Human Physiology, Journal Year: 2024, Volume and Issue: 50(4), P. 374 - 382
Published: Aug. 1, 2024
Language: Английский
Aging Cell, Journal Year: 2024, Volume and Issue: 23(4)
Published: Feb. 21, 2024
Evaluation of the influence primary and secondary aging on manifestation molecular cellular hallmarks is a challenging currently unresolved issue. Our study represents first demonstration distinct role chronic inflammation/physical inactivity - most important drivers aging, in regulation transcriptomic proteomic profiles human skeletal muscle. To achieve this purpose, young healthy people (n = 15), 8) older 37) patients with knee/hip osteoarthritis, model to effect long-term inflammation vastus lateralis muscle, were included study. It was revealed that widespread substantial age-related changes gene expression relative (~4000 genes regulating mitochondrial function, proteostasis, cell membrane, secretory immune response) related physical rather than aging. Primary contributed mainly (~200) encoding nuclear proteins (regulators DNA repair, RNA processing, transcription), (genes respiratory enzymes, complex assembly factors, regulators cristae formation reactive oxygen species production), as well proteostasis. found associated regulated at post-transcriptional level. The set putative their potential transcriptional can be used resource for further targeted studies investigating individual transcription factors emergence senescent phenotype.
Language: Английский
Citations
9
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2025, Volume and Issue: unknown, P. 195086 - 195086
Published: Feb. 1, 2025
Language: Английский
Citations
0
Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 133, P. 105807 - 105807
Published: March 1, 2025
Language: Английский
Citations
0
European Journal of Applied Physiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Language: Английский
Citations
0
Healthcare, Journal Year: 2025, Volume and Issue: 13(7), P. 834 - 834
Published: April 6, 2025
Aging has been thought to be factual, inherited, and obligatory. However, aging can divided into primary (i.e., inevitable physiological changes) secondary age-associated changes driven by life choices, environment, society) aging. The impact of social norms choices is why no two 70-year-olds look the same. choice that appears have strongest on physical activity. Research continues highlight power mitigating age-related losses via activity debunking notion such as falls, frailty, functional decline are inevitable. Physiotherapists healthcare professionals who reverse or slow down prevent from occurring. health profession's experts in movement science, whose interventions primarily center around medicine. Thus, physiotherapists function pharmacists well-positioned prescribe dosages needed for wellness promotion well disease prevention management. This paper provides guidance perspective physiotherapist exercise prescription most optimal consumable an older population.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: July 2, 2024
Keywords: inflammation, chronic disease, cardiovascular, cancer, CRP, cardiometabolic, social determinants of health, clonal hematopoiesis
Language: Английский
Citations
1
Aging Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
Abstract Ageing substantially impairs skeletal muscle metabolic and physical function. Skeletal mitochondrial health is also impaired with ageing, but the role of fragmentation in age‐related functional decline remains imprecisely characterized. Here, using a cross‐sectional study design, we performed detailed comparison characteristics relation to vivo markers exercise capacity between young middle‐aged individuals. Despite similar overall oxidative phosphorylation (young: 99 ± 17 vs. middle‐aged: 27 pmol O 2 .s −1 .mg , p = 0.95) intermyofibrillar density 5.86 0.57 5.68 1.48%, 0.25), older participants displayed more fragmented network 1.15 0.17 1.55 0.15 A.U., < 0.0001), lower cristae 23.40 7.12 13.55 4.10%, 0.002) reduced subsarcolemmal 22.39 6.50 13.92 4.95%, 0.005). Linear regression analysis showed that 87% variance associated maximal oxygen uptake could be explained by alone, whereas was positively for extraction during exercise. Intramuscular lipid accumulation negatively density. Collectively, our work highlights critical mitochondria age‐associated declines
Language: Английский
Citations
1
Физиология человека, Journal Year: 2024, Volume and Issue: 50(4), P. 68 - 79
Published: Oct. 31, 2024
Physical inactivity and aging cause significant impairments in the functionality mechanical properties of skeletal muscles, as well remodeling extracellular matrix (ECM). We aimed to study effect long-term age on biogenesis ECM muscle. For quantitative mass spectrometry-based proteomic analysis RNA sequencing, biopsy samples were taken from m. vastus lateralis 15 young healthy volunteers, 8 37 elderly patients with primary osteoarthritis knee/hip joint – which is a model for studying effects muscles. detected 1022 mRNAs 101 associated proteins (matrisome). An increase expression two dozen highly abundant matrisome proteins, specific (in relation people), was detected; however, changes mRNA encoding regulators (enzymatic secreted proteins) similar. Comparison previous transcriptomic data showed that we described differed markedly caused by aerobic physical training people, particular, dominant and, especially, enzymatic proteins. profiles these regulatory genes may be useful identifying pharmacological targets prevention adverse changes/activation under various pathological conditions/physical training.
Language: Английский
Citations
0
Human Physiology, Journal Year: 2024, Volume and Issue: 50(4), P. 374 - 382
Published: Aug. 1, 2024
Language: Английский
Citations
0