Flavonoids as Anticancer Agents

Nutrients, Journal Year: 2020, Volume and Issue: 12(2), P. 457 - 457

Published: Feb. 12, 2020

Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine cocoa-based products the main dietary sources flavonoids. have been shown to possess wide anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate arresting cell cycle, induce apoptosis, autophagy, suppress cancer proliferation invasiveness. dual action regarding ROS homeostasis—they act antioxidants under normal conditions potent pro-oxidants cells triggering apoptotic pathways downregulating pro-inflammatory signaling pathways. This article reviews biochemical properties bioavailability flavonoids, their activity its mechanisms action.

Language: Английский

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Plant Flavonoids: Chemical Characteristics and Biological Activity

Molecules, Journal Year: 2021, Volume and Issue: 26(17), P. 5377 - 5377

Published: Sept. 4, 2021

In recent years, more attention has been paid to natural sources of antioxidants. Flavonoids are substances synthesized in several parts plants that exhibit a high antioxidant capacity. They large family, presenting classes based on their basic structure. have the ability control accumulation reactive oxygen species (ROS) via scavenger ROS when they formed. Therefore, these compounds an important role plant stress tolerance and relevance human health, mainly due anti-inflammatory antimicrobial properties. addition, flavonoids applications food industry as preservatives, pigments, antioxidants, well other industries such cosmetics pharmaceuticals. However, application for industrial purposes implies extraction processes with purity quality. Several methodologies developed aimed at increasing flavonoid yield being environmentally friendly. This review presents most abundant flavonoids, structure chemical characteristics, methods, biological activity.

Language: Английский

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Concept, mechanism, and applications of phenolic antioxidants in foods

Journal of Food Biochemistry, Journal Year: 2020, Volume and Issue: 44(9)

Published: July 20, 2020

In this review, the concept of phenolic antioxidants, mechanisms action, and applications have been reviewed. Phenolic compounds (PCs) acts as an antioxidant by reacting with a variety free radicals. The mechanism actions involved either hydrogen atom transfer, transfer single electron, sequential proton loss electron chelation transition metals. foods, PCs act antioxidants which are measured several in vitro spectroscopic methods. found milk wide range dairy products sole purposes color, taste, storage stability, quality enhancement. role three types food additives, that is, antimicrobial, antioxidant, flavoring agents critically literature revealed present foods possess health benefits such antibacterial, antihyperlipidemic, anticancer, cardioprotective, neuroprotective, antidiabetic properties. Practical strong safer than synthetic antioxidants. occurrence plant warranted continuous review applications. This therefore, presented updated comprehensive overview concept, mechanism, foods.

Language: Английский

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Extraction of Flavonoids From Natural Sources Using Modern Techniques

Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 25, 2020

Flavonoids are one of the main groups polyphenols found in natural products. Traditional flavonoid extraction techniques being replaced by advanced to reduce energy and solvent consumption, increase efficiency selectivity, meet increased market demand environmental regulations. Advanced technologies, such as microwaves, ultrasound, pressurized liquids, supercritical fluids, electric fields, alternatives currently used. These modern generally faster, more environmentally friendly, with higher automation levels compared conventional techniques. This review will discuss different methods available for from sources parameters involved (temperature, solvent, sample quantity, time, among others). Recent trends their industrial importance also discussed detail, providing insight into potential. Thus, this paper seeks innovations compound techniques, presenting each them advantages disadvantages, trying offer a broader scope understanding plant matrices.

Language: Английский

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A review on anti-cancer properties of Quercetin in breast cancer

Life Sciences, Journal Year: 2020, Volume and Issue: 248, P. 117463 - 117463

Published: Feb. 22, 2020

Language: Английский

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The style and substance of plant flavonoid decoration; towards defining both structure and function

Phytochemistry, Journal Year: 2020, Volume and Issue: 174, P. 112347 - 112347

Published: April 25, 2020

Over 8000 different flavonoids have been described and a considerable number of new flavonoid structures are being elucidated every year. The advent metabolomics alongside the development phytochemical genetics – wherein genetic basis underlying regulation levels plant metabolites is determined has provided massive boost to such efforts. That said our understanding individual function(s) vast majority that constitute this important class phytochemicals remains unknown. Here we review what known concerning major decorative modifications in plants, namely hydroxylation, glycosylation, methylation acylation. Our focus with regard planta function these modified compounds, however, also highlight demonstrated bioactive roles which they possess. We additionally performed comprehensive survey listed KNApSAcK database order assess frequency occurrence each type modification. conclude whilst research carried out regarding biological most studies date merely information on compound or sub-classes thereof as whole too little currently specific role metabolites. We, therefore, finally suggest framework based available tools by relative importance compounds can be assessed under various conditions fill knowledge-gap.

Language: Английский

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Naringenin: A potential flavonoid phytochemical for cancer therapy

Life Sciences, Journal Year: 2022, Volume and Issue: 305, P. 120752 - 120752

Published: June 29, 2022

Language: Английский

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Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1686 - 1686

Published: July 13, 2022

Naringin and naringenin are the main bioactive polyphenols in citrus fruits, consumption of which is beneficial for human health has been practiced since ancient times. Numerous studies have reported these substances' antioxidant antiandrogenic properties, as well their ability to protect from inflammation cancer, various vitro vivo experimental models animals humans. can suppress cancer development body parts, alleviating conditions patients by acting effective alternative supplementary remedies. Their anticancer activities pleiotropic, they modulate different cellular signaling pathways, cytokine growth factor production arrest cell cycle. In this narrative review, we discuss effects naringin on inflammation, apoptosis, proliferation, angiogenesis, metastasis invasion processes potential become innovative safe drugs.

Language: Английский

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Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 761 - 761

Published: March 13, 2020

Breast cancer is a common that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast incidence flavonoid intake. The anti-cancer action of flavonoids, class polyphenolic compounds are present in plants, as secondary metabolites has been major topic research for many years. Our review analysis demonstrates flavonoids exhibit activity against occurring ethnic populations. subtype menopausal status the key factors inducing flavonoid’s cancer. dose another factor, with showing approximately 10 mg/day isoflavones required inhibit occurrence. In addition, also influence machinery cancer, demonstrating epigallocatechin, genistein, resveratrol all inhibited DNA methyltransferase altered chromatin modification These can induce expression tumor suppressor genes may contribute decreasing progression metastasis. Additional confirm contribution modifications by prevention.

Language: Английский

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Flavonoids in Cancer Metastasis

Cancers, Journal Year: 2020, Volume and Issue: 12(6), P. 1498 - 1498

Published: June 8, 2020

Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects flavonoids against cancer associated not only with early stages process, but also progression and spread into distant sites. showed potent anti-cancer models vitro vivo, mediated via regulation key signaling pathways involved migration invasion cells metastatic progression, including regulators epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β other contributors complex process spread. Moreover, modulated expression genes improved inflammatory status, part development metastasis. documented clear potential to improve effectiveness conventional chemotherapeutic agents. Most importantly, represent environmentally-friendly cost-effective substances; moreover, wide spectrum different demonstrated safety minimal side during long-termed administration. In addition, bioavailability can be by their conjugation metal ions structural modifications radiation. conclusion, flavonoids, targeting all phases carcinogenesis should implemented clinical research order strengthen use future targeted prevention therapy high-risk individuals patients aggressive disease potential.

Language: Английский

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