The role of sex in the association between cannabis use disorder and resting-state functional connectivity

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Standard THC units: A tool to benchmark cannabis-related driving risks

International Journal of Drug Policy, Journal Year: 2025, Volume and Issue: 139, P. 104788 - 104788

Published: April 3, 2025

Language: Английский

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Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use

npj Mental Health Research, Journal Year: 2025, Volume and Issue: 4(1)

Published: April 24, 2025

Abstract Posttraumatic stress disorder (PTSD) is associated with poor hippocampal function and disrupted pattern recognition. Cannabis use highly prevalent in individuals PTSD, yet the impact on these cognitive functions poorly understood. Participants ( n = 111) a range of PTSD symptoms without regular cannabis completed mnemonic similarity task. We hypothesized that would be alterations separation ability symptoms. High were reduced performance minimal users. Regular users high showed greater separation, but low These results suggest may disrupt similar hippocampal-dependent processes, while it improve cross-sectional require longitudinal follow-up studies to evaluate causal effects PTSD.

Language: Английский

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Challenges and Insights of Cannabis Vaping Among Sexual Minority Individuals: Commentary on Maglalang et al. (2024)

Substance Use & Misuse, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: April 27, 2025

This commentary focuses on assessment challenges of cannabis vaping and the need to expand Minority Stress Theory (MST) understand elevated levels among sexual minority individuals. These topics are discussed as a Maglalang et. al (2024), who examined two novel measurements (i.e. recency number puffs). Our provides an overview relevant literature future directions for research Elevated rates individuals concerning given THC potency greater frequency product use, associated health concerns, individuals' access care. The existing body has focused heavily MST explain substance use fails consider several contextual factors (e.g. location companions) situational motives (situation or environment-dependent), creating narrow lens vapes, well other substances. underscores growing individuals, reported by et al. various accompanied in attempts quantify vape quantity. In addition, authors suggest expanding beyond explore more diverse set influencing

Language: Английский

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Cannabis Use Patterns in First Episode Psychosis and Schizophrenia: A Scoping Review and Case Series

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Background Cannabis use is associated with psychosis development and symptom relapse in persons schizophrenia spectrum disorders (SCZ). As more U.S. states legalize cannabis products increase potency, it crucial to better understand recent patterns SCZ. Methods We conducted a scoping review of research on SCZ after January 2016 present case series six inpatients from 2023–2024. Results Scoping review: Of 672 references, nine studies (775 participants) were included; none designed characterize quantity, frequency, or type over time. measurement methodology varied widely most did not follow recommendations for measuring use. Frequency quantity at study baseline reported by these ranged widely. At least minority participants each used very frequently; 0.6±0.6 3.4±2.2 joints/day. One small detailed product among users THC (93% flower, 80% edibles, 60% concentrates) CBD (40% 20% concentrates, 13% oils). Case Series Participants (32.0±14.4 years; 83.3% diagnosed SCZ) who 2.7±2.1 days/week. All leaf (3.1±2.3 joints/day); half (all heavy users) also concentrates (33.3%) edibles (16.7%). Conclusion Only measured SCZ; methodologies varied. legalization expands potency increases, further should its consequences

Language: Английский

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Riskanter Cannabiskonsum: Vorschlag einer Arbeitsdefinition

Suchttherapie, Journal Year: 2025, Volume and Issue: 26(02), P. 77 - 84

Published: May 1, 2025

Zusammenfassung Cannabiskonsum ist ein Risikofaktor für somatische und psychische Erkrankungen sowie (Verkehrs-)Unfälle. Das Fehlen einer einheitlichen Definition riskanten Cannabiskonsums erschwert derzeit die Kommunikation von Gesundheitsrisiken damit eine effektive Cannabisprävention Früherkennung in klinischer Praxis. Zudem mindert sie Vergleichbarkeit Studienergebnissen. Es bestehen der Literatur unterschiedliche Ansätze zu definieren, z. B. mittels Konsumfrequenz oder durch standardisierte Screeninginstrumente (z. CAST SDS). Anhand vier Kriterien (einfach, verhaltensbasiert, kontinuierlich evidenzbasiert) diskutieren wir Passung unterschiedlicher riskantem Cannabiskonsum. Auf dieser Grundlage haben einen Vorschlag dreiteilige Arbeitsdefinition erarbeitet: 1. gibt keinen risikofreien Konsum; 2. wird empfohlen, dass Cannabis grundsätzlich verschiedenen Personengruppen bzw. bestimmten Situationen vermieden werden sollte; 3. Konsumierende steigern ihre drei Verhaltensweisen: höhere Konsumfrequenz, THC-Konsummenge an Konsumtagen, Rauchen statt Verdampfen, insb. zusammen mit Tabak. Zukünftig könnten Risikozonen niedriges vs. moderates hohes Risiko) Schwellenwerte auf Basis empirischer Arbeiten bestimmt werden.

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Typical Hits, Grams, or Joints: Evaluating Cannabis Survey Measurement Strategies for Quantifying Consumption

Cannabis and Cannabinoid Research, Journal Year: 2022, Volume and Issue: 9(2), P. 646 - 658

Published: Dec. 28, 2022

Standardized survey measures that capture diverse cannabis consumption patterns are needed to inform public health and policy. Our team is developing a flexible, personalized, low-burden item inventory measure use estimate milligrams of THC (mgTHC) in large samples. This study aimed identify measurement gaps analysis implications associated with an initial pool candidate items assessed flower concentrate products (smoked and/or vaporized).

