Multivariate analyses of polygenic risk for impulsivity and alcohol use: a study of longitudinal trajectories of binge drinking in emerging adulthood DOI Open Access
Alex P. Miller

Published: Aug. 1, 2022

[EMBARGOED UNTIL 8/1/2023] This dissertation aimed to extend previous genetic and neurobiological studies of the shared etiology impulsive personality traits (IPTs), alcohol consumption use disorder (AUD). The overarching goals were (1) leverage advanced multivariate genome-wide association study (GWAS) approaches improve current models neurogenetic liability for IPTs using a dual-systems framework (e.g., top-down lack self-control, bottom-up sensation seeking urgency), (2) apply improved polygenic scoring (PGS) techniques prediction changes in binge drinking developmentally relevant longitudinal samples. Study 1 included several structural, stratified, analyses epigenetic, transcriptomic, neuroimaging datasets. Analyses data used construct investigate converging discriminating evidence IPT factor architecture with AUD. GWAS summary statistics generated utilized 2 IPT, consumption, AUD PGS variables, which then specified as predictors progression three independent samples spanning adolescence early adulthood. Results from suggested distinct across tested traits, though also indicated robust neurobiologically defined basis between consumption. results highlighted important associations PGSs trajectories time In aggregate, these represent novel findings regarding constructs increase understanding their relevance phenotypes.

Language: Английский

Neurogenetic and multi‐omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder DOI Creative Commons
Alex P. Miller, Ian R. Gizer

Addiction Biology, Journal Year: 2024, Volume and Issue: 29(2)

Published: Jan. 29, 2024

Sensation seeking is bidirectionally associated with levels of alcohol consumption in both adult and adolescent samples, shared neurobiological genetic influences may part explain these associations. Links between sensation use disorder (AUD) primarily manifest via increased rather than through direct effects on increasing problems consequences. Here the overlap among seeking, consumption, AUD was examined using multivariate modelling approaches for genome-wide association study (GWAS) summary statistics conjunction neurobiologically informed analyses at multiple investigation. Meta-analytic genomic structural equation (GenomicSEM) were used to conduct GWAS AUD. Resulting downstream examine brain tissue enrichment heritability evidence (e.g., stratified GenomicSEM, RRHO, correlations neuroimaging phenotypes), identify regions likely contributing observed across traits H-MAGMA LAVA). Across approaches, results supported neurogenetic architecture characterised by overlapping genes expressed midbrain striatal tissues variants cortical surface area. Alcohol evidenced relation decreased frontocortical thickness. Finally, mediation models provided mediating associations This extends previous research examining critical sources multi-omic which underlie phenotypic

Language: Английский

Citations

10
Self‐reported sleep and circadian characteristics predict alcohol and cannabis use: A longitudinal analysis of the National Consortium on Alcohol and Neurodevelopment in Adolescence Study DOI
Brant P. Hasler, Jessica L. Graves, Meredith L. Wallace

et al.

Alcoholism Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 46(5), P. 848 - 860

Published: May 1, 2022

Abstract Background Growing evidence indicates that sleep characteristics predict future substance use and related problems. However, most prior studies assessed a limited range of characteristics, studied narrow age span, included few follow‐up assessments. Here, we used six annual assessments from the National Consortium on Alcohol Neurodevelopment in Adolescence (NCANDA) study, which spans adolescence young adulthood with an accelerated longitudinal design, to examine whether multiple any year alcohol cannabis following year. Methods The sample 831 NCANDA participants (423 females; baseline 12–21 years). Sleep variables circadian preference, quality, daytime sleepiness, timing midsleep (weekday/weekend), duration (weekday/weekend). Using generalized linear mixed models (logistic for cannabis; ordinal binge severity), tested each repeatedly measured characteristic (years 0–4) predicted (alcohol severity or use) 1–5), covarying age, sex, race, visit, parental education, previous year's use. Results Greater eveningness, more later weekend timing, shorter (weekday/weekend) all severe drinking Only greater eveningness likelihood Post‐hoc stratified exploratory analyses indicated some associations (e.g., duration) only female participants, middle/high school versus post‐high adolescents were vulnerable sleep‐related risk Conclusions Our findings support relevance sleep/circadian Preliminary suggest these factors vary based developmental stage sex. underscore need attention as potential youth may inform new avenues prevention intervention.

Language: Английский

Citations

24
Assessing cross-lagged associations between depression, anxiety, and binge drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study DOI Creative Commons
Connor McCabe, Ty Brumback, Sandra A. Brown

et al.

