Psychological and Mental Health in Graeco-Roman Egypt: Selected Disorders and Diseases DOI Open Access

N. Shalaby,

Mina Adeeb Ibrahim

International Academic Journal Faculty of Tourism and Hotel Management, Journal Year: 2023, Volume and Issue: 9(1), P. 31 - 70

Published: June 1, 2023

The publication of the ancient Egyptian medical papyri starting from 2nd half 19th century revealed their ingenuity in field medicine almost all its specialties; concern for mental and psychological health was on par with that physical health. Egyptians perfectly balanced work leisure, which had a positive impact health; overall wellbeing is largely reflected level civilizational superiority. Nevertheless, experiencing negative emotions, head injuries, or other problems inevitable, adversely individuals. This study deals selection disorders diseases (Depression, Epilepsy, Paraphilia, Dementia, Hysteria). It aims to tackle concept various methods treatment these diseases, whether magical approaches, Egypt during Graeco-Roman Period mutual influence Classical world.

Language: Английский

Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review) DOI Creative Commons
Pei Qin,

Ye Sun,

Liya Li

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(5)

Published: April 2, 2024

Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators neuroinflammation. In addition to providing energy cells, mitochondria also participate immunoinflammatory response disorders including Alzheimer's disease, Parkinson's multiple sclerosis epilepsy, by regulating processes such cell death inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, dynamics calcium homeostasis imbalance may underlying regulatory mechanisms for these diseases. Therefore, investigating related dysfunction result therapeutic strategies against chronic neurodegeneration. The present review summarizes neuroinflammatory diseases current treatment approaches that target

Language: Английский

Citations

15
Copper homeostasis and cuproptosis in central nervous system diseases DOI Creative Commons
Zhipeng Zhu, Min Song,

Jianxun Ren

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 20, 2024

Abstract Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array fundamental metabolic processes. The human body maintains relatively low concentration copper, which is mostly found in bones, liver, and brain. Despite its concentration, Cu plays crucial role as element progression pathogenesis central nervous system (CNS) diseases. Extensive studies have been conducted recent years on copper homeostasis copper-induced cell death CNS disorders, including glioma, Alzheimer’s disease, Amyotrophic lateral sclerosis, Huntington’s stroke. Cuproptosis, novel pathway distinct from apoptosis, necrosis, pyroptosis, ferroptosis, has identified potentially intricately linked pathogenic mechanisms underlying various Therefore, systematic review cuproptosis their relationship with disorders could deepen our understanding these In addition, it may provide new insights strategies treatment disorders.

Language: Английский

Citations

5
Recent advances in nanotherapy-based treatment of epilepsy DOI
Peng Chen, Shudong Wang, Heming Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114499 - 114499

Published: Jan. 6, 2025

Language: Английский

Citations

0
Mitochondria-targeting peptide SS-31 attenuates ferroptosis via inhibition of the p38 MAPK signaling pathway in the hippocampus of epileptic rats DOI
Xue Liu, Feiyu Wang,

Song Chi

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1836, P. 148882 - 148882

Published: March 21, 2024

Language: Английский

Citations

4
Insight into the Role of Ferroptosis in Epilepsy DOI Creative Commons
Li‐Min Huang, Haiyan Liu,

Songyan Liu

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(6), P. 113 - 113

Published: June 13, 2024

Excessively high or synchronized neuronal activity in the brain is underlying cause of epilepsy, a condition central nervous system. Epilepsy caused mostly by an imbalance inhibitory and excitatory neural networks. Recurrent prolonged seizures lead to death, which turn promotes epileptogenesis epileptic seizures. Ferrous ion-mediated cell death known as ferroptosis, due accumulation lipid peroxidation products resulting from compromise glutathione (GSH)-dependent antioxidant The pathophysiology epilepsy has been linked anomalies peroxidase 4 (GPX4)/GSH redox pathway, peroxidation, iron metabolism. Studies have shown that inhibiting ferroptosis may alleviate cognitive impairment decrease seizures, indicating it neuroprotective. With hope aiding development more novel approaches for management this research aimed examine role disease.

