The relationship between comorbidities, physical inactivity, kinesiophobia and physical performance in hypertensive individuals: a cross-sectional study

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 11, 2025

Language: Английский

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Healthy aging: Linking causal mechanisms with holistic outcomes

Aging Cell, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 18, 2023

Identifying and understanding the impact of differing exposures over lifecourse necessitates contextualizing different levels influence ranging from genetics, epigenetics, geography, psychosocial networks. Over last 50 years, there has been remarkable progress in our cellular molecular mechanisms that biological aging, with promise improving not only lifespan but also healthspan. However, because healthspan is affected by diverse environmental (both psychosocial) genetic heterogeneity, applying this at a personalized level remains challenging. beneficial detrimental) hierarchical geography to society personal networks across wide range domains, including ecological (e.g., air pollution clean water), structural disparities stress response) lifestyle diet, exercise, biobehavioral patterns). Approaching aging as contextual regulation inter-connectedness within whole-body framework (i.e., holistic) may provide path toward personalizing geroscience. Further point, editorial Ferrucci et al. (2023) special issue calls for collaboration between gerontologists geriatricians, better assess health trajectories promote healthy aging. This thematic was motivated idea value framing holistic outcome requiring approaches invited manuscripts along three interconnected themes: (1) pathways, (2) approaches, (3) interventions targeting multiple organ systems mechanistic pathways. Central geroscience quest identify understand hallmarks) increase disease risk chronological As organisms age, damage accumulation entropy susceptibility morbidity, cancer, heart disease, neurodegenerative disorders, frailty. A prominent hallmark cells senescent phenotype. First described early 1960s, were initially considered natural defense against they prevent damaged proliferating. time, their now recognized contribute age-related tissue deterioration chronic diseases, highlighting paradoxical role both promoting impeding In review, Kuehnemann & Wiley discuss dual nature, contribution alongside essential homeostasis, underscores necessity targeted mitigate negative effects while preserving aspects improve outcomes. Nicotinamide adenine dinucleotide (NAD) critical coenzyme metabolism, playing key homeostasis. NAD decline contributing processes, notably mitochondrial function. Claudia Chini colleagues review metabolism context senescence (Chini al., (2023), potential replacement therapies interaction other hallmarks, suggesting comprehensive these interactions crucial advancing treatments consistent hypothesis. Centenarians hold fascination among popular press. discovering deciphering variants centenarians confer protection diseases longevity challenge. study Wang fewer somatic mutations observed when compared younger controls, revealing specific genomic regions conserved long-lived individuals, an enhanced DNA repair ability, factors potentially human longevity. The African killifish emerged valuable model organism; just few months, it uniquely suited studying processes diseases. Its genome sequenced, further allowing manipulation association studies. Ruparelia describe utility sarcopenia longevity, showing muscle function notable reversals "earlier-life" phenotypes older age. study, triglyceride depletion used lipid nutrient homeostasis through SIRT1 calorie restriction. Understanding crosstalk vital developing integrative enhance extend lifespan. Moaddel conducted cross-sectional analysis individuals aged 22–92 years old assessment biomarkers biofluids tissues same age-associated metabolic pathways facilitate discovery underlying phenotypic significance cardiorespiratory fitness (CRF) increasingly past decades. CRF refers ability cardiovascular respiratory supply oxygen skeletal muscles respiration bioenergetics during sustained physical activity. link methylation clocks emerging area research, bridging measure rate or pace Kawamura associations lifestyle-related cohort men, finding higher correlated delayed though smoking) had more significant impact, nuanced interplay fitness, behavioral exposures, perspective Langevin define integrated, process based on biology, behavior, social/physical environment. From vantage point National Center Complimentary Integrative Health (NCCIH), commentary describes challenges multicomponent advocate balanced exploration pharmacologic nonpharmacologic strategies. Development outcomes gauge pathogenetic end-organ necessary investigate prevention intervention strategies level. Jiang adults without hypertension wherein examine complexity beat-to-beat blood pressure fluctuations vascular alterations due Lower greater arterial stiffness worse endothelial Additional multimodal counteract physiological multisystem dysregulation movement-based mind–body reviewed Loewenthal examples Tai Chi yoga preventative treat frailty adults. Ma provided discussion approach comparing long-term short-term practice Acosta innovative integrating humanism into patient care address metaphysical needs. Notably, out spirituality would have mechanistically driven exemplified bereavement Palitsky demonstrates how religious existential variables related risk. efficacious are broadly acceptable, cost-effective, scalable coin realm geroscientists. issue, Li suggest strategy designing aimed Instead associated phenotypes, effecting hallmarks should be dysfunction), positing could cascading process. 100 ago, metformin become most widely prescribed oral medication diabetes mellitus experiencing rediscovery sorts indications tuberculosis, weight loss, COVID-19, Corley examined epigenetics immune monocytes CD8+ T virally suppressed HIV infection. identified cell-type-specific myeloid effects, evidenced decreased epigenetic age monocytes, change cells. Given geroprotective treatment Bannister 2014; Keys 2022), large clinical trials using populations encouraged interpret heterogeneity. Although canakinumab, monoclonal antibody inhibiting IL-1β, reduces major adverse events, non-small cell lung inflammatory anemia, gout, joint osteoarthritis, canakinumab unclear. than 10,000 participants enrolled CANTOS trial described. previous myocardial infarction, frailty, measured 34-item cumulative deficit index, reduced, despite reductions biomarker C-reactive protein (Orkaby 2023). results highlight elusive nature phenotype approached system-based manner, need framework. There several products senomorphic properties polyphenols flavonoids. Here, Liu screened medicinal agent library rutin, phytochemical potent activity senescence-associated secretory (SASP), well efficacy chemotherapeutic treatments. Finally, highlighted benefits target exercise. Two studies report exercising muscle. Voisin extensive meta-analysis 3176 specimens longitudinal cohorts (aerobic, resistance, high-intensity interval training) those disuse. revealed baseline aerobic transcriptomic profiles, disuse resulted transcriptome. second Jankowski acceleration markers HIV, before after 24-week exercise program. third Manning performance battery sedentary Italian (Act Ageing) U.S. Veterans participating program (Gerofit). These collectively evidence training viable decelerate reverse particularly functional capacity humans. dramatically improved 70 nevertheless increased exacerbated lifestyles, psychological stress, processed foods, weakened social Furthermore, low- middle-income fortunate realize all especially such obesity (Safiri 2022). Additionally, polypharmacy having multi-morbidity cost independently mortality (Justice 2018). modern world complex cognitive decline, isolation, fragmentation left many feeling abandoned digital we chose emphasize multidimensional transdisciplinary research importance links experiences markers, delving advocating pivotal Inspired Patrick Pietroni's definition being (Pietroni, 1997), emphasizes transcends mere absence integrated addresses cognitive, behavioral, motor, sensory, autonomic, cellular, molecular, affective domains optimize lived experience. Several goalposts issue. First, composite capture global organ-specific developed, engaging next-generation analytical methodologies incorporate assessments, multi-morbidity, capturing positive exposure entire strike balance population-based public medical providing access precision medicine regardless income geography. Second, encourages implementation proof-of-concept will require disciplines scientific perspectives challenge existing funding structures, urging updates accommodate interdisciplinary goal prioritizing field undervalue features dignity, beauty, subjective appreciation life. We must respectful, supportive, caring environment where heard, wisdom valued, presence cherished. MM conceived topic. MM, VCM, KAO wrote, revised, approved final manuscript. VCM served guest editors assisted recruiting authors. authors acknowledge thank contributors Aging Cell staff. received investigator-initiated grants (to institution) consultation fees Eli Lilly, Bayer, Gilead Sciences, Merck, ViiV. support NIH/NIDDK (R01DK125187) Emory AIDS Research (P30AI050409) work acknowledges Boston Claude D. Pepper OAIC (P30AG031679). No conflicts declare. Data sharing applicable article no new data created analyzed study.