Language: Английский

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Brain reward function in people who use cannabis: a systematic review

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Feb. 6, 2024

Rationale Cannabis is one of the most widely used psychoactive substances globally. use can be associated with alterations reward processing, including affective flattening, apathy, anhedonia, and lower sensitivity to natural rewards in conjunction higher cannabis-related rewards. Such have been posited driven by changes underlying brain pathways, as per prominent neuroscientific theories addiction. Functional neuroimaging (fMRI) studies examined function cannabis users via monetary incentive delay (MID) fMRI task; however, this evidence yet systematically synthesised. Objectives We aimed integrate on MID relation metrics exposure (e.g., dosage, frequency) other behavioural variables. Method pre-registered review PROSPERO reported it using PRISMA guidelines. Literature searches were conducted PsycINFO, PubMed, Medline, CINAHL, Scopus. Results Nine included, comprising 534 people mean ages 16-to-28 years, which 255 who daily or almost daily, 279 controls. The literature date led largely non-significant group differences. A few differences ventral striatum while participants anticipated losses; caudate received neutral outcomes. correlations between withdrawal, age onset; inconsistent findings. Conclusions There emerging but altered task. Future are required confirm if system vulnerable experience a Use Disorder, postulated

Language: Английский

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Cannabis research in context: The case for measuring and embracing regional similarities and differences

Addiction, Journal Year: 2024, Volume and Issue: 119(9), P. 1502 - 1504

Published: March 7, 2024

Considerable differences in the types of cannabis products, methods use, social norms and cultures legal climates surrounding use exist among regions, resulting distinct contexts. Research examining accounting for these contextual is crucial to further understanding disorder, developing refining context sensitive strategies prevention, treatment harm reduction. The past two decades have seen increased legalization recreational across globe, prevalence emerging evidence cannabis-related harms [1]. We argue that precisely how impacts people who cannabis, as well likely why, may vary substantially depending upon variation legislation, promotion, acceptability around use. These factors create unique regionally specific 'cannabis contexts'. Although broader cross-cultural considerations apply all addictions we believe they are particularly important given global changes towards more lenient policies. aim increase awareness stimulate research debate regarding contexts shape processes underlying disorder (CUD) associated outcomes. percentage Δ9-tetrahydrocannabinol (THC) products has been increasing internationally [1], but there substantial markets type product Use higher-potency appears risen United States be common states legalized [2]. temporal regional health implications [3]. Further individual cannabinoid exposure, new THC rising popularity US market, with one six users reporting Δ8-THC [4]. produces fewer psychoactive effects than Δ9-THC, preferred those seeking medicinal benefit, indicating a potential difference attitudes Common routes administration (ROA) also differ throughout regions impact bioavailability cannabinoids. Cannabis combustion results faster onset action higher blood levels relative oral ingestion [5]. While smoking still most prevalent ROA Canada, edible [6] smoked flower combined tobacco European countries [7]. Nicotine cannabinoids compensatory synergistic neurobiological [8], nicotine–cannabis co-users severe CUD prognoses [9]. variations result differential frequent on other physical, cognitive mental policies, perceived it, influence trajectories probably contribute CUD. More permissive community heightened [10]. interplay policies feed into interact perceptions one's own producing different outcomes In States, availability declining parallel rates [11]. Despite such increases self-reported [12]. Some that, rather reflecting legitimate decline CUD, this seemingly contradictory pattern reflect reduced treatment-seeking some (e.g. [13]). tentatively agree: per se, concomitant drug then acquired, can alter drug's safety, turn potentially changing consequences [14]. Such forms messaging cannabis—for example, presence signs promoting benefits dispensaries California [15]. emergence evidence-based purported therapeutic appeal bring while already cannabis. contrast Canadian reported risk post-legalization [16], preliminary data from emergency psychiatric units indicate [17]. entry Europe [18]. short, local social, regulatory societal milieu which consumed exceedingly complex. There reasons affect initiates it affects them whether perceive effects. Greater attention improve our If experiences are—as suggest—potentially so variable, proceed investigating cannabis? One approach sample niche populations homogeneous, cannabis-only users, will ignore reality It complex picture need understand provide nuanced guidelines safer patterns generalize wider population Instead, researchers should embrace heterogeneity study context. To achieve this, recommend following; first, urge report standardized fashion. iCannToolkit [19] framework facilitating integration characterization context-specific proposes time-line follow-back (TLFB) methodology (in combination 5-mg unit ROA) an extensive self-report quantification method. Self-reports quick reliable proxy exposure [20]. Secondly, when testing time allows risks motives versus medicinal) relevant incorporate. When samples large enough, exploratory analyses assess Beyond studying valuable public regions—including often under-represented minority groups—over time. Finally, strongly studies incorporate explicit context' statements, including elements described Box 1. statements brief overview typical was conducted help characterize studies, improving synthesis. Over time, information contained even used meta-analytically explain findings regions. Location Year policy (i.e. status and/or commercial non-commercial) Description retail market (if applicable) method Average content available) Regional Janna Cousijn: Conceptualization (equal); funding acquisition supervision (lead); writing—original draft (supporting); writing—review editing (lead). Lauren Kuhns: (equal). Francesca Filbey: (supporting). Tom P. Freeman: Emese Kroon: This supported by grant 1R01 DA042490-01A1 awarded Cousijn Filbey National Institute Drug Abuse/National Health. All authors no conflicts interest declare.

Language: Английский

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Posttraumatic stress disorder, sleep and medical cannabis treatment: A daily diary study

Journal of Anxiety Disorders, Journal Year: 2022, Volume and Issue: 92, P. 102632 - 102632

Published: Sept. 16, 2022

Language: Английский

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