Gene recognition and role of foodomics in mycotoxin control: A review DOI Creative Commons
U. Samarajeewa

Deleted Journal, Journal Year: 2024, Volume and Issue: 3(1), P. 1857 - 1857

Published: Dec. 9, 2024

Since recognition of toxic and carcinogenic aflatoxins in Brazilian groundnut meal 1960, much research has been done to prevent detoxify foods feeds, identifying a variety methods. The expanded other mycotoxins. biotic abiotic factors favoring mycotoxin contaminations have understood through experiments under laboratory conditions analysis field data. However, many gaps remain the knowledge on control at molecular level that may be useful addressing mycotoxigenic hazards. Recognition responsible genes hosts fungi omics methods applying genomics, transcriptomics, proteomics, metabolomics understand biosynthesis open new avenues interact with plant-fungi-bacteria cross-talks, apply regulatory mechanisms biosynthesis, explore checks controls biosynthesis. is expected generate probable biological eliminate foods. current requires application achieve deeper understanding, aiming for next-generation technologies. This review examines aflatoxins, fusarium toxins, patulin host-fungi interactions level.

Language: Английский

Development of Sheep Intestinal Organoids for Studying Deoxynivalenol-Induced Toxicity DOI Open Access

Hongyu Wang,

Xige He, Miaomiao Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 955 - 955

Published: Jan. 23, 2025

Sheep are an important livestock species whose gastrointestinal tract is essential for overall health. Feed contaminants such as bacterial toxins and mycotoxins severely damage the sheep intestine, yet mechanisms remain mostly elusive partially due to lack of physiologically relevant in vitro models. Here, we investigated molecular underlying deoxynivalenol (DON)-induced toxicity by developing intestinal organoids from isolated crypts Hu sheep. The had a central lumen monolayer epithelium, could be continuously passaged, cryopreserved, resuscitated. Histological transcriptomic analysis showed that recapitulate cell lineages gene expression characteristics original tissues. Statistical indicated DON exposure significantly inhibited organoid formation efficiency, well proliferation activity cells. RNA-seq Western blotting further revealed induces inhibiting PI3K/AKT/GSK3β/β-catenin signaling pathway. Our study provides novel example application studies reveals pathway involved DON-induced sheep, which great significance improving mitigation strategies DON.

Language: Английский

Citations

1
Novel lactobacillus consortium for effective zearalenone adsorption and biodegradation DOI
Bilal Murtaza, Lili Wang, Xiaoyu Li

et al.

International Biodeterioration & Biodegradation, Journal Year: 2024, Volume and Issue: 194, P. 105889 - 105889

Published: Aug. 18, 2024

Language: Английский

Citations

5
Probiotic Bacteria as a Green Solution for Mitigating Zearalenone Toxicity and Pollution DOI
Bilal Murtaza, Hongyang Ren,

Guo Ling-ling

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105593 - 105593

Published: Nov. 1, 2024

Language: Английский

Citations

1
Curcumin Attenuates Fumonisin B1-Induced Cell Apoptosis by Upregulating Mir-1249 Expression to Inhibit the Ire1/Mkk7/Jnk/Caspase3 DOI
Jia Chen,

yiting liao,

yuhang yang

et al.

Published: Jan. 1, 2024

Fumonisin B1 (FB1) is a toxic metabolite produced by fungi of the Fusarium genus. FB1 common contaminant grains and their derived feed products, posing global concerns for environmental pollution food safety. Curcumin (Cur), natural polyphenolic compound, has anti-inflammatory, antioxidant, free radical scavenging properties. Although studies have explored apoptotic mechanisms FB1, underlying mitigation FB1-induced toxicity Cur are not fully understood, limiting its potential application as novel additive to prevent toxicity. In this study, porcine kidney cells (PK-15) were used experimental model, utilizing mRNA miRNA transcriptome technologies. The results revealed that upregulated miR-1249 inhibits target gene Ern1 in PK-15 cells, thereby suppressing IRE1/MKK7/JNK/CASPASE3 endoplasmic reticulum (ER) stress pathway alleviating cell apoptosis. Cell transfection experiments confirmed effectively attenuated apoptosis induced ER following with inhibitor. Similarly, mimic alleviated cells. findings indicate mitigates significantly reduces damage

Language: Английский

Citations

0
Triclosan Induces Neurodevelopmental Toxicity Mediated by Circrna266/Mir-214 Regulatory Networks in Larval Zebrafish DOI
Huili Wang, Zejun Wang, Xiaowen Han

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Gene recognition and role of foodomics in mycotoxin control: A review DOI Creative Commons
U. Samarajeewa

Deleted Journal, Journal Year: 2024, Volume and Issue: 3(1), P. 1857 - 1857

Published: Dec. 9, 2024

Since recognition of toxic and carcinogenic aflatoxins in Brazilian groundnut meal 1960, much research has been done to prevent detoxify foods feeds, identifying a variety methods. The expanded other mycotoxins. biotic abiotic factors favoring mycotoxin contaminations have understood through experiments under laboratory conditions analysis field data. However, many gaps remain the knowledge on control at molecular level that may be useful addressing mycotoxigenic hazards. Recognition responsible genes hosts fungi omics methods applying genomics, transcriptomics, proteomics, metabolomics understand biosynthesis open new avenues interact with plant-fungi-bacteria cross-talks, apply regulatory mechanisms biosynthesis, explore checks controls biosynthesis. is expected generate probable biological eliminate foods. current requires application achieve deeper understanding, aiming for next-generation technologies. This review examines aflatoxins, fusarium toxins, patulin host-fungi interactions level.

Language: Английский

Citations

0