Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer DOI Creative Commons
Zhihan Wang, Pan Gao, Kai Guo

et al.

JCI Insight, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Colon cancer affects people of all ages. However, its frequency, as well the related morbidity and mortality, are high among older adults. The complex physiological changes in aging gut substantially limit development therapies. Here, we identify a unique intestinal microenvironment that is linked with an increased risk colon Our findings show markedly influences persistent fucosylation apical surfaces epithelial cells, which results favorable environment for tumor growth. Furthermore, our shed light on importance host-commensal interaction, facilitates dysregulation promotes growth get older. We analyzed colonic microbial populations at species level to find associated could contribute cancer. Analysis scRNAseq from previous publication datasets identifies distinct cell subtypes involved dysregulated Overall, study provides compelling evidence excessive cancer, age-related increase vulnerability dysbiosis diversity metabolic homeostasis mice dysregulate levels age.

Language: Английский

Association between the Planetary Health Diet Index and biological aging among the U.S. population DOI Creative Commons

Shaoqun Huang,

H. M. Hu,

Hongyang Gong

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 22, 2024

Background The Planetary Health Diet (PHD) is a novel dietary pattern proposed by the EAT-Lancet Commission in 2019, yet limited study has investigated anti-aging effects of PHD to date. Objectives This aimed explore association between adherence PHD, as quantified Index (PHDI), and biological aging American populations. Methods Data were obtained from National Nutrition Examination Survey (NHANES) for 1999–2018. Food consumption information was relied on two 24-h diet recall questionnaires. condition comprehensively assessed four markers, including phenotypic age, telomere length, klotho concentration. Weighted multivariate linear models, restricted cubic spline (RCS), subgroup analysis subsequently carried out evaluate influence PHDI aging. Results 44,925 participants with complete data finally enrolled our study. fully adjusted models showed decreased 0.20 years age [−0.20 (−0.31, −0.10)] declined 0.54 [−0.54 (−0.69, −0.38)] correlated per 10 scores increment. Klotho concentration [6.2 (1.0, 11.0)] positively related PHDI. In Model 2, length increased 0.02 bp every 10-point rise Besides, RCS results exhibited curvilinear relationship indicators. Conclusion Our explored significant correlation aging, indicating that may prevent

Language: Английский

Citations

2
The role of autoantibodies in bridging obesity, aging, and immunosenescence DOI Creative Commons
Taylor R. Valentino, Nan Chen, Priya Makhijani

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 30, 2024

Abstract Antibodies are essential to immune homeostasis due their roles in neutralizing pathogenic agents. However, failures central and peripheral checkpoints that eliminate autoreactive B cells can undermine self-tolerance generate autoantibodies mistakenly target self-antigens, leading inflammation autoimmune diseases. While well-studied some communicable diseases, chronic conditions, such as obesity aging, less understood. Obesity aging share similar aspects of dysfunction, diminished humoral responses heightened inflammation, which disrupt tolerance foster autoantigen production, thus giving rise autoantibodies. In return, these events may also contribute the pathophysiology associated disorders linked development immunosenescence, an age-related decline function heightens vulnerability infections, loss self-tolerance. Furthermore, cumulative exposure antigens cellular debris during perpetuates pro-inflammatory pathways, linking immunosenescence with other hallmarks, proteostasis mitochondrial dysfunction. This review examines mechanisms driving autoantibody generation discusses key putative antigenic targets across conditions. We explore therapeutic potential emerging approaches, CAR-T/CAAR-T therapies, vaccines, BiTEs, tackle autoimmune-related conditions obesity.

Language: Английский

Citations

2
Gut microb-aging and its relevance to frailty aging DOI Creative Commons
Guillaume Le Cosquer, Nathalie Vergnolle, Jean‐Paul Motta

et al.

Microbes and Infection, Journal Year: 2024, Volume and Issue: 26(3), P. 105309 - 105309

Published: Feb. 4, 2024

This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations microbiota's taxonomy metabolism, as well with concepts of ecological resilience, pathobionts emergence, biogeography. examine microb-aging interconnected body organs, emphasizing bidirectional relationship 'inflammaging'. Finally, we discuss how targeting could improve screening, diagnostic, therapeutic approaches geriatrics.

Language: Английский

Citations

2
Disentangling the age-related manner in the associations between gut microbiome and women’s health: a multi-cohort microbiome study DOI Creative Commons
Chao Dong,

Quanquan Guan,

Wei Xu

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Dec. 7, 2023

Women's health encompasses life-course healthcare, and mounting evidence emphasizes the pivotal contribution of gut microbiota. Therefore, understanding temporal dynamics microbiota how age influences disease-gut associations is essential for improving women's health. By analyzing metagenomic data from 3625 healthy women, we revealed significant effects on age-dependent patterns in microbial features, such as relative abundance, Shannon index, network properties. Additionally, declining trends predictive accuracy groups were shown using iterative sub-sampling based random forest (ISSRF) model. Age-specific species markers also identified, many which shared across groups. To investigate influence associations, 681 women with various disease conditions 491 matched controls collected. A substantial proportion inflammatory bowel (IBD), type 2 diabetes (T2D), atherosclerotic cardiovascular (ACVD), impaired glucose tolerance (IGT) differed abundance groups, age-specific markers. Besides, microbiota-based probabilities IBD ACVD positively correlated age. Furthermore, specificity was explored ISSRF Associations between age-specific, reduced stability childhood adolescence, possibly due to decrease effect size patients controls. Our findings provided valuable insights into promoting aging developing personalized healthcare strategies women.

Language: Английский

Citations

4
Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer DOI Creative Commons
Zhihan Wang, Pan Gao, Kai Guo

et al.

JCI Insight, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Colon cancer affects people of all ages. However, its frequency, as well the related morbidity and mortality, are high among older adults. The complex physiological changes in aging gut substantially limit development therapies. Here, we identify a unique intestinal microenvironment that is linked with an increased risk colon Our findings show markedly influences persistent fucosylation apical surfaces epithelial cells, which results favorable environment for tumor growth. Furthermore, our shed light on importance host-commensal interaction, facilitates dysregulation promotes growth get older. We analyzed colonic microbial populations at species level to find associated could contribute cancer. Analysis scRNAseq from previous publication datasets identifies distinct cell subtypes involved dysregulated Overall, study provides compelling evidence excessive cancer, age-related increase vulnerability dysbiosis diversity metabolic homeostasis mice dysregulate levels age.

Language: Английский

Citations

1