Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

Food Chemistry, Journal Year: 2022, Volume and Issue: 383, P. 132531 - 132531

Published: Feb. 23, 2022

Language: Английский

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Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2288 - 2288

Published: Sept. 25, 2019

Fruit and vegetable intake has been associated with a reduced risk of cardiovascular disease. Quercetin kaempferol are among the most ubiquitous polyphenols in fruit vegetables. Most quercetin plants is attached to sugar moieties rather than free form. The types attachments sugars impact bioavailability, thus bioactivity. This article aims review current literature on bioavailability from food sources evaluate potential effects humans. Foods highest concentrations not necessarily bioavailable sources. Glucoside conjugates which found onions appear have absorbed rapidly metabolized liver circulate as methyl, glucuronide, sulfate metabolites. These metabolites can be measured blood urine assess bioactivity human trials. optimal effective dose reported beneficial effect lowering pressure inflammation 500 mg aglycone Few clinical studies examined high intakes quercetin- kaempferol-rich plants. However, it possible that lower dosage plant could due its higher compared Studies needed benefits rich glycoside conjugates.

Language: Английский

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The Effects of Flavonoids in Cardiovascular Diseases

Molecules, Journal Year: 2020, Volume and Issue: 25(18), P. 4320 - 4320

Published: Sept. 21, 2020

Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation their beneficial effects on cardiovascular system. These favorable exerted by flavonoids mainly due antioxidant properties, which result from ability decrease oxidation low-density lipoproteins, thus improving lipid profiles. The other positive effect system is produce vasodilation regulate apoptotic processes endothelium. Researchers suggested that these effects, including anti-inflammatory function, consequences flavonoids’ potent but studies have shown multiple signaling pathways linked them, suggesting there more mechanisms involved human body. This review aims present latest data classification substances, main action body, physiological pathological status

Language: Английский

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Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

Antioxidants, Journal Year: 2019, Volume and Issue: 8(5), P. 137 - 137

Published: May 18, 2019

Over the past few years, interest in health research has increased, making improved a global goal for 2030. The purpose of such is to ensure healthy lives and promote wellbeing across individuals all ages. It been shown that nutrition plays key role prevention some chronic diseases as obesity, cardiovascular disease, diabetes, cancer. One aspects characterises diet high intake vegetables fruits, both are flavonoid-rich foods. Flavonoids one main subclasses dietary polyphenols possess strong antioxidant activity anti-carcinogenic properties. Moreover, population-based studies have described relationship between cancer risk flavonoid intake. In this context, review was provide an updated evaluation association different types cancers We analysed relevant epidemiological from January 2008 March 2019 using PUBMED Web Science databases. summary, concludes associated with reduced cancer, gastric, breast, prostate, colorectal cancers.

Language: Английский

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Green tea (Camellia sinensis) for the prevention of cancer

Cochrane library, Journal Year: 2020, Volume and Issue: 2021(11)

Published: March 2, 2020

Language: Английский

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Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 13, 2019

Abstract Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; on cancer mortality are scarce and moderating effects of lifestyle risk factors for early unknown. In this prospective cohort study including 56,048 participants the Danish Diet, Cancer, Health crosslinked nationwide registries followed 23 years, there 14,083 deaths. A moderate habitual intake flavonoids inversely associated all-cause, cardiovascular- cancer-related mortality. This strong association plateaus at intakes approximately 500 mg/day. Furthermore, inverse associations between total flavonoid outcomes stronger more linear in smokers than non-smokers, as well heavy (>20 g/d) vs. low-moderate (<20 alcohol consumers. These findings highlight potential to reduce through recommendations increase flavonoid-rich foods, particularly high

Language: Английский

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Understanding mechanisms of antioxidant action in health and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 25(1), P. 13 - 33

Published: Sept. 15, 2023

Language: Английский

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Recent Advances in Potential Health Benefits of Quercetin

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 1020 - 1020

Published: July 18, 2023

Quercetin, a flavonoid found in fruits and vegetables, has been part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, anticancer properties, have extensively studied. strong antioxidant properties enable it to scavenge free radicals, reduce oxidative stress, protect against cellular damage. Quercetin’s anti-inflammatory involve inhibiting the production inflammatory cytokines enzymes, making potential therapeutic agent various conditions. It also exhibits effects by cancer cell proliferation inducing apoptosis. Finally, quercetin cardiovascular benefits such as lowering blood pressure, reducing cholesterol levels, improving endothelial function, promising candidate preventing treating diseases. This review provides an overview chemical structure, biological activities, bioavailability quercetin, well different delivery systems available quercetin. Incorporating quercetin-rich foods into diet or taking supplements may be beneficial maintaining good chronic As research progresses, future perspectives appear promising, with applications nutraceuticals, pharmaceuticals, functional promote overall well-being disease prevention. However, further studies are needed elucidate its mechanisms action, optimize bioavailability, assess long-term safety widespread utilization.

Language: Английский

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Flavonoids and gut health

Current Opinion in Biotechnology, Journal Year: 2020, Volume and Issue: 61, P. 153 - 159

Published: Jan. 15, 2020

Flavonoids are dietary non-nutrient bioactives with antioxidant and anti-inflammatory properties. Fruits, vegetables, nuts, legumes, tea rich in flavonoids. After consumption, flavonoids extensively metabolized by the gut microbiota host tissues. Flavonoid metabolism exhibits extensive variation between individuals. It is plausible that inter-individual differences flavonoid impact immune system. Pre-clinical studies have characterized direct indirect mechanisms which modulate intestinal function. This includes modulation of T cell differentiation, alteration microbiota, cytokines. Defining importance these to human chronic disease will improve recommendations for uses

Language: Английский

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Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns

Molecules, Journal Year: 2021, Volume and Issue: 26(13), P. 4021 - 4021

Published: June 30, 2021

Flavonoids comprise a large group of structurally diverse polyphenolic compounds plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine, etc. Major classes flavonoids include flavonols, flavones, flavanones, flavanols, anthocyanidins, isoflavones, chalcones. Owing to their potential health benefits medicinal significance, now considered an indispensable component variety medicinal, pharmaceutical, nutraceutical, cosmetic preparations. Moreover, play significant role preventing cardiovascular diseases (CVDs), which could be mainly due antioxidant, antiatherogenic, antithrombotic effects. Epidemiological vitro/in vivo evidence antioxidant effects supports the cardioprotective function dietary flavonoids. Further, inhibition LDL oxidation platelet aggregation following regular consumption food containing moderate wine might protect against atherosclerosis thrombosis. One study suggests that daily intake 100 mg through may reduce risk developing morbidity mortality coronary heart disease (CHD) by approximately 10%. This review summarizes with sources implications CVDs including various redox-active (molecular) mechanisms Pharmacokinetic (oral bioavailability, drug metabolism), toxicological, therapeutic aspects also addressed herein future directions for discovery development useful candidates/therapeutic molecules.

Language: Английский

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