Impact of Antibiotics on the Genomic Expression ofPseudomonas aeruginosain the East African Community: A Systematic Review DOI Creative Commons
Comfort Danchal Vandu, Ilemobayo Victor Fasogbon, A. B. Agbaje

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract Antimicrobial resistance (AMR) presents a significant health problem globally with the majority of burden coming from lower-middle-income countries. AMR surveillance under One Health paradigm is critical for determining relationships between clinical, animal, and environmental levels. Allowing thorough knowledge interconnected variables contributing to resistance, which enables development effective solutions. This systematic review was conducted determine impact antibiotics on gene expression Pseudomonas spp. In East African Community. A comprehensive literature search across Web Science, Scopus, PubMed databases yielding 284 articles 11 meeting inclusion criteria after screening. We included studies 5 Countries that are part Community, results revealed high prevalence antimicrobial in aeruginosa , rates above 90% most tested antibiotics, exception Amikacin, remained due its limited use. Common genes reported carbapenem-resistant like blaNDM-1 blaVIM common method used disc diffusion at (50%). The also found high-risk clones, such as ST 244 357, were associated multidrug-resistant strains. Environmental isolates showed lower (54%) than clinical pathogens (73%), indicating different selecting pressures. Majority Kenya (30%) Uganda (30%), differences research capabilities healthcare facilities. These findings highlight need more surveillance, stewardship programs, additional prevent antibiotic guide public initiatives region. KEY FINDINGS OF THE STUDY demonstrated substantial including cefepime, meropenem, levofloxacin, ticarcillin-clavulanic acid various Africa. Amikacin be Africa potential treatment choice infections Carbapenem-resistant blaNDM-1, blaOXA-48 large number isolates. High-risk 357 demonstrate clonal spread settings. popular susceptibility testing (50%), owing low cost simplicity. DNA extraction PCR 30% whereas advanced approaches whole genome sequencing less resource constraints. undertaken fewer Tanzania Democratic Republic Congo (20%), demonstrating regional variations capacity resources.

Language: Английский

High Biofilm-Forming Multidrug-Resistant Salmonella Infantis Strains from the Poultry Production Chain DOI Creative Commons
Laura Musa, Valeria Toppi, Valentina Stefanetti

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 595 - 595

Published: June 27, 2024

The ability of

Language: Английский

Citations

6
Low-Concentration Hypochlorous Acid Drinking Water Alleviates Broiler Gut Microbial Load While Preserving Overall Growth Performance DOI Creative Commons
Zonggang Li, Chang Liu, Dongyan Shao

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 48 - 48

Published: Jan. 10, 2025

Hypochlorous acid has been attempted as an additive to animal drinking water in practical farming processes for microbial quality control. Despite its potential, there is still a knowledge gap concerning the effects of hypochlorous on both poultry growth performance and gut load. To address this gap, study was conducted using flow cytometry quantify age-related load broiler manure contents. We observed that effect sustained only during starter phase, with no significant impact throughout entire production cycle. The treatment could reduce fresh cecal convergence duodenum, differences loads between control groups persisted contents later stages. Our findings demonstrate consuming low-concentration over long term can lower cycle without impacting overall performance. Future research or feed additives should incorporate absolute quantification methods achieve more precise assessment microbiota.

Language: Английский

Citations

0
Mycoplasma bovis : A review of vaccination and diagnostic initiatives DOI

Isaac Dayo Olorunshola,

Kabiru Ahmad, A.R. Peters

et al.

CABI Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Mycoplasma bovis infections in cattle constitute a worldwide problem with significant detrimental economic impacts on industry. Mastitis, pneumonia, arthritis, keratoconjunctivitis, otitis media and genital disorders are its clinical manifestations. Presently, no vaccines commercially available; antimicrobial resistance is increasing; diagnostic sensitivity testing needs to be improved; new rapid diagnosis kits eminent for implementation of treatment antimicrobials. We conducted systematic search databases such as PubMed, Scopus, Web Science, Google Scholar, AGRIS African Journals Online (AJOL), from 1995 2024. Searched keywords, as, bovis, M : vaccine development, techniques strain variability using the predefined criteria were used address review objectives. Although they have preventative function, – killed, live attenuated, subunit types face difficulties because M. strains vary widely. Every approach has own set benefits drawbacks, those that been studies include conventional culture identification, serological testing, immunohistochemical demonstration tissues, sophisticated molecular like PCR, qPCR, next-generation sequencing. For early detection, successful treatment, vaccination efficacy monitoring, accurate crucial. Future directions managing -associated diseases improving accessibility creating broad-spectrum vaccinations. By incorporating these developments, it may possible enhance health cattle, promote sustainability livestock production, increase food security. This points urgent need further research innovation advancement support

Language: Английский

Citations

0
Introduction DOI
H. K. Jain, Neeraj Aggarwal

Livestock diseases and management, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 1, 2025

Citations

0
Diagnostic Approaches for Biofilm-Associated Infection in Livestock DOI
Shubham Yadav,

Akshay Nalawade,

Pranali R. Pangam

et al.

