Acceptance and attitudes towards COVID-19 vaccination during pregnancy in Canada

Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 3, 2025

The COVID-19 pandemic posed a unique set of risks to pregnant women and people. SARS-CoV-2 infection in pregnancy is associated with increased risk severe illness adverse perinatal outcomes. However, evidence regarding the use vaccines shows safety efficacy. Despite eligibility recommendations for vaccination among people Canada, uptake remains lower compared general population, warranting exploration influencing factors. COVERED study, national prospective cohort, utilized web-based surveys collect data from across Canada on vaccine attitudes, uptake, hesitancy factors July 2021 December 2023. Survey questions were informed by validated tools including WHO Vaccine Hesitancy Scale (VHS) Theory Planned Behavior (TPB). Of 1093 respondents who at time survey, 87.7% received or intended receive during pregnancy. TPB variables such as positive attitudes toward (OR = 1.11, 95% CI 1.08–1.14), direct social norms, indirect norms significantly acceptance. Perceived risks, assessed VHS, greater those not accepting vaccine. Our study identified several key that play role uptake: perceived norms. These findings may guide public health prenatal counseling strategies.

Language: Английский

---

Overview of Neural Tube Defects: Gene–Environment Interactions, Preventative Approaches and Future Perspectives

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 965 - 965

Published: April 21, 2022

Neural tube defects (NTDs) are the second most common congenital malformations of humans, characterized by impaired development central nervous system. Even though etiology birth remains undetermined, genetic and environmental risk factors in background NTDs have been identified extensively reported. On top nutritional risks which include mutations both coding non-coding regions maternal folate status, respectively, recent years seen a rise identification variety teratogens that could be implicated NTD development. These polycyclic aromatic hydrocarbons, arsenic, pesticides, hyperthermia antibiotics as well pain seizure medication. With an increase understanding leading to formation, preventative treatment approaches witnessed great advances throughout years. While approach includes folic acid food fortification suggested inositol supplementation, management differ greatly depending on developmental stage site lesion prenatal surgery, stem cell transplantation postnatal surgery. Because still represent large health financial burden for patient society whole, it is crucial investigate potential develop novel order fully prevent this category disorders.

Language: Английский

---

A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 86, P. 104623 - 104623

Published: May 30, 2023

Language: Английский

---

COVID‐19 and novel mRNA vaccines in pregnancy: an updated literature review

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2021, Volume and Issue: 129(1), P. 21 - 28

Published: Oct. 15, 2021

The novel coronavirus, SARS-CoV-2, or COVID-19, has affected the world on a pandemic scale resulting in catastrophic outcomes and deaths. Currently, there is limited safety data specific to mRNA vaccine use pregnant lactating individuals potential risks individual fetus are unknown. We report an updated literature review of current information evidence available aid decision whether vaccinate against COVID-19 currently being made by their healthcare providers so that they able make well-informed recommendation decision.

Language: Английский

---

Management of pregnant women with COVID‐19: A tertiary pandemic center experience on 1416 cases

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 94(3), P. 1074 - 1084

Published: Oct. 29, 2021

The aim of this study is to share the comprehensive experience a tertiary pandemic center on pregnant women with COVID-19 and compare clinical outcomes between pregnancy trimesters. present prospective cohort consisted who were followed up at Ankara City Hospital March 11, 2020 February 20, 2021. Clinical characteristics perinatal compared A total 1416 (1400 singletons 16 twins) evaluated. Twenty-six (1.8%) patients admitted intensive care unit (ICU) maternal mortality was observed in six (0.4%) cases. Pregnancy complications 227 (16.1%) cases preterm labor most common one (n = 42, 2.9%). There 311, 433, 672 first, second, third trimesters pregnancy, respectively. Rates mild severe/critic highest first second trimesters, hospitalization rate trimester. complications, mortality, NICU admission rates similar groups. course disease obstetric may be different among worse even without any coexisting health problems.

Language: Английский

---

Association of initial COVID‐19 vaccine hesitancy with subsequent vaccination among pregnant and postpartum individuals

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2022, Volume and Issue: 129(8), P. 1352 - 1360

Published: April 16, 2022

Abstract Objective To examine the association between initial COVID‐19 vaccine hesitancy and subsequent vaccination among pregnant postpartum individuals. Design Prospective cohort. Setting A Midwestern tertiary‐care academic medical center. Individuals completed a baseline assessment from 22 March 2021 to 2 April 2021, with ascertainment of status at 3–6 months follow‐up. Methods We used multivariable Poisson regression estimate relative risk by status, then characteristics associated vaccination. Main outcome measures Self‐report vaccination, secondarily, consideration those not vaccinated. Results Of 456 individuals (93% pregnant, 7% postpartum) initially surveyed, 290 (64%; 23% 77% provided (median = 17 weeks). these individuals, 40% (116/290) reported upon enrolment, whom 52% Few transitioned during study period hesitant vaccinated (10%); in comparison, 80% who were follow‐up (aRR 0.19, 95% CI 0.11–0.33). Among remained unvaccinated follow‐up, 38% considering compared 71% 0.48, 0.33–0.67). older, parous, employed higher educational attainment more likely be vaccinated, identified as non‐Hispanic black, Medicaid beneficiaries, still less Conclusions persisted over time peripartum period, few later Interventions that address pregnancy are needed.