Language: Английский

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Health and fitness marketing appeals to older consumers

Service Industries Journal, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: May 23, 2024

Language: Английский

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It Is Not Just a Matter of Motivation: The Role of Self-Control in Promoting Physical Activity in Older Adults—A Bayesian Mediation Model

Healthcare, Journal Year: 2024, Volume and Issue: 12(16), P. 1663 - 1663

Published: Aug. 20, 2024

This study aimed to understand how psychological factors affect regular exercise in older adults, hypothesising that trait self-control mediates the relationship between motivation types (intrinsic, extrinsic, and amotivation) time. In this cross-sectional study, 430 adults (mean age = 68.8 ± 6.72) completed questionnaires regarding their perceived self-control, towards leisure activities, level of physical activity. A Bayesian mediation analysis was performed, controlling for demographics. We documented positive direct (c' 0.021, 95%CI [0.001, 0.043]) indirect (ab 0.028, [0.014, effects intrinsic on exercise, a fully mediated effect extrinsic 0.027, [0.011, 0.046]), negative -0.281, [-0.368, -0.194]) -0.161, [-0.221, -0.105]) amotivation exercise. There no association 0.013, 95% CI [-0.013, 0.037]). conclusion, influence behaviour adults. Intrinsically motivated individuals resist sedentary living show higher while extrinsically ones rely are more susceptible non-adherence during mental fatigue. High is linked less reduced suggesting potential non-compliance with structured interventions.

Language: Английский

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INVESTIGATING THE INFLUENCE OF GENETIC PREDISPOSITIONS ON CARDIOVASCULAR DISEASE RISK AND EXPLORING POTENTIAL GENE-BASED THERAPEUTIC INTERVENTIONS

Published: Feb. 29, 2024

Introduction: Cardiovascular diseases (CVD) are a significant public health concern worldwide, necessitating effective prevention and management strategies. Lifestyle interventions play crucial role in mitigating CVD risk factors, yet their efficacy feasibility warrant further investigation. Objective: This study aims to evaluate the effectiveness of lifestyle interventions, including diet modification, exercise regimens, stress techniques, both managing preventing cardiovascular diseases. Methods: A comprehensive review existing literature was conducted examine impact on management. Relevant studies were identified through electronic databases, data extraction synthesis performed assess various interventions. Results: The highlighted importance reducing factors improving overall health. Effective strategies included dietary modifications, regular exercise, which demonstrated benefits Conclusion: encompassing vital components disease Further research is needed optimize implementation scalability these for broader impact.

