Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1085 - 1085
Published: July 6, 2023
Aging
attenuates
the
overall
responsiveness
of
immune
system
to
eradicate
pathogens.
The
increased
production
pro-inflammatory
cytokines
by
innate
cells
under
basal
conditions,
termed
inflammaging,
contributes
impaired
towards
pathogen-mediated
stimulation
and
limits
antigen-presenting
activity.
Adaptive
responses
are
attenuated
as
well
due
lowered
numbers
naïve
lymphocytes
their
antigen-specific
stimulation.
Additionally,
immunoregulatory
cell
types,
comprising
regulatory
T
myeloid-derived
suppressor
cells,
that
inhibit
activity
adaptive
elevated.
This
review
aims
summarize
our
knowledge
on
cellular
molecular
causes
immunosenescence
while
also
taking
into
account
senescence
effects
constitute
evasion
mechanisms
in
case
chronic
viral
infections
cancer.
For
tumor
therapy
numerous
nanoformulated
drugs
have
been
developed
overcome
poor
solubility
compounds
enable
cell-directed
delivery
order
restore
functions,
e.g.,
addressing
dysregulated
signaling
pathways.
Further,
nanovaccines
which
efficiently
address
mount
sustained
anti-tumor
clinically
evaluated.
senolytics
selectively
deplete
senescent
being
tested
a
number
clinical
trials.
Here
we
discuss
potential
use
such
improve
anti-aging
therapy.
American Journal of Respiratory Cell and Molecular Biology,
Journal Year:
2024,
Volume and Issue:
71(2), P. 229 - 241
Published: April 18, 2024
Aging
poses
a
global
public
health
challenge,
which
is
linked
to
the
rise
of
age-related
lung
diseases.
The
precise
understanding
molecular
and
genetic
changes
in
aging
that
elevate
risk
acute
chronic
diseases
remains
incomplete.
Alveolar
type
II
(AT2)
cells
are
stem
maintain
epithelial
homeostasis
repair
after
injury.
AT2
progenitor
function
decreases
with
aging.
maintenance
requires
niche
support
from
other
cell
types,
but
little
has
been
done
characterize
alveolar
alterations
niche.
To
systematically
profile
associated
age,
we
present
single-cell
transcriptional
atlas
comprising
nearly
half
million
healthy
lungs
human
subjects
spanning
various
ages,
sexes,
smoking
statuses.
Most
annotated
lineages
aged
exhibit
dysregulated
programs.
Specifically,
demonstrate
loss
identities,
heightened
inflammaging
characterized
by
increased
expression
AP-1
transcription
factor
chemokine
genes,
significantly
cellular
senescence.
Furthermore,
mesenchymal
display
remarkable
decrease
Collagen
Elastin
stemness.
decline
further
exacerbated
program
macrophages
communications
between
lungs.
These
findings
highlight
dysregulations
observed
both
their
supportive
cells,
potentially
contributing
susceptibility
populations
Molecular Metabolism,
Journal Year:
2024,
Volume and Issue:
84, P. 101954 - 101954
Published: May 6, 2024
The
human
adrenal
cortex
comprises
three
functionally
and
structurally
distinct
layers
that
produce
layer-specific
steroid
hormones.
With
aging,
the
undergoes
functional
structural
alteration
or
"adrenal
aging",
leading
to
unbalanced
production
of
Given
marked
species
differences
in
biology,
underlying
mechanisms
aging
have
not
been
sufficiently
studied.
This
study
was
designed
elucidate
linking
alterations
cortex.
We
conducted
single-cell
RNA
sequencing
spatial
transcriptomics
analysis
aged
data
this
suggest
multiple
signaling
pathways
underlie
abnormal
layered
structure
changes
steroidogenic
cells.
also
highlighted
macrophages
mediate
age-related
adrenocortical
cell
inflammation
senescence.
is
first
detailed
at
resolution
helps
mechanism
thereby
a
better
understanding
pathophysiology
disorders
associated
with
aging.
Scientific Data,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: June 26, 2024
Abstract
Major
depressive
disorder
(MDD)
and
substance-use
disorders
(SUDs)
often
lead
to
premature
aging,
increasing
vulnerability
cognitive
decline
other
forms
of
dementia.
This
study
utilized
advanced
systems
bioinformatics
identify
aging
“signatures”
in
MDD
SUDs
evaluated
the
potential
for
known
lifespan-extending
drugs
target
reverse
these
signatures.
The
results
suggest
that
inhibiting
transcriptional
activation
FOS
gene
family
members
holds
promise
mitigating
SUDs.
Conversely,
antidepressant
activating
PI3K/Akt/mTOR
pathway,
a
common
mechanism
rapid-acting
antidepressants,
may
accelerate
patients,
making
them
unsuitable
those
with
comorbid
aging-related
conditions
like
dementia
Alzheimer’s
disease.
Additionally,
this
innovative
approach
identifies
anti-aging
interventions
such
as
Deferoxamine,
Resveratrol,
Estradiol
valerate,
natural
compounds
zinc
acetate,
genistein,
ascorbic
acid,
regardless
anxiety
disorders.
These
findings
illuminate
effects
offer
insights
into
treatment
strategies
patients
conditions,
including
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117225 - 117225
Published: July 30, 2024
The
Activator
Protein
1
(AP-1)
transcription
factor
complex
plays
a
pivotal
role
in
the
regulation
of
cancer-related
genes,
influencing
cancer
cell
proliferation,
invasion,
migration,
angiogenesis,
and
apoptosis.
Composed
multiple
subunits,
AP-1
has
diverse
roles
across
different
types
environmental
contexts,
but
its
specific
mechanisms
remain
unclear.
advent
multi-omics
approaches
shed
light
on
more
comprehensive
understanding
AP-1's
mechanism
gene
regulation.
This
review
collates
recent
genome-wide
data
provides
an
overview
expression,
structure,
function,
interaction
diseases.
An
examination
these
findings
can
illuminate
intricate
nature
significant
involvement
progression
Moreover,
we
discuss
potential
use
as
target
for
individual
therapy
explore
various
challenges
associated
with
such
approach.
Ultimately,
this
valuable
insights
into
biology
therapeutic
disease
treatments.
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
150, P. 114226 - 114226
Published: Feb. 14, 2025
Ovarian
cancer
(OC)
is
a
deadly
gynecologic
associated
with
metastasis,
recurrence,
and
treatment
resistance.
The
expression
of
the
alanine-serine-cysteine
transporter
2
(ASCT2)
has
been
linked
to
poor
prognosis
immune
cell
infiltration
in
OC
tumors,
but
underlying
mechanisms
are
unclear.
Lentiviral
constructs
were
used
manipulate
ASCT2
cells
(SKOV-3).
effects
on
SKOV-3
behaviors
including
proliferation,
invasion,
migration,
apoptosis,
cycle
assessed
using
various
assays.
correlation
between
was
analyzed
Cancer
Genome
Atlas
(TCGA)
database.
Co-culture
experiments
conducted
evaluate
impact
overexpression
NK
cells,
followed
by
transcriptomics
cytokine
analysis.
levels
characterized
qPCR
western
blotting.
significantly
promoted
percentage
G1-phase
while
inhibiting
apoptosis.
silencing
had
opposite
effect.
negatively
OC.
led
excessive
IL-17A/F
production
inhibited
antitumor
activity
possibly
through
activating
IL-17
signaling
pathway.
core
regulatory
genes
c-JUN/PTGS2
this
pathway
upregulated,
cytokines
decreased
co-cultured
resulting
within
tumor.
Our
results
suggest
that
may
play
predominant
role
