An exploratory study of pro-inflammatory cytokines in individuals with alcohol use disorder: MCP-1 and IL-8 associated with alcohol consumption, sleep quality, anxiety, depression, and liver biomarkers DOI Creative Commons
Narjis Kazmi, Gwenyth R. Wallen, Li Yang

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 11, 2022

High levels of sleep disturbances reported among individuals with alcohol use disorder (AUD) can stimulate inflammatory gene expression, and in turn, may alter pro-inflammatory cytokines levels. We aimed to investigate associations between cytokine markers subjective measures quality, psychological variables consumption AUD.This exploratory study is comprised AUD (n = 50) healthy volunteers 14). Spearman correlation was used correlations plasma clinical interest (liver markers, patient anxiety/depression scores, presence mood and/or anxiety disorders (DSM IV/5); history variables.The group significantly older, poorer higher average drinks per day as compared controls. Within the group, IL-8 MCP-1 had positive significant sleep, anxiety, depression drinking variables. Specifically, were associated (p 0.004), scores 0.006) < 0.001), number days 0.002), heavy 0.001) total 0.001). The multiple linear regression model for showed that after controlling status days, older participants 0.003) more 0.016), alkaline phosphatase level level.This analysis revealed consumption, group. Furthermore, liver highly correlated certain suggesting a possible relationship chronic inflammation. These contribute prolonged responses potentially risk co-morbid diseases.

Language: Английский

Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China DOI Creative Commons
Jianyu Que, Le Shi, Jiahui Deng

et al.

General Psychiatry, Journal Year: 2020, Volume and Issue: 33(3), P. e100259 - e100259

Published: June 1, 2020

Background Healthcare workers fighting against the coronavirus disease 2019 (COVID-19) pandemic are under tremendous pressure, which puts them at an increased risk of developing psychological problems. Aims This study aimed to investigate prevalence problems in different healthcare (ie, physicians, medical residents, nurses, technicians and public health professionals) during COVID-19 China explore factors that associated with onset this population crisis. Methods A cross-sectional, web-based survey was conducted February 2020 among pandemic. Psychological were assessed using Generalized Anxiety Disorder Scale, Patient Health Questionnaire Insomnia Severity Index. Logistic regression analyses used Results The symptoms anxiety, depression, insomnia overall 46.04%, 44.37%, 28.75% 56.59%, respectively. professionals 60.35%, 50.82%, 62.02%, 57.54% 62.40%, Compared who did not participate front-line work, had a higher In addition, attention negative or neutral information about pandemic, receiving feedback from families friends joined unwillingness join work if given free choice three major for these Conclusions pervasive Receiving participating appear be important should protected timely interventions proper feedback.

Language: Английский

Citations

548

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework DOI Open Access
George F. Koob,

Ian M. Colrain

Neuropsychopharmacology, Journal Year: 2019, Volume and Issue: 45(1), P. 141 - 165

Published: June 24, 2019

Language: Английский

Citations

204

Alcohol and sleep-related problems DOI
Sean He, Brant P. Hasler, Subhajit Chakravorty

et al.

Current Opinion in Psychology, Journal Year: 2019, Volume and Issue: 30, P. 117 - 122

Published: April 19, 2019

Language: Английский

Citations

77

The association between alcohol consumption and sleep disorders among older people in the general population DOI Creative Commons
Annie Britton, Linda Ng Fat, Aidan Neligan

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: March 24, 2020

Abstract The relationship between alcohol consumption and sleep disturbance is complex. association of dependence with insomnia likely to be bidirectional in nature. Alcohol use common among older people many societies the prevalence tends increase age, therefore this group warrants particular consideration. We explored cross sectional long term (30 years) associations drinking (volume hazardous drinking) duration a general population study adults (6,117 male female civil servants followed for 30 years). For men, more than 21 units (approximately 168 grams) per week, compared not drinking, was associated waking several times night (odds ratio 1.30, confidence intervals 1.02–1.66). Men who maintained heavy volume over three decades observation, or had an unstable pattern, tended have worse profiles terms tired times. Sustained (as measured by AUDIT-C scale) also profiles. Findings women were so clear. In based setting, high volumes may contribute problems particularly men. People age should discouraged from using as aid.

