ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) EQUITY, JUSTICE AND AUTONOMY IN GHANA DOI Creative Commons

Francis Jojo Moses Kodzo Damalie,

Charles Mawunyo Senaya,

Elikplim Adzo Damalie

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

ABSTRACT Restrictive legislation, which is the main barrier to some assisted reproductive technology (ART) services in many countries, non-existent Ghana. However, ART are concentrated capital cities of only four out sixteen regions, serving predominantly middle- and upper-class individuals. There limited evidence about factors preventing broader access Ghana, this study aims document these barriers. A cross-sectional survey was conducted July 2024 across all 22 fertility centers using two structured questionnaires administered via Google App 61 personnel 104 treatment defaulters. Results showed that mentorship from senior colleagues (65.57%) most common way for professionals acquire skills. Almost (91.80%) offered a full range procedures, but 86.89% advocated regulated practice. They identified high costs (70.49%) lack awareness (16.39%) as significant Among defaulters, 88.47% had sought based on word-of-mouth recommendations, compared 4.8% influenced by traditional or social media. More than half (50.96%) women were their thirties, 48.08% required vitro fertilization (IVF). While 58.65% within five years infertility, 70.2% discontinued due costs, 35.57% partner non-availability. Despite absence restrictive policies Prohibitive non-availability, limit access. expressed need practices.

Language: Английский

Evaluating prognosis in unexplained infertility DOI
Ling Shan Au, Qian Feng, Laxmi Shingshetty

et al.

Fertility and Sterility, Journal Year: 2024, Volume and Issue: 121(5), P. 717 - 729

Published: Feb. 27, 2024

Language: Английский

Citations

4
Assisted Reproductive Technologies (Art) Equity, Justice and Autonomy in Ghana DOI Creative Commons

Francis Jojo Moses Kodzo Damalie,

Charles Mawunyo Senaya,

Elikplim Adzo Damalie

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract Background: Restrictive legislation, which is the main barrier to some assisted reproductive technology services in many countries, non-existent Ghana. However, these are available only burgeoning capital cities of four out sixteen regions country, patronised mainly by middle or upper class society. There a dearth evidence on factors that limit access ART most Ghanaians. This study aims document barriers Materials and methods: A cross-sectional survey was conducted across all twenty-two fertility centres Ghana July 2022 using two structured questionnaires administered separately via Google App sensor personnel treatment defaulters at Hallmark Medicals, Kumasi. Results: Sixty-one professionals 104 clinic responded questionnaires. Mentorship/observership from more experienced senior colleagues locally (65.57%) common mode acquiring knowledge clinical skills ART. Almost (91.80%) offered procedures globally, but 86.89% yearned for regulated practice. They identified high costs (70.49%) lack awareness (16.39%) as Most women who defaulted attendance (88.47%) had visited centre based word-of-mouth recommendations, compared 4.8% did so following traditional social media information. More than half (50.96%) were their thirties, 30.77% forties. (48.08%) them required IVF. good number (58.65%) sought within five years Infertility, 70.2% because prohibitive 35.57% partner non-availability. Conclusion: Even though there complete autonomy Ghana, limited costs, non-availability awareness. Meanwhile, advocated

Language: Английский

Citations

0
Fertility in Celiac Disease: The Impact of Gluten on Male and Female Reproductive Health DOI Open Access
Herbert Wieser, Carolina Ciacci, Carlo Soldaini

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1575 - 1575

Published: May 3, 2025

Celiac disease (CeD) is a chronic immune-mediated disorder of the small intestine triggered by ingestion dietary gluten. This narrative review aims to summarize and critically evaluate recent literature on association between CeD infertility, with an emphasis identifying patterns inconsistencies. Previous studies have reported conflicting findings: while some demonstrate higher prevalence unexplained infertility in patients CeD, others do not support this association. Overall, untreated may be contributing factor especially cases, gluten-free diet (GFD) might improve fertility outcomes. However, general does appear exceed that population. includes evidence both male female examines possible pathophysiological mechanisms, including nutritional deficiencies, effects, sexual dysfunction. Further high-quality prospective are needed determine true impact reproductive health inform screening guidelines.

Language: Английский

Citations

0
Prognosis-based management of unexplained infertility—why not? DOI Creative Commons
Laxmi Shingshetty, Rui Wang, Qian Feng

et al.