Drug and Alcohol Dependence, Journal Year: 2023, Volume and Issue: 243, P. 109761 - 109761

Published: Jan. 5, 2023

Language: Английский

Citations

11
Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder DOI Creative Commons
Alex P. Miller, Kellyn M. Spychala, Wendy S. Slutske

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Binge drinking is a relatively common pattern of alcohol use among youth with normative frequency trajectories peaking in emerging and early adulthood. Frequent binge critical risk factor for not only the development disorders (AUDs) but also increased odds alcohol-related injury death, thus constitutes significant public health concern. Changes across are strongly associated changes impulsive personality traits (IPTs) which have been hypothesized as intermediate phenotypes genetic heavy AUD. The current study sought to examine extent longitudinal intoxication adolescence adulthood influences underlying dual-systems IPTs (i.e., top-down [lack self-control] bottom-up [sensation seeking urgency] constructs) alongside consumption Associations were tested using conditional latent growth curve polygenic score (PGS) models three independent samples ( N =10,554). Results suggested consistent associations all between sensation PGSs model intercepts higher at first measurement occasion) slopes steeper increases toward peak frequency). Urgency significantly or frequency. Collectively, these findings highlight role unique correlated IPT alcohol-specific factors emergence escalation during

Language: Английский

Citations

1
Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder DOI Creative Commons
Alex P. Miller, Ian R. Gizer

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Sensation seeking is bidirectionally associated with levels of alcohol consumption in both adult and adolescent samples shared neurobiological genetic influences may part explain this association. Links between sensation use disorder (AUD) primarily manifest via increased rather than through direct effects on increasing problems consequences. Here the overlap seeking, consumption, AUD was examined using multivariate modeling approaches for genome-wide association study (GWAS) summary statistics conjunction neurobiologically-informed analyses at multiple investigation. Meta-analytic genomic structural equation (GenomicSEM) were used to conduct GWAS AUD. Resulting downstream examine brain tissue enrichment heritability evidence (e.g., stratified GenomicSEM, RRHO, correlations neuroimaging phenotypes) identify regions likely contributing observed across traits HMAGMA, LAVA). Across approaches, results supported neurogenetic architecture characterized by overlapping genes expressed midbrain striatal tissues variants cortical surface area. Alcohol evidenced relation decreased frontocortical thickness. Finally, mediation models provided mediating associations This extends previous research examining critical sources multi-omic among which underlie phenotypic associations.

Language: Английский

Citations

2
Risk factors for binge drinking in young adulthood: The roles of aggregate genetic liability and impulsivity-related processes DOI
Séverine Lannoy, Jon Heron, Matthew Hickman

et al.

Journal of Studies on Alcohol and Drugs, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 28, 2023

Objective: Binge drinking is characterized by excessive alcohol use and widespread in youth. We explore the relationship between binge drinking's risk factors considering (i) aggregate genetic liability (polygenic score [PGS]) for problems (ii) impulsivity-related processes. examined whether associations PGS were mediated impulsivity, with a possible shared phenotypes impulsivity. Method: included participants from Avon Longitudinal Study of Parents Children (N=2,545 participants) evaluated processes (sensation seeking at age 18 inhibition 24). measured frequency (24 years old) as outcome. Correlations structural equation models used to test hypothesized model relationships among these variables. Results: Higher was related higher both (standardized betas 0.055-0.064, all ps<0.009). also found an association sensation beta=0.224, p<0.0001), but not beta=-0.015, p=0.437). Though mainly direct, proportion (14.61%). Conclusions: Sensation end adolescence may constitute good target prevent adulthood, while role improve our understanding at-risk

Language: Английский

Citations

1
Uncontrolled eating and sensation-seeking partially explain the prediction of future binge drinking from adolescent brain structure DOI Creative Commons
Roshan Prakash Rane, Milena Philomena Maria Musial, Anne Marie Beck

et al.

NeuroImage Clinical, Journal Year: 2023, Volume and Issue: 40, P. 103520 - 103520

Published: Jan. 1, 2023

Binge drinking behavior in early adulthood can be predicted from brain structure during adolescence with an accuracy of above 70 %. We investigated whether this accurate prospective prediction alcohol misuse explained by psychometric variables such as personality traits or mental health comorbidities a data-driven approach. analyzed subset adolescents who did not have any prior binge experience at age 14 (IMAGEN dataset, n = 555, 47.38 % female). Participants underwent sMRI 14, assessments ages and 22, questionnaire 22. derived structural features T1-weighted magnetic resonance diffusion tensor imaging. Using Machine Learning (ML), we (age 22) 14) used counterbalancing oversampling to systematically control for 110+ wide range social, personality, other characteristics potentially associated drinking. evaluated if controlling variable resulted significant reduction ML accuracy. Sensation-seeking (-13.98±1.68%) assessed via the Substance Use Risk Profile Scale uncontrolled eating (-13.98±3.28%) Three-Factor-Eating-Questionnaire 22 led reductions upon them. Thus, sensation-seeking could partially explain future adolescent structure. Our findings suggest that share common neurobiological precursors discovered model. These seem 14. results facilitate detection increased risk inform clinical research trans-diagnostic prevention approaches misuse.

