SIRT1 Regulates Fumonisin B1-Induced LMH Cell PANoptosis and Antagonism of Lycopene
Xueqi Wang,
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Yuan‐Hang Chang,
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Xiaochun Wang
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et al.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Mycotoxin
contamination
is
a
universal
agricultural
problem
and
critical
health
issue.
Fumonisin
B1
(FB1)
one
of
the
most
toxic
extensive
fumonisins
that
exist
in
various
agro-products
foods.
Lycopene
(LYC),
as
natural
carotenoid,
becoming
increasingly
favored
owing
to
its
oxidation
resistance.
Here,
we
aim
explore
mechanism
FB1-induced
hepatotoxicity
antagonism
LYC.
In
this
study,
our
findings
indicated
FB1
induced
mitochondrial
structure
damage
loss
function
chicken
hepatocytes.
Furthermore,
upregulated
expression
PANoptosis-related
signal
molecules.
also
reduced
levels
SIRT1
Ac-FOXO1
protein
expression,
which
then
inhibited
mitophagy.
However,
LYC
relieved
these
alterations.
Most
importantly,
knockdown
protective
effects
PANoptosis.
Our
study
provides
evidence
for
role
mycotoxin-induced
hepatocyte
injury
points
potential
target
liver
protection.
Language: Английский
Advancements in small molecule fluorescent probes for the detection of formaldehyde in environmental and food samples: A comprehensive review
Pengfei Wang,
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Minggui Gong,
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Ru‐Song Zhao
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et al.
Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 144041 - 144041
Published: March 1, 2025
Language: Английский
Research on the Evolutionary Game of Quality Governance of Geographical Indication Agricultural Products in China: From the Perspective of Industry Self-Governance
Zhao Guan-bing,
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Kuijian Zhan
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Sustainability,
Journal Year:
2025,
Volume and Issue:
17(8), P. 3414 - 3414
Published: April 11, 2025
Clarifying
stakeholder
demands
and
establishing
an
efficient
quality
governance
system
are
key
to
geographical
indication
development.
Current
frameworks
focus
on
government
oversight,
neglecting
industry
self-governance
through
associations.
A
four-party
evolutionary
game
model—production
organizations,
governments,
associations,
consumers—was
developed
explore
the
impact
of
quality.
Results
show
association-led
reduces
burdens
improves
efficiency.
Its
success
depends
support
fair
interest
distribution.
Additionally,
exhibits
two
optimal
equilibrium
points
at
different
stages
Even
under
relatively
relaxed
supervision
by
local
remains
functional
during
mature
development
phase.
Lastly,
a
reputation
mechanism
incorporating
consumer
participation
can
effectively
shape
decision-making
processes
production
while
costs
associated
with
complaints
play
critical
role
in
influencing
strategy
choices.
Language: Английский