Microbiology and Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
ABSTRACT
Hepatitis
B
virus
(HBV)
causes
chronic
hepatitis
B,
which
can
progress
to
liver
cirrhosis
and
hepatocellular
carcinoma.
HBV
has
complex
interactions
with
various
cell
organelles
proteins
that
ensure
effective
progeny
production.
We
previously
reported
a
mitochondrial
protein,
TIMM29,
should
regulate
the
life
cycle
through
preS1
protein.
Here,
we
established
Halo‐TIMM29wt‐,
Halo‐TIMM29:∆99–192‐,
Halo‐TIMM29:92–194‐expressing
cells
using
TIMM29‐knockout
HB611
(TIMM29KO/HB611)
cells,
stably
HBV‐producing
line
based
on
Huh6
cells.
found
antigen
expression
replication
were
downregulated
in
expressing
full‐length
but
not
those
TIMM29
deletion
mutants.
On
other
hand,
case
of
C4
(TIMM29KO/C4),
is
human
NTCP‐expressing
HepG2
competent
for
infection
amplification,
these
phenomena
reproduced,
except
(Halo‐TIMM29wt)‐expressing
Using
gene
microarrays,
identified
downregulation
ARRDC3
BASP1
TIMM29KO/HB611
TIMM29KO/C4.
It
was
suggested
localized
at
inner
membrane
served
as
signaling
hub,
orchestrating
activation
restrict
transcription.
The
mutants
TIMM29KO/C4
dependent
preS1‐binding
region
(amino
acids
99–189).
In
contrast,
varied
according
type,
indicating
additional
regulatory
mechanisms.
Thus,
this
study
significantly
advance
our
understanding
TIMM29‐mediated
inhibition
amplification
lead
improvements
antiviral
strategies
therapeutic
interventions
against
HBV.
Basic Research in Cardiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 14, 2024
Abstract
Cardiovascular
diseases
and
cancer
are
the
leading
causes
of
death
in
Western
world
share
common
risk
factors.
Reduced
cardiorespiratory
fitness
(CRF)
is
a
major
determinant
cardiovascular
morbidity
survival.
In
this
review
we
discuss
cancer-
induced
disturbances
parenchymal,
cellular,
mitochondrial
function,
which
limit
CRF
may
be
antagonized
attenuated
through
exercise
training.
We
show
impact
on
survival
its
attenuating
effects
cardiotoxicity
cancer-related
treatment.
Tailored
programs
not
yet
available
for
each
tumor
entity
as
several
trials
were
performed
heterogeneous
populations
without
adequate
cardiopulmonary
testing
(CPET)
prior
to
prescription
with
wide
variation
modalities.
There
emerging
evidence
that
crucial
pillar
treatment
tool
mitigate
cardiotoxic
effects.
modalities
aerobic
resistance
training
their
potential
improve
patients
provide
an
example
periodization
model
cancer.
Journal of Neuroinflammation,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Feb. 6, 2024
Abstract
Stroke
is
a
clinical
syndrome
characterized
by
an
acute,
focal
neurological
deficit,
primarily
caused
the
occlusion
or
rupture
of
cerebral
blood
vessels.
In
stroke,
neuroinflammation
emerges
as
pivotal
event
contributing
to
neuronal
cell
death.
The
occurrence
and
progression
entail
intricate
processes,
prominently
featuring
mitochondrial
dysfunction
adaptive
responses.
Mitochondria,
double
membrane-bound
organelle
are
recognized
“energy
workshop”
body.
Brain
particularly
vulnerable
disturbances
due
its
high
energy
demands
from
mitochondria-related
production.
interplay
between
mitochondria
plays
significant
role
in
pathogenesis
stroke.
biological
pathological
consequences
resulting
stress
have
substantial
implications
for
function.
Mitochondrial
serves
mechanism
aimed
at
mitigating
induced
import
misfolded
proteins,
which
occurs
response
This
involves
reduction
protein
accumulation
overall
synthesis.
influence
on
state
stroke
underscored
capacity
interact
with
neuroinflammation.
impact
varies
according
severity.
Moderate
can
bolster
cellular
defenses,
enabling
cells
better
withstand
detrimental
stressors.
contrast,
sustained
excessive
detrimentally
affects
tissue
integrity.
relationship
depends
degree
present.
Understanding
instrumental
excavating
novel
treatment
review
aims
provide
evaluation
cross-talk
within
context
We
aim
reveal
how
environment
Seminars in Immunology,
Journal Year:
2023,
Volume and Issue:
69, P. 101808 - 101808
Published: July 18, 2023
Mitochondrial
dysfunction
is
a
hallmark
of
aging
that
contributes
to
inflammaging.
It
characterized
by
alterations
the
mitochondrial
DNA,
reduced
respiratory
capacity,
decreased
membrane
potential
and
increased
reactive
oxygen
species
production.
These
primary
disrupt
other
interconnected
important
mitochondrial-related
processes
such
as
metabolism,
dynamics
biogenesis,
mitophagy,
calcium
homeostasis
or
apoptosis.