Human Reproduction Open, Journal Year: 2024, Volume and Issue: 2024(2)

Published: Jan. 1, 2024

Abstract Up to a half of couples seeking medical assistance for infertility are diagnosed with unexplained infertility, characterized by normal ovulation, tubal patency, and semen analysis results. This condition presents challenge in determining the optimal treatment approach. Available treatments include IUI IVF, but guidelines vary on when offer each. Prognosis-based management is identified as research priority, various prediction models have been developed guide decisions. Prognostic factors female age, duration subfertility, sperm parameters, among others. strategies can enhance cost-effectiveness, safety, patient outcomes, offering less invasive options those good prognoses more aggressive interventions poor prognoses. However, there gap between evidence its clinical application. In this article, we discuss application prognosis-based context highlighting potential improve decision-making outcomes.

Language: Английский

Citations

1
The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature DOI Open Access
Konstantinos Sfakianoudis, Athanasios Zikopoulos, Sokratis Grigoriadis

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4977 - 4977

Published: May 2, 2024

One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development, including infertility. It is of importance to summarize the current evidence regarding clinical utility 1-C metabolism-related biomolecules and methyl donors, namely, folate, betaine, choline, vitamin B12, homocysteine (Hcy), zinc, as potential biomarkers, dietary supplements, culture media supplements in context medically assisted reproduction (MAR). A narrative review literature was conducted PubMed/Medline database. Diet, ageing, endocrine milieu individuals affect both metabolism fertility status. In vitro fertilization (IVF) techniques, conditions particular, have a direct impact on activity gametes embryos. Critical analysis indicated that zinc supplementation cryopreservation may be promising approach reducing oxidative damage, while female serum levels employed possible biomarker for predicting IVF outcomes. Nonetheless, level low, future studies are needed verify these data. processes, redox defense epigenetic regulation, compromised IVF-derived The study lead way towards improving MAR efficiency safety ensuring lifelong health infants.

Language: Английский

Citations

1
Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities DOI Open Access

Oyovwi Mega Obukohwo,

Oyelere Abosede Oreoluwa,

Odewale O. Comfort

et al.

OBM Genetics, Journal Year: 2024, Volume and Issue: 08(02), P. 1 - 28

Published: June 20, 2024

Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide better understanding underlying factors contributing infertility and potentially identify markers that could aid diagnosis treatment condition. A literature was conducted understand infertility. Relevant articles from databases like PubMed Google Scholar were analyzed, covering topics genetics, chromosomal abnormalities, markers, fertility, resulting 50 articles. The revealed there is strong correlation between abnormalities. Several studies have reported an increased rate abnormalities compared those normal fertility. Around 10% had most common being translocations. higher who history recurrent miscarriages. reveals significant component infertility, affected indicating factors. Further needed specific treatment, leading personalized options. Genetic counseling testing should be considered miscarriages potential appropriate support.

Language: Английский

Citations

0
Ambient air pollution decreased normal fertilization rate via the mediation of seminal prosaposin DOI Creative Commons

Luxiang Pan,

Jiali Cai, Lanlan Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116713 - 116713

Published: July 13, 2024

This study focuses on the association between seminal concentration of prosaposin and ambient air pollutants whether affects normal fertilization rate in vitro (IVF) treatment.

Language: Английский

Citations

0
ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) EQUITY, JUSTICE AND AUTONOMY IN GHANA DOI Creative Commons

Francis Jojo Moses Kodzo Damalie,

Charles Mawunyo Senaya,

Elikplim Adzo Damalie

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 19, 2024

ABSTRACT Restrictive legislation, which is the main barrier to some assisted reproductive technology (ART) services in many countries, non-existent Ghana. However, ART are concentrated capital cities of only four out sixteen regions, serving predominantly middle- and upper-class individuals. There limited evidence about factors preventing broader access Ghana, this study aims document these barriers. A cross-sectional survey was conducted July 2024 across all 22 fertility centers using two structured questionnaires administered via Google App 61 personnel 104 treatment defaulters. Results showed that mentorship from senior colleagues (65.57%) most common way for professionals acquire skills. Almost (91.80%) offered a full range procedures, but 86.89% advocated regulated practice. They identified high costs (70.49%) lack awareness (16.39%) as significant Among defaulters, 88.47% had sought based on word-of-mouth recommendations, compared 4.8% influenced by traditional or social media. More than half (50.96%) women were their thirties, 48.08% required vitro fertilization (IVF). While 58.65% within five years infertility, 70.2% discontinued due costs, 35.57% partner non-availability. Despite absence restrictive policies Prohibitive non-availability, limit access. expressed need practices.

Language: Английский

Citations

0