 2024

Delayed hypersensitivity reactions (DHRs) have been reported in association with COVID-19 vaccines, particularly those that are mRNA-based. Classic DHRs result induration, erythema, tenderness, and urticaria. However, soft tissue mass is an uncommon complication of a vaccination-associated DHR rarely the literature. We present case 49-year-old male who recognized mildly painful, firm within biceps mimicking neoplasm six months after receiving booster dose Moderna vaccine. Non-operative conservative treatment modalities, including heating pads, ice packs, acetaminophen, ibuprofen, failed to improve patient’s mass. The mass, which proved histologically be inflammatory pseudo-tumor, did not recur complete excision. While there many cases following vaccinations, we this raise awareness development pseudo-tumors as possible, yet rare, clinical manifestation vaccination.

Language: Английский

Citations

2
Viral reactivation following COVID-19 vaccination: a review of the current literature DOI
Fabrizio Martora, Matteo Megna, Teresa Battista

et al.

Clinical and Experimental Dermatology, Journal Year: 2024, Volume and Issue: 49(6), P. 556 - 565

Published: Feb. 20, 2024

Abstract Currently, four vaccines for COVID-19 have been licensed by the European Medicines Agency: two viral vector-based and mRNA-based vaccines. Since their approval, several cutaneous reactions related to vaccination reported in literature. Among these, reactivations are one of most frequent. The aim this article was investigate current literature regarding following vaccination, focusing attention on pityriasis rosea (PR), herpes zoster simplex. A comprehensive search using various databases performed we included metanalyses, reviews, letters editor, real-life studies, case series reports. total 48 articles involving 2067 patients were selected. Of 32, 6 17 varicella virus (VZV) reactivation (1758 patients), simplex (HSV) (238 patients) onset PR (71 respectively (some discussed more than these three reactivations). Possible pathogenetic mechanisms underlying still not understood. Also, possible correlations between should be clarified. Certainly, discouraged.

Language: Английский

Citations

2
Immunogenicity, Effectiveness, and Safety of COVID-19 Vaccines among Patients with Immune-Mediated Dermatological Diseases: A Systematic Review and Meta-analysis DOI Creative Commons
Sonphet Chirasuthat, Yanisa Ratanapokasatit, Kunlawat Thadanipon

et al.

Acta Dermato Venereologica, Journal Year: 2024, Volume and Issue: 104, P. adv40009 - adv40009

Published: May 2, 2024

Immunocompromised individuals, primarily attributable to using immunosuppressants, face heightened COVID-19 risks. Despite the proven efficacy of vaccines, their impact on patients with immune-mediated dermatological diseases remains unclear. This study aims thoroughly examine vaccine immunogenicity, effectiveness, and safety in disease patients. Clinical studies adults that compared vaccinated healthy controls or unvaccinated terms infection, adverse events, exacerbation were searched via electronic databases. Seventeen (1,348,690 participants) included. Seroconversion rates between not different. However, among individuals aged ≤55 years, had lower mean anti-SARS-CoV-2 IgG levels. Immunosuppressed also titres less likely achieve T-cell response. In safety, risk events was higher atopic dermatitis patients, but those psoriasis a reduced risk. Additionally, immunosuppressed fewer events. Vaccinated infection than controls; however, may be induced. conclusion, showed response our meta-analysis, yet vaccination remained effective against well tolerated.

Language: Английский

Citations

2
The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection DOI Creative Commons

Monika Zaborska,

Maksymilan Chruszcz,

Jakub Sadowski

et al.

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(6)

Published: May 31, 2024

Abstract Scientists from various areas of the world indicate in their studies that skin lesions occur course infection with SARS-CoV-2 virus. This article is a review most frequently described cutaneous manifestations virus and potential pathophysiology development, as well information on abnormalities histopathological tests. The describes impact some factors related to COVID-19 pandemic exacerbation chronic dermatological diseases. work was constructed basis 142 research studies, reviews, meta-analyses, focusing methods materials used individual works results conclusions resulting them. Some may be prognostic marker disease also prodromal symptom or only infection. Stress exacerbate A correlation observed between type patient’s age. occurrence diseases influenced by drugs treat infections caused SARS-CoV-2. relationship ethnic origin occurring COVID-19. There need further diagnose learn detailed pathomechanism order better understand essence find an appropriate treatment method.

Language: Английский

Citations

2
Musculoskeletal manifestations of COVID-19 DOI
Lucas N. M. da Silva, Alípio Gomes Ormond Filho, Júlio Brandão Guimarães

et al.

Skeletal Radiology, Journal Year: 2023, Volume and Issue: 53(10), P. 2009 - 2022

Published: Dec. 20, 2023

Language: Английский

Citations

4