Language: Английский

---

Over time prevalence of illicit substance use in Saudi Arabia

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(9)

Published: Sept. 1, 2022

Illicit substance use disorder is a chronic brain disease. This disease can lead to many negative health outcomes or even death. Recently, Saudi Arabia’s rank was among the top of world in amphetamine seizures. Drug smuggling as well conflicts and wars surrounding countries might play role that. The current paper aimed review over time prevalence illicit Arabia. To achieve that, we searched through different databases. We also looked United Nations Office on Drugs Crime (UNODC) reports. found few articles talking about Arabia; much that work Khat substance. In end, concluded there considerable need for further research this field. Keywords: Khat, amphetamine, cannabis, drug abuse, abuse

Language: Английский

---

An Update on COVID-19 Vaccination and Pregnancy

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(5), P. 797 - 797

Published: May 6, 2023

Pregnant women are more prone to experience severe COVID-19 disease, including intensive care unit (ICU) admission, use of invasive ventilation, extracorporeal membrane oxygenation (ECMO), and mortality compared non-pregnant individuals. Additionally, research suggests that SARS-CoV-2 infection during pregnancy is linked adverse outcomes, such as preterm birth, preeclampsia, stillbirth, well neonatal hospitalization admission the unit. This review assessed available literature from November 2021 19 March 2023, concerning safety effectiveness vaccination pregnancy. administered not significant events related vaccine or negative obstetric, fetal, outcomes. Moreover, has same in preventing disease pregnant individuals general population. safest most effective method for protect themselves their newborns hospitalization, ICU admission. Thus, should be recommended patients. While immunogenicity appears similar population, needed determine optimal timing benefit neonate.

Language: Английский

---

COVID-19 in Pregnant Women, Maternal—Fetal Involvement, and Vertical Mother-to-Child Transmission: A Systematic Review

Biomedicines, Journal Year: 2022, Volume and Issue: 10(10), P. 2554 - 2554

Published: Oct. 13, 2022

Pregnant women are included in the COVID-19 risk groups even if they do not have any pathology. This requires an analysis of research focused on pregnant to understand impact SARS-CoV-2 their condition. There is also a need know whether there vertical mother-to-child transmission, as well other consequences case woman infected and positive. A systematic review was carried out analyze existing information complications with coronavirus possibility transmission from mother child, registered PROSPERO website searched PubMed, Scopus, CINAHL, Cochrane Library databases. Finally, 22 articles were review. The suggests that child could be exceptionally possible at time delivery or breastfeeding, but through placenta. It interesting point good acceptance vaccination by women, which may reason for low infectivity. Further should provide evidence role breast milk relation SARS-CoV-2.

Language: Английский

---

Maternal and perinatal outcomes of COVID-19 vaccination during pregnancy

Journal of the Turkish-German Gynecological Association, Journal Year: 2023, Volume and Issue: 24(2), P. 120 - 124

Published: June 7, 2023

Objective: To investigate maternal adverse effects and perinatal neonatal outcomes of women receiving coronavirus disease-2019 (COVID-19) vaccination during pregnancy. Material Methods:Seven hundred sixty pregnant who were followed up in obstetrics outpatients included this prospective cohort study.COVID-19 infection histories the patients recorded.Demographic data, including age, parity, presence systemic disease events following COVID-19 recorded.Vaccinated compared with unvaccinated terms outcomes.Results: Among 760 met study criteria, data 425 analyzed.Among these, 55 (13%) unvaccinated, 134 (31%) vaccinated before pregnancy, 236 (56%) pregnancy.Of those vaccinated, 307 (83%) received BioNTech, 52 (14%) CoronaVac, 11 (3%) both CoronaVac BioNTech.The local effect profiles either or pregnancy similar (p=0.159), most common was injection site pain.COVID-19 did not increase ratio abortion (<14 wk), stillbirth (>24 preeclampsia, gestational diabetes mellitus, fetal growth restriction, second-trimester soft marker incidence, time delivery, birth weight, preterm (<37 wk) admission to intensive care unit pregnacy. Conclusion:COVID-19 poor outcomes.Therefore, regarding increased risk morbidity mortality related women, authors propose that should be offered all women.(

Language: Английский

---