In
this
review,
we
gather
current
knowledge
about
different
which
are
altered
during
aging,
with
special
focus
on
their
contribution
age-associated
T
cell
Mitochondrion,
Journal Year:
2023,
Volume and Issue:
72, P. 84 - 101
Published: Aug. 13, 2023
Over
65
million
people
suffer
from
recurrent,
unprovoked
seizures.
The
lack
of
validated
biomarkers
specific
for
myriad
forms
epilepsy
makes
diagnosis
challenging.
Diagnosis
and
monitoring
childhood
add
to
the
need
non-invasive
biomarkers,
especially
when
evaluating
antiseizure
medications.
Although
underlying
mechanisms
epileptogenesis
are
not
fully
understood,
evidence
mitochondrial
involvement
is
substantial.
Seizures
affect
35%-60%
patients
diagnosed
with
diseases.
Mitochondrial
dysfunction
pathophysiological
in
various
epilepsies,
including
those
non-mitochondrial
origin.
Decreased
ATP
production
caused
by
malfunctioning
brain
cell
mitochondria
leads
altered
neuronal
bioenergetics,
metabolism
neurological
complications,
Iron-dependent
lipid
peroxidation
initiates
ferroptosis,
a
death
pathway
that
aligns
morphology
found
neurodegenerative
diseases
(NDDs).
Studies
mouse
genetic
models
seizure
phenotypes
where
function
an
essential
selenoprotein
(GPX4)
targeted
suggest
roles
ferroptosis
epilepsy.
GPX4
pivotal
NDDs,
selenium
protects
interneurons
ferroptosis.
Selenium
central
nervous
system
micronutrient
trace
element.
Low
serum
concentrations
other
elements
minerals,
iron,
noted
diagnosing
supplements
alleviate
intractable
seizures
children
reduced
GPX
activity.
Copper
cuproptosis,
like
iron
link
NDDs.
Connecting
these
mechanistic
pathways
selenoproteins
provides
new
insights
into
treating
seizures,
pointing
using
medicines
prodrugs
lipoic
acid
treat
potential
alternative
therapeutic
approaches
transcranial
magnetic
stimulation
(transcranial),
photobiomodulation
vagus
nerve
stimulation.
Diabetes & Metabolism Journal,
Journal Year:
2024,
Volume and Issue:
48(1), P. 1 - 18
Published: Jan. 4, 2024
Mitochondrial
stress
and
the
dysregulated
mitochondrial
unfolded
protein
response
(UPR<sup>mt</sup>)
are
linked
to
various
diseases,
including
metabolic
disorders,
neurodegenerative
cancer.
Mitokines,
signaling
molecules
released
by
UPR<sup>mt</sup>,
crucial
mediators
of
inter-organ
communication
influence
systemic
physiological
processes.
In
this
review,
we
provide
a
comprehensive
overview
mitokines,
their
regulation
exercise
lifestyle
interventions
implications
for
diseases.
The
endocrine
actions
mitokines
related
adaptations
highlighted,
specifically
broad
functions
fibroblast
growth
factor
21
differentiation
15,
as
well
specific
in
regulating
inter-tissue
homeostasis.
Finally,
discuss
potential
genetic
reduce
hazards
associated
with
mitokine
preserve
an
equilibrium
stress-induced
responses.
This
review
provides
valuable
insights
into
mechanisms
underlying
health
disease
exploring
interactions
regulation,
which
will
facilitate
development
targeted
therapies
personalized
improve
outcomes
quality
life.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 26, 2024
Abstract
Type
2
diabetes
(T2D)
can
cause
severe
cardiac
complications
at
functional,
histologic
and
molecular
levels.
These
pathological
could
be
mediated
by
ATP-releasing
channels
such
as
Panx1
ATP
receptors,
in
particular
P2X7.
The
aim
of
our
study
was
to
investigate
the
effect
high-intensity
interval
training
(HIIT)
on
T2D-induced
histopathological
levels,
with
a
focus
channels.
48
male
Wistar
rats
age
8
weeks
were
randomly
allocated
into
four
groups:
control
(Con),
Diabetes
(T2D),
Training
(TR),
+
(T2D
TR).
T2D
induced
high-fat
diet
plus
low
dose
(35
mg/kg)
STZ
administration.
Rats
TR
groups
underwent
an
8-weeks
program
involving
intervals
ranging
from
80
100%
their
maximum
running
speed
(Vmax),
4–10
per
session.
Protein
expression
Interleukin
1β
(IL1β),
10
(IL-10),
Pannexin
1
(Panx1),
P2X7R
(purinergic
P2X
receptor
7),
NLRP1
(NLR
Family
Pyrin
Domain
Containing
1),
BAX,
Bcl2
measured
heart
tissue.
Additionally,
we
assessed
function,
changes,
well
insulin
resistance
using
homeostasis
model
assessment
(HOMA-IR).
In
contrast
group,
HIIT
led
increased
protein
IL-10
heart.
It
also
resulted
improvements
systolic
diastolic
blood
pressures,
rate,
±
dp/dt
(maximum
minimum
changes
left
ventricular
pressure),
while
reducing
IL-1β,
Panx1,
P2X7R,
NLRP1,
BAX
levels
Furthermore,
pressure
(LVDP)
reduced
(
P
≤
0.05).
