Journal of Food Biochemistry,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Tea
plants,
as
essential
health
beverages,
are
widely
recognized
for
their
rich
content
of
antioxidant
metabolites.
This
study
utilized
metabolomics
analysis
techniques
to
compare
the
metabolic
differences
between
Camellia
tachangensis
F.
C.
Zhang,
gymnogyna
Hung
T.
Chang,
and
sinensis
(L.)
O.
Kunzte,
aiming
reveal
potential
activities.
By
applying
UPLC–MS/MS
technology,
we
analyzed
metabolites
in
samples
identified
1056
We
statistical
methods
such
orthogonal
partial
least
squares
discriminant
(OPLS‐DA)
principal
component
evaluate
variations
samples.
An
intersection
from
three
types
tea
plants
29
major
differential
Functional
annotation
pathway
these
were
conducted,
ultimately
discussing
24
antioxidant‐related
metabolites,
primarily
belonging
flavonoids,
phenolic
acids,
other
categories.
Among
tea,
has
highest
procyanidin
B4,
which
is
most
abundant
substance
this
tea.
In
terms
impact
on
it
known
have
properties
contributes
overall
capacity
both
,
top
5
include
substances
apigenin‐6,8‐di‐C‐glucoside
(vicenin‐2),
epigallocatechin,
apigenin‐5‐O‐glucoside.
These
belong
flavonoid
class
contribute
teas.
Beyond
flavonoids
classes
also
exhibited
significant
properties.
different
play
a
key
role
function
contributing
benefits.
The
provide
crucial
insights
exploring
developing
high‐antioxidant
products
that
occur
naturally.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 8, 2025
Vanillic
Acid
(VA)
is
an
aromatic
acid
extracted
from
traditional
Chinese
medicine
such
as
Angelica
sinensis
and
Panax
ginseng,
which
has
demonstrated
potent
anti-cancer
activity,
inhibiting
the
onset
progression
of
various
malignant
tumors.
This
review
highlights
principal
mechanism
by
VA
exerts
its
anticancer
including
apoptosis
induction,
specifically
promoting
generation
intracellular
reactive
oxygen
species
(ROS),
in
turn
triggers
mitochondrial
apoptosis.
Furthermore,
disrupts
cancer
cell
cycle,
arresting
most
cells
at
G1
phase,
curtails
migration,
invasion,
angiogenesis,
potentiates
therapeutic
efficacy
chemotherapeutic
drugs,
all
while
minimizing
adverse
reactions.
paper
offers
a
comprehensive
VA's
anti-tumor
effects
underlying
mechanisms,
aiming
to
provide
some
references
for
scientists
clinical
physicians
research
strategies.
BMC Pharmacology and Toxicology,
Journal Year:
2023,
Volume and Issue:
24(1)
Published: May 19, 2023
Abstract
Background
Methamphetamine
is
widely
abused
in
all
parts
of
the
world.
It
has
been
reported
that
short-term
and
long-term
methamphetamine
exposure
could
damage
dopaminergic
system
induce
cardiomyopathy
cardiotoxicity
via
mitochondrial
dysfunction
oxidative
stress.
Vanillic
acid
(VA),
a
phenolic
compound
derived
from
plants,
known
for
its
antioxidant
protection
properties.
Methods
In
current
study
we
used
VA
attenuating
Methamphetamine-induced
toxicity
cardiac
mitochondria.
Isolated
mitochondria
obtained
rat
heart
were
grouped
as:
control,
(250
µM),
(10,
50
100
µM)
was
cotreated
with
(100
alone.
After
60
min,
fraction
including:
succinate
dehydrogenases
(SDH)
activity,
membrane
potential
(MMP),
swelling,
glutathione
(GSH),
reactive
oxygen
species
(ROS)
lipid
peroxidation
(LPO)
evaluated.
Results
significantly
disrupted
function
induced
ROS
formation,
peroxidation,
GSH
depletion,
MMP
collapse
while
increased
SDH
activity
as
indicator
dysfunction.
also
decreased
depletion
presence
methamphetamine.