Language: Английский

Citations

73

Impact of sleep duration and sleep disturbances on the incidence of dementia and Alzheimer's disease: A 10-year follow-up study DOI Creative Commons
Ying Xiong,

Jonas Tvedt,

Torbjörn Åkerstedt

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 333, P. 115760 - 115760

Published: Jan. 28, 2024

The nature of the relationship between sleep problems and dementia remains unclear. This study investigated measures in older adults (≥ 65) using data from English Longitudinal Study Ageing (ELSA) further causal association Mendelian randomization (MR) analysis. In total 7,223 individuals, 5.7 % developed (1.7 Alzheimer's disease (AD)) within an average 8 (± 2.9) years. Cox regression models MR were employed. Long duration (>8 h) was associated with 64 increased risk incident 2-fold high AD compared to ideal (7-8 h). particularly evident older-older (≥70 years) those who consumed alcohol. Short (<7 lower among but higher younger-older adults. Sleep disturbances perceived quality not or AD. did reveal associations dementia. These findings suggest that self-reported short long frequent alcohol consumption are Early detection these patterns may help identify individuals at risk.

Language: Английский

Citations

9

Cognitive Behavioral Therapy for Insomnia across the Spectrum of Alcohol Use Disorder: A Systematic Review and Meta-Analysis DOI Creative Commons
Cagdas Türkmen, Carlotta L. Schneider, Wolfgang Viechtbauer

et al.

Sleep Medicine Reviews, Journal Year: 2025, Volume and Issue: 80, P. 102049 - 102049

Published: Jan. 11, 2025

Language: Английский

Citations

1

Pharmacological and Nonpharmacological Interventions to Address Sleep Disturbance in Substance use Disorders DOI
Majd Al‐Soleiti, Meghna P. Mansukhani, Bhanu Prakash Kolla

et al.

Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 29, 2025

Language: Английский

Citations

1

Association Between Alcohol Use Patterns and Insomnia Symptoms or Poor Sleep Quality Among Adult Women: An Internet Cross-Sectional Survey in Japan DOI Creative Commons

Suguru Nakajima,

Yuichiro Otsuka, Yoshitaka Kaneita

et al.

Clocks & Sleep, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Feb. 13, 2025

It is unclear whether patterns of alcohol consumption are associated with sleep disturbance. We aimed to investigate the relationship between comprehensive alcohol-related factors and insomnia symptoms, as well quality, among adult women in Japan. Responses an online cross-sectional survey were gathered from 12,000 women. The items included demographic characteristics, (Alcohol Use Disorders Identification Test, nightcaps, years drinking), sleep-related (sleep duration, quality), lifestyle-related factors, mental health. Binary logistic regression was used both symptoms quality. A total 10,233 final analysis. results revealed that several behaviors, including nightcaps drinking, significantly poor Specifically, all types a higher odds ratio than other items. Our findings suggest specific particularly quality Intervention programs for should be provided prevent problems

Language: Английский

Citations

1

Sleep health disparity: the putative role of race, ethnicity and socioeconomic status DOI Open Access

Shazia Jehan,

Alyson K. Myers, Ferdinand Zizi

et al.

Sleep Medicine and Disorders International Journal, Journal Year: 2018, Volume and Issue: 2(5)

Published: Dec. 31, 2018

Sleep plays a pivotal role in both physical and mental health. quality can be affected by many socio demographic factors, such as race and/or ethnicity, well economic status (SES). Chronic sleep deprivation is associated with unhealthy behaviors alcohol abuse also places individuals at risk for chronic diseases including obesity, cardiovasculardisease (CVD), depression, anxiety. This review explores the common factors SES that lead to disturbances. Among these are shift work, poor dietary habits, smoking abuse. Such need considered health care providers clinical assessment management plans of patients disorders.

Language: Английский

Citations

64

Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis DOI
Mary Beth Miller, Marissa L. Donahue, Kate B. Carey

et al.

Drug and Alcohol Dependence, Journal Year: 2017, Volume and Issue: 181, P. 200 - 207

Published: Oct. 23, 2017

Language: Английский

Citations

63