Language: Английский

Citations

1
Examining traumatic brain injury as a risk factor for violent offending: testing for cognitive and affective mediation DOI
Thomas Wojciechowski

Journal of Criminal Psychology, Journal Year: 2024, Volume and Issue: 14(4), P. 357 - 373

Published: April 8, 2024

Purpose While prior research has established that traumatic brain injury (TBI) is a risk factor for violent offending, there little understanding of mechanisms may underpin this relationship. This problematic, as better these could facilitate more effective targeting treatment. study aims to address gaps in the extant literature by examining TBI predictor offending and test mediation effects through cognitive constructs dual systems imbalance hostility among sample justice-involved youth (JIY). Design/methodology/approach The Pathways Desistance data were analyzed. first three waves set comprising responses 1,354 JIY Generalized structural equation modeling was used direct indirect interest. A bootstrap resampling process compute unbiased standard errors determining statistical significance effects. Findings Lifetime experience associated with increased frequency at follow-up. Hostility significantly mediated relationship, but did not. indicated programming focused on reducing who have experienced aid recidivism rates. Originality/value To best author’s knowledge, identify significant relationship between hostility.

Language: Английский

Citations

0
Brain-derived neurotrophic factor Val66Met polymorphism moderates the relationship between impulsivity, negative emotions, and binge drinking intensity in university students DOI
Farid Benzerouk, Fabien Gierski, Séverine Lannoy

et al.

Alcohol and Alcoholism, Journal Year: 2023, Volume and Issue: 58(5), P. 505 - 511

Published: June 17, 2023

Studies on the genetic factors involved in binge drinking (BD) and its associated traits are very rare. The aim of this cross-sectional study was to investigate differences association between impulsivity, emotion regulation BD a sample young adults according rs6265/Val66Met variant brain-derived neurotrophic factor (BDNF) gene, well-known candidate gene alcohol use disorders. We recruited 226 university students (112 women), aged 18 25 years old, from two centers France. participants completed measures related consumption, depression severity, state anxiety levels, impulsivity (UPPS-P), difficulties [Difficulty Emotion Regulation Scale (DERS)]. relationship score clinical characteristics BDNF genotype groups assessed by partial correlation analyses moderation analyses. showed that, Val/Val group, positively UPPS-P Lack Premeditation Sensation Seeking scores. In Met carriers Positive Urgency, lack Premeditation, Perseverance scores Clarity DERS. Moreover, with severity revealed that Val/Met moderated several variables BD. results present support hypothesis common specific vulnerability regarding rs6265 polymorphism.

Language: Английский

Citations

0
Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats DOI Creative Commons
Amy M. Gancarz, Devin P. Hagarty,

Moriah M. Cobb

et al.

Psychopharmacology, Journal Year: 2023, Volume and Issue: 240(10), P. 2201 - 2215

Published: Aug. 8, 2023

An important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose individuals toward uncontrolled drug use and relapse. A personality trait linked sensation seeking, i.e., preference for novel sensations/experiences. In an animal model operant novelty seeking predicts the acquisition self-administration.The primary goal this was evaluate hypothesis sensitivity reinforcing effects sensory stimuli more intensive aspects drug-taking behaviors, such as relapse.Rats were first tested Operant Novelty Seeking, during which responses resulted in complex visual/auditory stimuli. Next, rats trained respond water/cocaine reinforcers signaled by cue light. Finally, exposed extinction absence discrete cues subsequently single session cue-induced reinstatement, active previously paired delivery.The present study showed produce positively correlate responding self-administration but no association performance extinction. different pattern associations observed natural reward, case, water reinforcement. Here, degree also correlated reinforcement responding; however, did not testing reinstatement. Taken together, incongruence relationships indicates underlying difference between reinforcers.In summary, we found reinforcer-dependent relationship (i.e., seeking) responsivity signaling availability craving), demonstrating validity investigate

Language: Английский

Citations

0