Association between oral microbiome and breast cancer in the east Asian population: A Mendelian randomization and case–control study

Thoracic Cancer, Journal Year: 2024, Volume and Issue: 15(12), P. 974 - 986

Published: March 14, 2024

Abstract Background The causal relationship between breast cancer (BC) and the oral microbiome remains unclear. In this case–control study, using two‐sample Mendelian randomization (MR), we thoroughly explored BC in East Asian population. Methods Genetic summary data related to microbiota were collected from genome‐wide association studies involving participants of descent. MR estimates generated by conducting various analyses. Sequencing a study used verify validity these findings. Results analysis revealed that 30 tongue 37 salivary bacterial species significantly associated with BC. Interestingly, both microbiomes, observed effect six genera, namely, Aggregatibacter , Streptococcus Prevotella Haemophilus Lachnospiraceae Oribacterium Solobacterium on Our findings suggest differences specific bacteria patients healthy controls. Moreover, sequencing confirmed results, demonstrating compared control group, group had higher relative abundance Pasteurellaceae Streptococcaceae but lower Bacteroidaceae . Conclusions suggests exerts causative risk, supported study. future, should be undertaken comprehensively understand complex interaction mechanisms

Language: Английский

Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3040 - 3040

Published: Aug. 31, 2024

Cumulative evidence attests to the essential roles of commensal microbes in physiology hosts. Although microbiome has been a major research subject since time Luis Pasteur and William Russell over 140 years ago, recent findings that certain intracellular bacteria contribute pathophysiology healthy vs. diseased tissues have brought field new era investigation. Particularly, breast cancer research, breast-tumor-resident are now deemed be players tumor initiation progression. This is resurrection Russel's bacterial cause theory, which was fact abandoned 100 ago. review will introduce some exemplify carcinogenesis metastasis provide mechanistic explanations for these phenomena. Such information would able justify utility as biomarkers disease progression therapeutic targets.

Language: Английский

Clinical Relevance and Drug Modulation of PPAR Signaling Pathway in Triple‐Negative Breast Cancer: A Comprehensive Analysis

PPAR Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Triple‐negative breast cancer (TNBC) is highly heterogeneous and poses a significant medical challenge due to limited treatment options poor outcomes. Peroxisome proliferator‐activated receptors (PPARs) play crucial role in regulating metabolism cell fate. While the association between PPAR signal human cancers has been topic of concern, its specific relationship with TNBC remains unclear. Integrated analysis large published datasets from clinical cohorts lines through databases proven be powerful essential approach for understanding uncovering new molecular targets. Here, we conducted comprehensive study investigating relevance drug modulation signaling pathway TNBC, using data The Cancer Genome Atlas (TCGA) patients Genomics Drug Sensitivity (GDSC) lines, along perturbation information Connectivity Map (CMap). In TCGA‐TNBC cohort, higher activity was not associated stage, prognosis, tumor mutational burden, microsatellite instability, homologous recombination deficiency, stemness, or proliferation status. However, it linked older age; an elevated rate piccolo presynaptic cytomatrix protein (PCLO) mutations; oncogenic transduction involving MAPK, Ras, PI3K‐Akt pathways. Additionally, influenced biological pathways including fatty acid metabolism, AMPK signaling, ferroptosis. Strikingly, appeared promote formation antitumor immune microbial microenvironment. GDSC‐TNBC cells, nevertheless, seemed incur chemoresistance. Furthermore, identified batch potential compounds that can regulate pathway. Lastly, our experimental validation demonstrated ability histone deacetylase (HDAC) inhibitor chidamide activate cells. conclusion, likely pleiotropic effects TNBC. These preliminary but interesting findings enhance played by provide insights into heterogeneity driven

Language: Английский