Lithium Coupled with C6-Carboxyl Improves the Efficacy of Oligoguluronate in DSS-Induced Ulcerative Colitis in C57BL/6J Mice DOI Creative Commons
Jiayi Li,

Meng Shao,

Hao Liu

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(12), P. 573 - 573

Published: Dec. 21, 2024

Oligoguluronate lithium (OGLi) was prepared for the purpose of enhancing anti-ulcerative colitis (UC) activities OG, in which (Li+) is coupled with C6-carboxyl G residue. The therapeutic effects OGLi on dextran sulfate (DSS)-induced UC mice were investigated, and oligoguluronate sodium (OGNa) carbonate (LC) used as contrasts. OGLi, OGNa LC treatment studied by monitoring body weight change evaluating colon length, disease activity index (DAI), histopathological examination gut microbiota regulation. results showed that compared LC, significantly reduced clinical symptoms changes associated acute model. It worth noting changed characteristics DSS-treated corrected typical dysbacteriosis DSS-induced UC. This intervention resulted increasing abundance norank_f_Muribaculaceae Ileibacterium spp. while reducing levels Escherichia-Shigella Romboutsia could increase diversity intestinal microorganisms short term. All these discoveries demonstrate collaboratively enhances anti-UC efficacy will help to create OG-based drugs

Language: Английский

Unveiling polysaccharides of Houttuynia cordata Thunb.: Extraction, purification, structure, bioactivities, and structure–activity relationships DOI
Shiyong Gao,

Weiya Wang,

Jianwen Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156436 - 156436

Published: Jan. 1, 2025

Language: Английский

Citations

4
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata DOI
Xu We, Xuejian Li,

Yu-Sen Zhong

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123381 - 123381

Published: Feb. 14, 2025

Language: Английский

Citations

2
Physicochemical Properties, Techno-functional Attributes, and Molecular Correlations of Fractionated Ulva prolifera Polysaccharides DOI Creative Commons
Zhen Cao, Huatian Wang, Tao Feng

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117396 - 117396

Published: Jan. 1, 2025

Language: Английский

Citations

0
Fermented Porphyra haitanensis polysaccharides inhibit the degranulation of mast cell and passive cutaneous anaphylaxis DOI
Zhen Lei Cheng,

S.F Wang,

Ling-Ying Li

et al.

Food & medicine homology., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A review on polysaccharide-based tumor targeted drug nanodelivery systems DOI
Liangxing Tu,

Banghuai Xing,

Shenglin Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140820 - 140820

Published: Feb. 1, 2025

Language: Английский

Citations

0
Enzymatic Hydrolysates of κ-Carrageenan by κ-Carrageenase-Based Magnetic Cross-Linked Nanoflowers Confers Pancreatic Lipase Inhibition Activity DOI

Chun‐Hua Zhu,

Tao Hong,

Mingjing Mou

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

The immobilized κ-carrageenase MCNF was developed by synergistic integration of κ-carrageenase, calcium phosphate crystals, and magnetic nanoparticles. outperformed free in terms optimal temperature, thermostability (45–55 °C), stability (pH 6.0 12.0), storage stability. Furthermore, extremely reusable easy to separate from the reaction system. MCNF's enzymatic breakdown κ-carrageenan resulted a tetrasaccharide that competitively inhibited pancreatic lipase (PL). Fluorescence titration experiments showed altered microenvironment PL causing static bursting its intrinsic fluorescence. circular dichroism experiment demonstrated adding reduced α-helix content increased β-sheet PL's secondary structure. Molecular docking dynamics simulation research suggested could form stable complex with PL, entering hydrophobic cavity occupying active site, reducing catalytic activity. κ-Carrageenan inhibit making it promising therapeutic agent for obesity prevention treatment.

Language: Английский

Citations

0
Algal Active Ingredients and Their Involvement in Managing Diabetic Mellitus DOI Creative Commons
Aijun Tong,

Dengwei Wang,

Nan Jia

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 904 - 904

Published: Nov. 6, 2024

Diabetes mellitus (DM) is becoming increasingly prominent, posing a serious threat to human health. Its prevalence rising every year, and often affects young people. In the past few decades, research on marine algae has been recognized as major field of drug discovery. Seaweed active substances, including algal polysaccharides, polyphenols, unsaturated fatty acids, dietary fiber, have unique biological activities. This article reviews effects mechanisms types, structures, compositions seaweed inhibiting glucose lipid metabolism disorders, with focus inhibitory effect substances blood reduction. The aim provide basis for development substance hypoglycemic drugs.

Language: Английский

Citations

1
Lithium Coupled with C6-Carboxyl Improves the Efficacy of Oligoguluronate in DSS-Induced Ulcerative Colitis in C57BL/6J Mice DOI Creative Commons
Jiayi Li,

Meng Shao,

Hao Liu

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(12), P. 573 - 573

Published: Dec. 21, 2024

Oligoguluronate lithium (OGLi) was prepared for the purpose of enhancing anti-ulcerative colitis (UC) activities OG, in which (Li+) is coupled with C6-carboxyl G residue. The therapeutic effects OGLi on dextran sulfate (DSS)-induced UC mice were investigated, and oligoguluronate sodium (OGNa) carbonate (LC) used as contrasts. OGLi, OGNa LC treatment studied by monitoring body weight change evaluating colon length, disease activity index (DAI), histopathological examination gut microbiota regulation. results showed that compared LC, significantly reduced clinical symptoms changes associated acute model. It worth noting changed characteristics DSS-treated corrected typical dysbacteriosis DSS-induced UC. This intervention resulted increasing abundance norank_f_Muribaculaceae Ileibacterium spp. while reducing levels Escherichia-Shigella Romboutsia could increase diversity intestinal microorganisms short term. All these discoveries demonstrate collaboratively enhances anti-UC efficacy will help to create OG-based drugs

Language: Английский

Citations

0