Livestock diseases and management, Journal Year: 2025, Volume and Issue: unknown, P. 119 - 134

Published: Jan. 1, 2025

Language: Английский

Citations

0
Plasmid mediated colistin resistance in ESBL producing Enterobacterales based on both phenotypic and molecular analysis in companion and farm animals from Algeria DOI
Manel Merradi,

Fatma Zohra Chebaani,

Nouzha Heleili

et al.

Comparative Immunology Microbiology and Infectious Diseases, Journal Year: 2025, Volume and Issue: 120, P. 102342 - 102342

Published: April 25, 2025

Language: Английский

Citations

0
Molecular Characterization, Antibiotic Resistance, and Biofilm Formation of Escherichia coli Isolated from Commercial Broilers from Four Chinese Provinces DOI Creative Commons
Saqib Nawaz, Muhammad Shoaib, Cuiqin Huang

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1017 - 1017

Published: April 28, 2025

Escherichia coli (E. coli) represents a significant etiological agent of colibacillosis in poultry, resulting considerable economic losses for the global poultry sector. The present study aimed to determine molecular characterization, antibiotic resistance, and biofilm formation E. strains isolated from diseased broilers four provinces China. A total 200 tissue samples were collected intestine, liver, crop, heart, spleen processed microbiological examination. Molecular detection strains, virulence genes, serotypes was performed using polymerase chain reaction (PCR). Antibiotic susceptibility testing assessed disk diffusion 96-well microtiter plate assays. retrieved 68% (136/200) samples. Most resistant enrofloxacin (56%), followed by cefepime (54%), amoxicillin/clavulanate (52%), streptomycin (50%), ampicillin (48%), clindamycin (47%), kanamycin (41%), polymyxin B (37%), tetracycline (35%), sulfamethoxazole/trimethoprim (33%), ceftazidime (31%), meropenem (4.7%), florfenicol (2.9%). Similarly, tested positive at least one gene specific serotypes. Among these, O145 most prevalent serotype, identified 22 isolates (16.2%), O8 (12.5%), O102 (11.8%), O9 (11.0%). tsh (10.2%) gene. This found that 47.1% biofilm-producing, with 62.5% exhibiting weak production, 29.7% mild 7.8% strong production. 24.2% avian pathogenic due presence five or more specifically tsh, ompA, fimC, iss, fyuA, astA, single strain multiplex PCR. recommends continuous surveillance effective control measures reduce burden coli-related infections poultry.

Language: Английский

Citations

0
Antioxidant Potential of Exosomes in Animal Nutrition DOI Creative Commons
Hengyu Jin, Jianxin Liu, Diming Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 964 - 964

Published: Aug. 8, 2024

This review delves into the advantages of exosomes as novel antioxidants in animal nutrition and their potential for regulating oxidative stress. Although traditional nutritional approaches promote stress defense systems mammalian animals, several issues remain to be solved, such low bioavailability, targeted tissue efficiency, high-dose by-effect. As an important candidate offering regulation opportunities concerned with cellular communication, disease prevention, physiology multiple biological systems, mediating redox status has not been well described. A previously reported relationship between system circulating suggested a fundamental both regulator biomarker system. Herein, we effects on animals application nutrition. Then, highlight regulators due higher bioavailability physiological heterogeneity-targeted properties, providing theoretical foundation feed industry application. Therefore, have shown great field They can overcome limitations terms dosage side effects, which will provide unprecedented management may become major breakthrough

Language: Английский

Citations

2
Insights into the Virulence and Antimicrobial Resistance of Staphylococcus hyicus Isolates from Spanish Swine Farms DOI Creative Commons
Óscar Mencía‐Ares,

Eva Ramos-Calvo,

Alba González-Fernández

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 871 - 871

Published: Sept. 11, 2024

is a significant pathogen in swine, primarily causing exudative epidermitis. Addressing

Language: Английский

Citations

1
Recent progress in antibiofilm strategies in the dairy industry DOI Creative Commons
Coralie Goetz,

Laurie Sanschagrin,

Éric Jubinville

et al.

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Biofilm formation allows microorganisms including bacteria to persist on abiotic or biotic surfaces, resist treatments with biocides (disinfectants and antibiotics) evade the immune response in animal hosts much more than they do planktonic form. Bacteria able form biofilm can be troublesome dairy industry, both by causing clinical symptoms livestock colonizing milking devices milk processing equipment, resulting products of lower quality sometimes raising serious food safety issues. In fact, most bacterial species isolated frequently chain have ability biofilm. Common examples include Staphylococcus aureus other staphylococci that infect mammary glands, but also Bacillus spp., Listeria monocytogenes Pseudomonas spp. which cause spoilage foodborne illnesses. The economic losses due industry are considerable, scientists constantly solicited develop new antibiofilm strategies, especially using natural origin. Although number studies this subject area has exploded recent years, vivo efficacy novel approaches remains explored. Used alone increase disinfectants antibiotics, could allow implementation strategies having less impact environment. Their use is expected lead reliance antibiotics treat intramammary infections farms concentrations chemical plants.

Language: Английский

Citations

1