Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
174, P. 112137 - 112137
Published: March 9, 2023
The
strong
interest
shown
in
the
study
of
causes
aging
recent
decades
has
uncovered
many
mechanisms
that
could
contribute
to
rate
aging.
These
include
mitochondrial
ROS
production,
DNA
modification
and
repair,
lipid
peroxidation-induced
membrane
fatty
acid
unsaturation,
autophagy,
telomere
shortening
rate,
apoptosis,
proteostasis,
senescent
cells,
most
likely
there
are
others
waiting
be
discovered.
However,
all
these
well-known
work
only
or
mainly
at
cellular
level.
Although
it
is
known
organs
within
a
single
individual
do
not
age
exactly
same
well-defined
species
longevity.
Therefore,
loose
coordination
among
different
cells
tissues
needed
ensure
lifespan.
In
this
article
we
focus
on
less
extracellular,
systemic,
whole
organism
level
loosely
coordinate
keep
margins
its
We
discuss
heterochronic
parabiosis
experiments,
systemic
factors
distributed
through
vascular
system
like
DAMPs,
fragments,
TF-like
proteins,
inflammaging,
as
well
epigenetic
proposed
clocks
situated
levels
organization
from
brain.
interorgan
systems
can
help
determine
longevity
further
adaptation
ecosystem.
Journal of Occupational and Environmental Medicine,
Journal Year:
2023,
Volume and Issue:
65(5), P. e312 - e318
Published: Feb. 14, 2023
Objective
The
aim
of
the
study
is
to
examine
associations
between
years
firefighting
service
and
eight
chronological
age-adjusted
measures
blood
leukocyte
epigenetic
age
acceleration:
Horvath,
Hannum,
SkinBloodClock,
Intrinsic,
Extrinsic,
PhenoAge,
GrimAge,
DNAm
telomere
length.
Methods
used
a
repeated
analysis
data
from
379
incumbent
firefighters
career
departments
100
recruit
two
departments,
across
United
States.
Results
Incumbent
had
on
average
greater
acceleration
compared
with
firefighters,
potentially
due
cumulative
effect
occupational
exposures.
However,
among
additional
were
associated
deceleration,
particularly
for
strong
predictor
mortality.
Conclusions
Long-term
studies
more
specific
exposure
classification
are
needed
better
understand
relationship
aging
biomarkers.
Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
174, P. 112137 - 112137
Published: March 9, 2023
The
strong
interest
shown
in
the
study
of
causes
aging
recent
decades
has
uncovered
many
mechanisms
that
could
contribute
to
rate
aging.
These
include
mitochondrial
ROS
production,
DNA
modification
and
repair,
lipid
peroxidation-induced
membrane
fatty
acid
unsaturation,
autophagy,
telomere
shortening
rate,
apoptosis,
proteostasis,
senescent
cells,
most
likely
there
are
others
waiting
be
discovered.
However,
all
these
well-known
work
only
or
mainly
at
cellular
level.
Although
it
is
known
organs
within
a
single
individual
do
not
age
exactly
same
well-defined
species
longevity.
Therefore,
loose
coordination
among
different
cells
tissues
needed
ensure
lifespan.
In
this
article
we
focus
on
less
extracellular,
systemic,
whole
organism
level
loosely
coordinate
keep
margins
its
We
discuss
heterochronic
parabiosis
experiments,
systemic
factors
distributed
through
vascular
system
like
DAMPs,
fragments,
TF-like
proteins,
inflammaging,
as
well
epigenetic
proposed
clocks
situated
levels
organization
from
brain.
interorgan
systems
can
help
determine
longevity
further
adaptation
ecosystem.