Language: Английский

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Association between Weather and Self-Monitored Steps in Individuals with Prediabetes and Type 2 Diabetes in Sweden over Two Years

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(4), P. 379 - 379

Published: March 22, 2024

Background: Many studies have identified key factors affecting the rates of engagement in physical activity older adults with chronic disease. Environmental conditions, such as weather variations, can present challenges for individuals diseases, type 2 diabetes when engaging activity. However, few investigated influence on daily steps people especially those prediabetes and diabetes. Objective: This study association between variations self-monitored step counts over two years among Sweden. Methods: The is a secondary analysis using data from Sophia Step Study, aimed at promoting diabetes, which recruited participants urban primary care centers Stockholm one rural center southern Sweden eight rounds. measured counters (Yamax Digiwalker SW200) collected self-reported steps. average temperature, precipitation, hours sunshine were obtained Swedish Meteorological Hydrological Institute. A robust linear mixed-effects model was applied method. Results: There no found number taken basis. indicated that only 10% variation could be explained by after controlling age, gender, BMI. Conversely, individual approximately 38% observations. Conclusion: revealed there conditions reported taking part intervention years. Despite women younger more than their male counterparts.

Language: Английский

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Valores de referencia para la prueba de 5000 metros en atletas chilenos de 35 a 74 años: Estudio trans-versal (Reference values for the 5000-meter test in Chilean athletes aged 35 to 74 years: Cross-sectional study)

Retos, Journal Year: 2024, Volume and Issue: 54, P. 771 - 776

Published: March 13, 2024

Introducción: El atletismo es un deporte que busca superar el rendimiento atlético de los adversarios en conjunto disciplinas. Objetivo: Desarrollar una escala cualitativa para la valoración del 5000 metros planos atletas chilenos entre 35 a 74 años. Material y métodos: Estudio descriptivo transversal, cuya muestra considero 449 máster género femenino 903 masculino participaron prueba durante periodo 2014 2022, siendo estos datos obtenidos partir registro Federación Atletismo Máster Chile. fue determinado través tiempo utilizado completar prueba, mientras se construyó con percentiles < 10, ≥ 25, 50, 75 correspondiendo criterios excelente, muy bueno, regular pobre. Resultados: En carrera metros. La media 21:04:34 25:36:46 respectivamente. general, error estándar = 00:05:81 00:11:70 femenino, reportándose diferencias significativas tamaño efecto grande (p <0 ,001; d > 0,8) todas las categorías edad función sexo. Conclusión: creación permite evaluar clasificar nivel deportivo Palabras clave: Carrera; Atletismo; Rendimiento Atlético; Adulto. Abstract. Background: Athletics is sport that seeks to surpass the athletic performance of opponents in set disciplines. Objective: Develop qualitative scale for assessment 5000-meter dash Chilean athletes between and years old. methods: Cross-sectional descriptive study, whose sample considers female male master who participated test during period these data being obtained from registry Federation Master Athletic was determined through time used complete test, while constructed with 75, corresponding criteria excellent, very good, average poor. Results: In race test. The males females respectively. standard mean gender female-female gender, reporting significant differences large effect size 0,001; 0. 8) all age categories based on sex. Conclusion: creation allows evaluating classifying sporting level years. Keywords: Running; Track field; Performance; Adult.

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Outpatient Care Models: The Gerofit Model of Care for Exercise Promotion in Older Adults

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 205 - 213

Published: Jan. 1, 2024

Language: Английский

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Physical Performance, Body Composition, and Oral Health in Community-Residing Older Adults: A Cross-Sectional Study

Geriatrics, Journal Year: 2024, Volume and Issue: 9(4), P. 89 - 89

Published: June 26, 2024

Physical activity is essential for healthy aging. This study aimed to identify an association between physical performance, body fat percentage (%BF), and the perception of oral health-related quality life (OHRQoL) in independent older adults.

Language: Английский

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Tai Chi Practice Buffers Aging Effects in Functional Brain Connectivity

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 901 - 901

Published: Sept. 6, 2024

Tai Chi (TC) practice has been shown to improve both cognitive and physical function in older adults. However, the neural mechanisms underlying benefits of TC remain unclear. Our primary aims are explore whether distinct age-related TC-practice-related relationships can be identified with respect either temporal or spatial (within/between-network connectivity) differences. This cross-sectional study examined recurrent network dynamics, employing an adaptive, data-driven thresholding approach source-localized resting-state EEG data order identify meaningful connections across time-varying graphs, using features derived from a hidden Markov model (HMM). Mann-Whitney U tests assessed between-group differences by age healthy younger adult controls (YACs,

Language: Английский

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