Conclusion
These
findings
suggested
able
to
reduce
methamphetamine-induced
Our
results
demonstrate
potentially
serve
promising
accessible
cardioprotective
agent
against
cardiotoxicity,
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1773 - 1773
Published: Sept. 18, 2023
Hypertension
and
derived
cardiovascular
disease
(CVD)
are
among
the
leading
causes
of
death
worldwide.
Increased
oxidative
stress
inflammatory
state
involved
in
different
alterations
endothelial
functions
that
contribute
to
onset
CVD.
Polyphenols,
particular
anthocyanins,
have
aroused
great
interest
for
their
antioxidant
effects
cardioprotective
role.
However,
anthocyanins
rarely
detected
blood
serum
because
they
primarily
metabolized
by
gut
microbiota.
This
review
presents
studies
published
date
report
main
results
from
clinical
on
role
microbiota
metabolism
bioavailability
influence
composition
Even
if
it
seems
a
significant
effect
vascular
health,
more
required
better
clarify
which
molecules
doses
show
benefits
without
forgetting
crucial
European Food Research and Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Bee
pollen
continues
to
increase
its
popularity
as
a
‘complete
food’
among
natural
resources
with
high
health
value
and
therapeutic
chemical
compounds.
This
study
focused
on
HPLC-DAD
(high-performance
liquid
chromatography-diode
array
detection)
based
the
identification
of
compounds
Cistus
creticus
,
Helianthus
annuus
Papaver
somniferum
Salix
sp.
bee
pollens.
Also,
water
extracts
fractions
(hexane,
dichloromethane,
ethyl
acetate,
butanol,
water)
obtained
from
methanol
all
pollens
were
investigated
for
A
total
29
screened
kaempferol
was
detected
in
studied
samples
at
concentration
0.4
331.6
µg/g.
Luteolin
(68.7–694.8
µg/g),
trans
-aconitic
acid
(12.2–479.1
myricetin
(160.4–1534.2
quercetin
(162.1–608.1
rosmarinic
(273.8–435.6
rutin
(3.6–202.8
-cinnamic
(5.1–1854.6
µg/g)
found
most
abundant
Additionally,
nonpolar
polar
chemometrically
clustered
similarities
differences
via
principal
component
analysis
(PCA)
hierarchical
cluster
(HCA).
In
fractions,
C.
H.
P.
acetate
(CEA,
HEA,
PEA,
SEA)
separated
other
while
butanol
(CB,
HB,
PB,
SB)
fractions.
provides
additional
data
characterization
valuable
constitutes
beginning
chemometric
classification
Biotechnology for Biofuels and Bioproducts,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Feb. 22, 2025
Lignocellulose
is
the
most
abundant
renewable
bioresource
on
earth,
and
its
biodegradation
utilization
would
contribute
to
sustainable
development
of
global
environment.
Ruminiclostridium
papyrosolvens,
an
anaerobic,
mesophilic,
cellulolytic
bacterium,
produces
enzymatic
complex
known
as
cellulosome.
As
one
highly
evolved
species
among
Ruminiclostridium-type
species,
R.
papyrosolvens
particularly
relevant
for
understanding
how
clostridia
modulate
their
biomass
degradation
mechanisms
in
response
diverse
carbon
sources.
Our
study
investigates
transcriptional
responses
different
sources
understand
lignocellulose
utilization.
Using
RNA-seq,
we
analyzed
gene
expression
under
glucose,
cellobiose,
xylan,
cellulose,
corn
stover,
identifying
distinct
metabolic
preferences
regulatory
responses.
We
found
significant
changes
stover
compared
other
sources,
with
enrichment
ABC
transporters
cell
growth
pathways.
CAZyme
was
regulated
by
TCSs,
affecting
sugar
transporter
systems.
Metabolic
profiling
showed
produced
more
metabolites
during
fermentation,
revealing
adaptability
various
implications
engineering.
This
not
only
uncovers
intricate
hydrolysates,
but
it
also
outlines
strategy
using
a
chassis
genetic