Language: Английский

Citations

4
The lactate metabolism and protein lactylation in epilepsy DOI Creative Commons
Xi Kuang, Shuang Chen,

Qingmei Ye

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 14, 2025

Protein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have linked to protein in brain tissue, which shown correlate with increased neuronal excitability. Ischemic stroke may promote glycolysis, leading lactate accumulation tissue. This heighten excitability by upregulating levels, potentially triggering post-stroke epilepsy. Although current clinical treatments for seizures advanced significantly, approximately 30% patients epilepsy remain unresponsive medication, and prevalence continues rise. study explores mechanisms epilepsy-associated death mediated metabolism lactylation. also examines potential histone deacetylase inhibitors alleviate modifying thereby offering fresh perspectives future research into pathogenesis treatment

Language: Английский

Citations

0
Therapeutic Approach to Epilepsy in Patients with Mitochondrial Diseases DOI Creative Commons
Jihoon Na, Young‐Mock Lee

Yonsei Medical Journal, Journal Year: 2025, Volume and Issue: 66

Published: Jan. 1, 2025

Mitochondrial diseases (MDs) are genetic disorders with diverse phenotypes that affect high-energy-demand organs, notably the central nervous system and muscles. Epilepsy is a common comorbidity, affecting 40%-60% of patients MDs significantly reducing their quality life. This review discusses different treatment modalities for epilepsy in MDs. Advances sequencing have identified specific mutations mitochondrial nuclear DNA, enabling more precise diagnoses tailored therapeutic strategies. Anti-seizure medications dietary interventions, such as ketogenic diets variants, been effective seizures improving function. Emerging treatments include gene therapy, transplantation, antioxidants EPI-743, which protect integrity improve neurological Additionally, therapies promote biogenesis, bezafibrate epicatechin, being explored potential to enhance proliferation energy production. Gene therapy aims correct defects underlying Techniques like replacement using viral vectors deliver functional genes shown promise preclinical studies. an emerging experimental technique, involves transferring healthy mitochondria into cells dysfunctional mitochondria. technique has demonstrated restore function metabolism models. Patient-derived induced pluripotent stem can model dysfunctions vitro, allowing testing various individual biochemical profiles. The future medicine promising, development targeted personalized strategies offering hope improved management prognosis epilepsy.

Language: Английский

Citations

0
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

Citations

0
Cordycepin Ameliorates Kainic Acid‐Induced HT22 Cell Neurotoxicity by Activating GPR120‐Mediated Mitophagy DOI Open Access

YONG-ZHI SAN,

Minghua Wang

Developmental Neurobiology, Journal Year: 2025, Volume and Issue: 85(2)

Published: Feb. 25, 2025

Mitophagy is important for normal neural activity. Epilepsy intimately linked to neurotoxicity due mitochondrial dysfunction. Cordycepin (Cor) has been shown exert neuroprotective effects. This study aims investigate whether Cor could mitigate in epilepsy by modulating mitophagy. In vitro, kainic acid (KA) was utilized induce cytotoxicity HT22 cell. Cell viability assessed using the CCK-8 assay, while cell damage evaluated through an LDH kit. Flow cytometry used assess apoptosis. The expressions of G protein-coupled receptor 120 (GPR120), apoptosis, and mitophagy-related proteins were analyzed western blot. Inflammatory factors oxidative stress levels examined kits. DCFH-DA staining applied observe cellular reactive oxygen species (ROS) levels. three-dimensional coordinates GPR120 retrieved from PDB database, molecular docking performed AutoDock. Immunofluorescence mitophagy level. significantly attenuated KA-induced injury inflammation, suppressing ROS Notably, ameliorated decrease level observed cells treated with KA. expression upregulated following KA treatment further elevated after adding Cor. bind GPR120. Interference reversed ameliorative effects on cells. Overall, alleviated neurotoxic stress. protective effect may be mediated GPR120-regulated

Language: Английский

Citations

0
The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review DOI Creative Commons
Zhixin Zhang, Zhiyu Zhang, Peng Liu

et al.

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Nov. 23, 2024

Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular pathways by altering cell membrane potentials, leading to beneficial biological effects such as anti-inflammatory neuroregenerative responses. This review compiles studies from PubMed up March 2024, investigating the impact of light at wavelengths ranging 620 1270 nm on ion channels. Out 330 articles screened, 19 met inclusion criteria. Research indicates PBM can directly affect various channels influencing neurotransmitter synthesis in neighboring cells, impacting receptors like glutamate acetylcholine, well potassium, sodium channels, transient receptor potential The diversity hampers comprehensive meta-analysis for evaluating treatment strategies effectively. systematic aims explore role optoelectronic signal transduction PBM, studying neurobiological mechanisms therapeutic significance However, lack uniformity current methods underscores necessity establishing standardized reliable approaches. promising neurotherapeutic approach with through its analyzes studies, revealing influence channel activity emphasizing need protocols.

Language: Английский

Citations

3