Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs

The Lancet Planetary Health, Journal Year: 2024, Volume and Issue: 8(2), P. e74 - e85

Published: Feb. 1, 2024

BackgroundPhthalates are synthetic chemicals widely used in consumer products and have been identified to contribute preterm birth. Existing studies methodological limitations potential effects of di-2-ethylhexyl phthalate (DEHP) replacements poorly characterised. Attributable fractions costs not quantified, limiting the ability weigh trade-offs involved ongoing use. We aimed leverage a large, diverse US cohort study associations metabolites with birthweight gestational age, estimate attributable adverse birth outcomes associated costs.MethodsIn this prospective analysis we extant data National Institutes Health Environmental influences on Child Outcomes (ECHO) Program from 1998 2022 20 age at birth, birthweight, length, for z-scores. also estimated costs. Mother–child dyads were included if there one or more urinary measurements during index pregnancy; child's birthweight; singleton delivery.FindingsWe 5006 mother–child 13 cohorts ECHO Program. Phthalic acid, diisodecyl (DiDP), di-n-octyl (DnOP), diisononyl (DiNP) most strongly especially compared DEHP other metabolite groupings. Although was (odds ratio 1·45 [95% CI 1·05–2·01]), risks per log10 increase higher phthalic acid (2·71 [1·91–3·83]), DiNP (2·25 [1·67–3·00]), DiDP (1·69 [1·25–2·28]), DnOP (2·90 [1·96–4·23]). 56 595 (sensitivity analyses 24 003–120 116) phthalate-attributable cases 2018 US$3·84 billion 1·63– 8·14 billion).InterpretationIn sample births, exposure DEHP, DiDP, DiNP, decreased increased risk suggesting substantial opportunities prevention. This finding suggests consequences substitution chemically similar phthalates need regulate properties as class.FundingNational Health.

Language: Английский

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Exposure assessment of plastics, phthalate plasticizers and their transformation products in diverse bio-based fertilizers

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170501 - 170501

Published: Feb. 2, 2024

Bio-based fertilizers (BBFs) produced from organic waste have the potential to reduce societal dependence on limited and energy-intensive mineral fertilizers. BBFs, thereby, contribute a circular economy for However, BBFs can contain plastic fragments hazardous additives such as phthalate plasticizers, constituting risk agricultural soils environment. This study assesses exposure associated with phthalates in three types of wastes: food industry (AgriFoodInduWaste), sewage sludge (SewSludge), biowaste (i.e., garden, park, kitchen waste). The wastes were various treatments like drying, anaerobic digestion, vermicomposting. number microplastics (0.045–5 mm) increased AgriFoodInduWaste-BBFs (15–258 particles g−1), SewSludge-BBFs (59–1456 g−1) then Biowaste-BBFs (828–2912 g−1). mostly contained packaging plastics (e.g., polyethylene terephthalate), mass (>10 g kg−1) exceeding EU threshold (3 kg−1, >2 mm). Other small (< 1 non-packaging copolymers) amounts below limit. calculated numbers entering via BBF application was high (107–1010 ha−1y−1), but released <7 kg ha−1y−1) compared (95–156 ha−1y−1). concentrations di(2-ethylhexyl)phthalate (DEHP; < 2.5 mg transformation products 8 low benchmark 50 kg−1 DEHP), attributable impact current phase-out DEHP well degradation during treatment. Biowaste-BBF exposed vermicomposting indicated that worms accumulated (4 kg−1). These results are overall positive implementation studied SewSludge-BBFs. safe use requires reducing improving sorting methods minimize contamination environmental impact.

Language: Английский

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Designing healthier and more sustainable ultraprocessed foods

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(2)

Published: March 1, 2024

Abstract The food industry has been extremely successful in creating a broad range of delicious, affordable, convenient, and safe beverage products. However, many these products are considered to be ultraprocessed foods (UPFs) that contain ingredients processed manner may cause adverse health effects. This review article introduces the concept UPFs briefly discusses fall into this category, including beverages, baked goods, snacks, confectionary, prepared meals, dressings, sauces, spreads, meat analogs. It then correlations between consumption levels diet‐related chronic diseases, such as obesity diabetes. different reasons for proposed ability increase risk diseases critically assessed, displacement whole foods, high energy densities, missing phytochemicals, contamination with packaging chemicals, hyperpalatability, harmful additives, rapid ingestion digestion, toxic reaction Then, potential strategies overcome current problems presented, reducing density, balancing nutritional profile, fortification, increasing satiety response, modulating mastication reengineering structure, precision processing. central argument is it possible reformulate reengineer improve their healthiness sustainability, although still needs proved using rigorous scientific studies.

