Understanding bacterial biofilms: From definition to treatment strategies

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 6, 2023

Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms significant problem treating bacterial infections and one of the main reasons for persistence infections. They can exhibit increased resistance to classical antibiotics cause disease through device-related non-device (tissue) -associated infections, posing severe threat global health issues. Therefore, early detection search new alternative treatments essential suppressing biofilm-associated In this paper, we systematically reviewed biofilms, associated methods, potential treatment strategies, aiming provide researchers with latest progress biofilms.

Language: Английский

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Biofilm formation: mechanistic insights and therapeutic targets

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Dec. 15, 2023

Abstract Biofilms are complex multicellular communities formed by bacteria, and their extracellular polymeric substances observed as surface-attached or non-surface-attached aggregates. Many types of bacterial species found in living hosts environments can form biofilms. These include pathogenic bacteria such Pseudomonas, which act persistent infectious responsible for a wide range chronic diseases well the emergence antibiotic resistance, thereby making them difficult to eliminate. Pseudomonas aeruginosa has emerged model organism studying biofilm formation. In addition, other utilize formation plant colonization environmental persistence. effective aiding colonization, enhancing resistance antimicrobial host immune responses, facilitating cell‒cell signalling exchanges between community bacteria. The lack antibiotics targeting biofilms drug discovery process indicates need design new inhibitors drugs using various strategies different stages Growing that have been developed combat enzymes, those involved quorum sensing adhesion pathways. this review, with primary subject study, we review discuss mechanisms current therapeutic approaches, emphasizing clinical issues associated infections focusing on emerging strategies.

Language: Английский

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Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

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Efficient nitrate and Cr(VI) removal by denitrifier: The mechanism of S. oneidensis MR-1 promoting electron production, transportation and consumption

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133675 - 133675

Published: Feb. 1, 2024

Language: Английский

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Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals

Pathogens, Journal Year: 2024, Volume and Issue: 13(4), P. 320 - 320

Published: April 13, 2024

The importance of addressing the problem biofilms in farm, wild, and companion animals lies their pervasive impact on animal health welfare. Biofilms, as resilient communities microorganisms, pose a persistent challenge causing infections complicating treatment strategies. Recognizing understanding mitigating biofilm formation is critical to ensuring welfare variety settings, from farms wild animals. Effectively this issue not only improves overall individual animals, but also contributes broader goals sustainable agriculture, wildlife conservation, responsible pet ownership. This review examines current diseases elucidates complex processes involved. limitations traditional antibiotic treatments, mechanisms resistance associated with are explored. focus alternative therapeutic strategies control biofilm, illuminating case studies providing valuable context practical insights. In conclusion, highlights exploring emerging approaches mitigate It consolidates existing knowledge, gaps understanding, encourages further research address facet health. comprehensive perspective provided by serves foundation for future investigations interventions improve management biofilm-associated diverse populations.

Language: Английский

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Potentiation effect of the AI-2 signaling molecule on postharvest disease control of pear and loquat by Bacillus amyloliquefaciens and its mechanism

Food Chemistry, Journal Year: 2024, Volume and Issue: 441, P. 138373 - 138373

Published: Jan. 10, 2024

Language: Английский

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A Review on the Interaction of Acetic Acid Bacteria and Microbes in Food Fermentation: A Microbial Ecology Perspective

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2534 - 2534

Published: Aug. 14, 2024

In fermented foods, acetic acid bacteria (AAB), kinds of with a long history utilization, contribute to safety, nutritional, and sensory properties primarily through fermentation. AAB are commonly found in various foods such as vinegar, sour beer, cocoa coffee beans, kefir beverages, kombucha, sourdough. They interact cooperate variety microorganisms, resulting the formation diverse metabolites production distinct flavors. Understanding interactions between other microbes is crucial for effectively controlling utilizing fermentation processes. However, these microbial influenced by factors strain type, nutritional conditions, ecological niches, duration. this review, we examine relationships research methodologies interaction studies yeasts, lactic (LAB), bacilli different food processes involving microorganisms. The objective review identify key models insights gained will provide scientific guidance effective utilization functional microorganisms

Language: Английский

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Starting with screening strains to construct synthetic microbial communities (SynComs) for traditional food fermentation

Food Research International, Journal Year: 2024, Volume and Issue: 190, P. 114557 - 114557

Published: May 27, 2024

Language: Английский

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Ultrasmall Ce-based metal–organic frameworks nanozyme with hydrolytic activity for boosting antibiofilm therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 480, P. 148246 - 148246

Published: Dec. 22, 2023

Language: Английский

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Effect of the structure of chitosan quaternary ammonium salts with different spacer groups on antibacterial and antibiofilm activities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133777 - 133777

Published: July 10, 2024

Language: Английский

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