Moreover,
lesion
scores
but
decreased
HIIT,
along
reduction
fibrosis
percentage
results
this
suggest
that
cardioprotective
effects
diabetic
may
modulation
This
lead
inflammation
apoptosis,
improve
attenuate
injury
fibrosis.
The Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
602(4), P. 545 - 568
Published: Jan. 9, 2024
Abstract
Exercise
is
a
powerful
non‐pharmacological
intervention
for
the
treatment
and
prevention
of
numerous
chronic
diseases.
Contracting
skeletal
muscles
provoke
widespread
perturbations
in
cells,
tissues
organs,
which
stimulate
multiple
integrated
adaptations
that
ultimately
contribute
to
many
health
benefits
associated
with
regular
exercise.
Despite
much
research,
molecular
mechanisms
driving
such
changes
are
not
completely
resolved.
Technological
advancements
beginning
early
1960s
have
opened
new
avenues
explore
responsible
beneficial
This
has
led
increased
research
into
role
small
peptides
(<100
amino
acids)
mitochondrially
derived
metabolism
disease,
including
those
coded
within
open
reading
frames
(sORFs;
coding
sequences
encode
peptides).
Recently,
it
been
hypothesized
sORF‐encoded
other
play
significant
roles
as
exercise‐sensitive
exercise‐induced
physiological
adaptation.
In
this
review,
we
highlight
discovery
newly
discovered
involved
metabolism,
specific
emphasis
on
their
functions
metabolic
light
few
studies
available,
also
present
data
how
both
single
exercise
sessions
training
affect
expression
peptides.
Finally,
outline
questions
await
investigation
regarding
various
diseases,
addition
adaptations,
future
studies.
image
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
53(6)
Published: April 24, 2024
Fibroblast
growth
factor
(FGF)21
is
a
peptide
hormone
that
improves
mitochondrial
function
and
energy
metabolism,
the
deficiency
of
its
co‑receptor
β‑klotho
(KLB)
causes
decreased
FGF21
sensitivity.
The
present
study
examined
whether
cardiac
delivery
plasmids
containing
KLB
gene
via
ultrasound‑targeted
microbubble
destruction
(UTMD)
enhances
efficacy
against
heart
failure
post‑acute
myocardial
infarction
(AMI).
For
this
purpose,
levels
in
patients
rats
with
dysfunction
post‑infarction
were
determined
using
ELISA.
Sprague‑Dawley
received
3X
UTMD‑mediated
KLB@cationic
microbubbles
(KLB@CMBs)
1
week
following
induction
AMI.
Echocardiography,
histopathology
biochemical
analysis
performed
at
4
weeks
results
revealed
had
higher
serum
than
healthy
controls.
However,
downstream
signal,
KLB,
but
not
α‑klotho,
was
reduced
tissues
As
expected,
treatment
did
substantially
attenuate
remodeling
post‑infarction.
It
found
receptors
KLB
may
result
insensitivity
to
treatment.
In
vivo,
UTMD
technology‑mediated
KLB@CMBs
significantly
enhanced
effects
administration
on
infarction.
by
attenuated
impairment
oxidative
stress
activating
nuclear
erythroid
2‑related
2
signals.
On
whole,
demonstrates
optimizes
cardioprotective
therapy
adverse
remodeling.
appears
promising
interdisciplinary
approach
which
improve
post‑myocardial
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 15, 2024
Introduction
Growth
differentiation
factor
15
(GDF-15)
was
originally
described
as
a
stress-induced
cytokine,
and
biomarker
of
aging
cardiovascular
diseases.
We
hypothesized
that
circulating
GDF-15
would
be
associated
with
COVID-19
disease
severity.
Herein,
we
explored
this
hypothesis
in
large
cohort
patients.
Methods
Blood
samples
were
collected
from
926
adult
patients
285
hospitalized
controls
the
Biobanque
Québécoise
de
la
(BQC19).
severity
graded
according
to
WHO
criteria.
SOMAscan
proteomics
assay
performed
on
50µL
plasma.
ELISA
46
selected
participants
left-over
plasma
validate
differences
levels.
Statistical
analyses
conducted
using
GraphPad
Prism
9.0
SPSS.
P
values
<
0.01
considered
significant.
Results
Proteomics
showed
levels
higher
compared
controls.
increased
presenting
comorbidities
including
diabetes,
cancer,
chronic
obstructive
pulmonary
(COPD)
had
revealed
significant
elevation
until
30
days
after
hospitalization.
Plasma
correlated
older
age.
Moreover,
pro-inflammatory
cytokine
interleukin-6
(IL-6)
inflammation
marker
C-reactive
protein
(CRP)
well
soluble
its
putative
receptor
CD48.
No
association
established
between
anti-SARS-CoV-2
IgG
Conclusions
This
study
confirms
for
Clinical
evaluation
could
assist
identification
persons
at
high-risk
progressing
severe
disease,
thus
improving
patient
care.