Language: Английский

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Environmental occurrence and ecotoxicological risks of plastic leachates in aquatic and terrestrial environments

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176728 - 176728

Published: Oct. 9, 2024

Language: Английский

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Asymmetric Janus composite films with superior humidity regulation capabilities for the efficient preservation of strawberry fruit

Food Chemistry, Journal Year: 2025, Volume and Issue: 478, P. 143646 - 143646

Published: March 1, 2025

Language: Английский

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A review on takeaway packaging waste: Types, ecological impact, and disposal route

Environmental Pollution, Journal Year: 2023, Volume and Issue: 337, P. 122518 - 122518

Published: Sept. 5, 2023

Language: Английский

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Recent Advances in the Chromatographic Analysis of Emerging Pollutants in Dairy Milk: A Review (2018–2023)

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1296 - 1296

Published: March 14, 2024

Emerging pollutants (EPs) encompass natural or synthetic substances found in the environment that pose potential risks, but which have only recently been recognized monitored. EPs consist of various categories, including pesticides, pharmaceuticals, hormones, mycotoxins, and endocrine-disrupting chemicals (EDCs). Through several pathways, can access food, potentially leading to health impacts when safe concentrations are exceeded. Milk, being a highly nutritious food product is heavily consumed by many consumers different ages, crucial matrix where should be regularly In literature, large number studies dedicated determination dairy milk, employing analytical techniques do so. Chromatography-based most prevalent means used for analysis demonstrating significant efficiency, sensitivity, accuracy this specific purpose. The extraction from complex like milk essential prior performing chromatographic analysis. This review comprehensively covers relevant research papers on subsequent detection using methods 2018 2023.

Language: Английский

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Antioxidants in Mitigating Phthalate-Induced Male Reproductive Toxicity: A Comprehensive Review

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143297 - 143297

Published: Sept. 1, 2024

Language: Английский

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Occurrence of common plastic additives and contaminants in raw, steamed and canned mussel samples from different harvesting areas using MSPD-HPLC methodology

Food Research International, Journal Year: 2024, Volume and Issue: 181, P. 114109 - 114109

Published: Feb. 11, 2024

Microplastics are a complex mix of chemicals containing polymers and certain plastic additives such as bisphenols phthalates. These particles porous materials that can also sorb contaminants from their surroundings, leach the particle under circumstances. Aquatic animals ingest microplastic particles, which mostly bioaccumulate in gastrointestinal tract animals. In terms dietary exposure, small consumed whole mussels, contribute more to intake particles. Plastic not chemically bound polymers, processing methods or cooking processes result release these leaving them available for absorption when ingested. Analytical crucial better understanding occurrence aquatic products, know circumstances treatments influence human exposure. This study uses an MSPD-HPLC methodology simultaneous determination 9 analytes (BPA, BPF, BPS, DEP, DBP, DEHP, DDD, DDT, DDE) analyzing, first time, raw, steamed canned mussels two different harvesting areas (Atlantic Mediterranean), becoming one most efficient methodologies determining presence very food matrices, able define changes activities. The results showed heat pressure treatment could migration present liquids.

Language: Английский

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Co-exposure to 55 endocrine-disrupting chemicals linking diminished sperm quality: Mixture effect, and the role of seminal plasma docosapentaenoic acid

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108571 - 108571

Published: March 1, 2024

Isolated effects of single endocrine-disrupting chemicals (EDCs) on male reproductive health have been studied extensively, but their mixture effect remains unelucidated. Previous research has suggested that consuming diet enriched in omega-3 polyunsaturated fatty acids (PUFA) might be beneficial for health, whether PUFA could moderate the EDCs semen quality to explored. In this study 155 recruited from a center China, we used targeted-exposomics simultaneously measure 55 urine exposure burden. Regression analyses were restricted highly detected (≥55 %, n = 34), and those with consistently elevated risk further screened brought into models (Bisphenol A, ethyl paraben, methyl paraben [MeP], benzophenone-1 [BP1], benzophenone-3, mono(3-carboxypropyl) phthalate [MCPP]). Bayesian Kernel Machine (BKMR) quantile-based g-computation (QGC) demonstrated co-exposure top-ranked was related reduced sperm total (β −0.18, 95 % CI: −0.29 – −0.07, P 0.002) progressive motility −0.27, %CI: −0.43 −0.10, 0.002), not lower volume. BP1, MeP MCPP identified as main driver deteriorated motion parameters using model analyses. Seminal plasma acid profiling showed high status, notably docosapentaenoic (DPA, C22:5n-3) moderated association between (total motility: β 0.26, 0.01 −0.51, Pinteraction 0.047; 0.64, 0.23 1.05, 0.003). Co-exposure range is mainly associated quality, lesser extent quantity, seminal DPA status protective against effect. Our work emphasizes importance exposomic approach assess chemical exposures highlighted new possible intervention target mitigating potential adverse quality.

Language: Английский

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